Zobrazeno 1 - 10
of 1 372
pro vyhledávání: '"John R, Yates"'
Autor:
Ahrum Son, Hyunsoo Kim, Jolene K. Diedrich, Casimir Bamberger, Daniel B. McClatchy, Stuart A. Lipton, John R. Yates
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Mass spectrometry-based methods can provide a global expression profile and structural readout of proteins in complex systems. Preserving the in vivo conformation of proteins in their innate state is challenging during proteomic experiments.
Externí odkaz:
https://doaj.org/article/468f27c4d6e14125b9542495d1d62480
Autor:
Swagata Ghatak, Jolene K. Diedrich, Maria Talantova, Nivedita Bhadra, Henry Scott, Meetal Sharma, Matthew Albertolle, Nicholas J. Schork, John R. Yates III, Stuart A. Lipton
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract Standard single‐cell (sc) proteomics of disease states inferred from multicellular organs or organoids cannot currently be related to single‐cell physiology. Here, a scPatch‐Clamp/Proteomics platform is developed on single neurons gene
Externí odkaz:
https://doaj.org/article/7f4dd02cff274168ba32976ec18c4157
Autor:
Javier Guenaga, Mehrdad Alirezaei, Yu Feng, Mohamad-Gabriel Alameh, Wen-Hsin Lee, Sabyasachi Baboo, Jocelyn Cluff, Richard Wilson, Shridhar Bale, Gabriel Ozorowski, Paulo Lin, Ying Tam, Jolene K. Diedrich, John R. Yates, James C. Paulson, Andrew B. Ward, Drew Weissman, Richard T. Wyatt
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The HIV-1 envelope glycoprotein (Env) is the sole neutralizing determinant on the surface of the virus. The Env gp120 and gp41 subunits mediate receptor binding and membrane fusion and are generated from the gp160 precursor by cellular furins. This c
Externí odkaz:
https://doaj.org/article/37d2ab50b881474f81175ff5bf88cc4e
Autor:
Itabajara da Silva Vaz Junior, Stephen Lu, Antônio F. M. Pinto, Jolene K. Diedrich, John R. Yates, Albert Mulenga, Carlos Termignoni, José Marcos Ribeiro, Lucas Tirloni
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-20 (2024)
Abstract Background When feeding on a vertebrate host, ticks secrete saliva, which is a complex mixture of proteins, lipids, and other molecules. Tick saliva assists the vector in modulating host hemostasis, immunity, and tissue repair mechanisms. Wh
Externí odkaz:
https://doaj.org/article/99fc7c4fd72c4b37aa8e57f0649af10f
Autor:
Ran Song, William McAlpine, Aaron M. Fond, Evan Nair-Gill, Jin Huk Choi, Elisabeth E. L. Nyström, Liisa Arike, Sydney Field, Xiaohong Li, Jeffrey A. SoRelle, James J. Moresco, Eva Marie Y. Moresco, John R. Yates, Parastoo Azadi, Josephine Ni, George M. H. Birchenough, Bruce Beutler, Emre E. Turer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. Using a forward genetic screen, we have fou
Externí odkaz:
https://doaj.org/article/c2c5a71364e54a7780fc6c6274ed1f2e
Autor:
Thu-Thuy Nguyen, Tae Heung Kim, Emily Bencosme-Cuevas, Jacquie Berry, Alex Samuel Kiarie Gaithuma, Moiz Ashraf Ansari, Tae Kwon Kim, Lucas Tirloni, Zeljko Radulovic, James J Moresco, John R Yates, Albert Mulenga
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1012032 (2024)
Lyme disease (LD) caused by Borrelia burgdorferi is among the most important human vector borne diseases for which there is no effective prevention method. Identification of tick saliva transmission factors of the LD agent is needed before the highly
Externí odkaz:
https://doaj.org/article/6061833a4c23447c8ecc79d6e1361558
Autor:
Manabu Kawata, Daniel B. McClatchy, Jolene K. Diedrich, Merissa Olmer, Kristen A. Johnson, John R. Yates, Martin K. Lotz
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Osteoarthritis (OA) is the most common joint disorder, and disease-modifying OA drugs (DMOADs) represent a major need in OA management. Krüppel-like factor 4 (KLF4) is a central transcription factor upregulating regenerative and protective functions
Externí odkaz:
https://doaj.org/article/84f445dd7562469d8561ab051947bdb1
Autor:
Albert Mulenga, Zeljko Radulovic, Lindsay Porter, Taylor Hollman Britten, Tae Kwon Kim, Lucas Tirloni, Alex Kiarie Gaithuma, Grace O. Adeniyi-Ipadeola, Jolene K. Dietrich, James J. Moresco, John R. Yates
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Ixodes scapularis long-term blood feeding behavior is facilitated by a tick secreted bio adhesive (tick cement) that attaches tick mouthparts to skin tissue and prevents the host from dislodging the attached tick. Understanding tick cement f
Externí odkaz:
https://doaj.org/article/b72626fb78f0460ebeeb45641900ac34
Autor:
Julia A. Jones, Na Wei, Haissi Cui, Yi Shi, Guangsen Fu, Navin Rauniyar, Ryan Shapiro, Yosuke Morodomi, Nadine Berenst, Calin Dan Dumitru, Sachiko Kanaji, John R. Yates, III, Taisuke Kanaji, Xiang-Lei Yang
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112632- (2023)
Summary: Various stress conditions are signaled through phosphorylation of translation initiation factor eukaryotic initiation factor 2α (eIF2α) to inhibit global translation while selectively activating transcription factor ATF4 to aid cell surviv
Externí odkaz:
https://doaj.org/article/a0eab927d61c4462b44a1c35a518cd79
Autor:
Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos-Mandujano, Mengge Wang, Muhammad Tehseen, Lorena V. Cortés-Medina, James J. Moresco, Sarah Dunn, Reyna Hernandez-Benitez, Tomoaki Hishida, Na Young Kim, Manal M. Andijani, Chongwei Bi, Manching Ku, Yuta Takahashi, Jinna Xu, Jinsong Qiu, Ling Huang, Christopher Benner, Emi Aizawa, Jing Qu, Guang-Hui Liu, Zhongwei Li, Fei Yi, Yanal Ghosheh, Changwei Shao, Maxim Shokhirev, Patrizia Comoli, Francesco Frassoni, John R. Yates, Xiang-Dong Fu, Concepcion Rodriguez Esteban, Samir Hamdan, Mo Li, Juan Carlos Izpisua Belmonte
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Wiskott-Aldrich syndrome is caused by mutations in WASP, but the underlying mechanisms remain to be explored. Here the authors reveal that WASP deficiency results in aberrant RNA splicing, and that WASP regulates the transcription of splicing factor
Externí odkaz:
https://doaj.org/article/42d4032a62a14197874f6f1fa9c583d6