Zobrazeno 1 - 10
of 193
pro vyhledávání: '"John R Couchman"'
Publikováno v:
F1000Research, Vol 5 (2016)
A small group of cell surface receptors are proteoglycans, possessing a core protein with one or more covalently attached glycosaminoglycan chains. They are virtually ubiquitous and their chains are major sites at which protein ligands of many types
Externí odkaz:
https://doaj.org/article/5548e077d4844975a715079e08aeb8cb
Autor:
Antonios D Konitsiotis, Shu-Chun Chang, Biljana Jovanović, Paulina Ciepla, Naoko Masumoto, Christopher P Palmer, Edward W Tate, John R Couchman, Anthony I Magee
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e89899 (2014)
Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat
Externí odkaz:
https://doaj.org/article/8f7c265ca69d4979ad7a2c9a0cfe6987
Publikováno v:
Open Biology, Vol 11, Iss 2 (2021)
The syndecans are the major family of transmembrane proteoglycans, usually bearing multiple heparan sulfate chains. They are present on virtually all nucleated cells of vertebrates and are also present in invertebrates, indicative of a long evolution
Externí odkaz:
https://doaj.org/article/a4cb9eb517d54f07a3e350cde6804c19
Autor:
John R. Couchman, Kazutaka Hayashida, Rosemary A. Kozar, Eon Jeong Nam, Pyong Woo Park, Jian Liu, Rafael S. Aquino
Publikováno v:
Hepatology. 66:1601-1615
Accidental or intentional misuse of acetaminophen (APAP) is the leading cause of acute liver failure in the Western world. While mechanisms that trigger APAP-induced liver injury are well known, those that halt the progression of APAP liver disease a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fde1b7353c0013f428754400a3f2141
https://doi.org/10.1002/hep.29265
https://doi.org/10.1002/hep.29265
Publikováno v:
Matrix Biology. :57-69
Cell-extracellular matrix (ECM) and cell-cell junctions that employ microfilaments are sites of tension. They are important for tissue repair, morphogenetic movements and can be emblematic of matrix contraction in fibrotic disease and the stroma of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3016d936aec32344a3d6b465c042305
https://doi.org/10.1016/j.matbio.2016.10.006
https://doi.org/10.1016/j.matbio.2016.10.006
Publikováno v:
Advances in experimental medicine and biology. 1131
In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84e8e2fe2a2f5980dd5e685d4bfe4797
https://pubmed.ncbi.nlm.nih.gov/31646546
https://pubmed.ncbi.nlm.nih.gov/31646546
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030124564
In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c08fe3f17038f673a4c0cad81a025c64
https://doi.org/10.1007/978-3-030-12457-1_43
https://doi.org/10.1007/978-3-030-12457-1_43
Autor:
John R. Couchman
Publikováno v:
Couchman, J R 2019, ' Transforming growth factor-β activation in cell-free extracellular matrix preparations : Commentary ', Folia Histochemica et Cytobiologica, vol. 57, no. 4, pp. 157-158 . https://doi.org/10.5603/FHC.a2019.0017
Transforming growth factor-β (TGF-β) is an important regulator of many cellular and immunological functions. It is often deposited in extracellular matrices in a latent form. This commentary is to draw attention to the likelihood that preparing cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dec1ed34d3e925c084162540e18cf0f
https://curis.ku.dk/portal/da/publications/transforming-growth-factor-activation-in-cellfree-extracellular-matrix-preparations(d8eaa9c7-7e64-45f6-b2f4-591d784432bb).html
https://curis.ku.dk/portal/da/publications/transforming-growth-factor-activation-in-cellfree-extracellular-matrix-preparations(d8eaa9c7-7e64-45f6-b2f4-591d784432bb).html
Autor:
John R. Couchman
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4227, p 4227 (2021)
International Journal of Molecular Sciences
Couchman, J R 2021, ' Syndecan-1 (Cd138), carcinomas and emt ', International Journal of Molecular Sciences, vol. 22, no. 8, 4227 . https://doi.org/10.3390/ijms22084227
International Journal of Molecular Sciences
Couchman, J R 2021, ' Syndecan-1 (Cd138), carcinomas and emt ', International Journal of Molecular Sciences, vol. 22, no. 8, 4227 . https://doi.org/10.3390/ijms22084227
Cell surface proteoglycans are known to be important regulators of many aspects of cell behavior. The principal family of transmembrane proteoglycans is the syndecans, of which there are four in mammals. Syndecan-1 is mostly restricted to epithelia,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca922eedd158cc367f246c951c88164d
https://doi.org/10.3390/ijms22084227
https://doi.org/10.3390/ijms22084227