Zobrazeno 1 - 10
of 125
pro vyhledávání: '"John R, Teijaro"'
Autor:
Alexandra Sakai, Gagandeep Singh, Mahsa Khoshbakht, Scott Bittner, Christiane V. Löhr, Randy Diaz-Tapia, Prajakta Warang, Kris White, Luke Le Luo, Blanton Tolbert, Mario Blanco, Amy Chow, Mitchell Guttman, Cuiping Li, Yiming Bao, Joses Ho, Sebastian Maurer-Stroh, Arnab Chatterjee, Sumit Chanda, Adolfo García-Sastre, Michael Schotsaert, John R. Teijaro, Hong M. Moulton, David A. Stein
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102331- (2024)
Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority. Here, we report that an antisense peptide-conjugated morpholino oligomer (PPMO) named 5′END-2, targeting a highly conserved
Externí odkaz:
https://doaj.org/article/cde8602c5de243599a35a2d086e74e3b
Autor:
Robin C Orozco, Kristi Marquardt, Isaraphorn Pratumchai, Anam Fatima Shaikh, Kerri Mowen, Alain Domissy, John R Teijaro, Linda A Sherman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 3, p e1012095 (2024)
The 1858C>T allele of the tyrosine phosphatase PTPN22 is present in 5-10% of the North American population and is strongly associated with numerous autoimmune diseases. Although research has been done to define how this allele potentiates autoimmunit
Externí odkaz:
https://doaj.org/article/bfa62e36805347e6b0dd0021ea02f00e
Autor:
Veronika Bachanova, Jaroslav Zak, Isaraphorn Pratumchai, Brett S Marro, Kristi L Marquardt, Michael BA Oldstone, Judith A Varner, John R Teijaro
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/998a60fddf0248c3ab997e975e047f6b
Autor:
Jun Xie, Ying Du, Dewang Liu, Jianfeng Wu, Kang Yang, Xiaoyu He, Jiayi Zhao, Peicheng Hong, Kunyu Liao, Huanrong Zhang, Yazhen Hong, John R. Teijaro, Seung Goo Kang, Changchun Xiao, Wen-Hsien Liu
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112968- (2023)
Summary: The miR-17∼92 family microRNAs (miRNAs) play a key role in germinal center (GC) reaction through promoting T follicular helper (TFH) cell differentiation. It remains unclear whether they also have intrinsic functions in B cell differentiat
Externí odkaz:
https://doaj.org/article/4840eac0546146ffbc02268b340bfaf1
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Survival from influenza A virus (IAV) infection largely depends on an intricate balance between pathogen clearance and immunomodulation in the lung. We demonstrate that genetic alteration of the glycan heparan sulfate (HS) in CD11c + cells v
Externí odkaz:
https://doaj.org/article/09c5b7c89e264bfeaa9477debe1c08cb
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cytotoxic CD8 T cells are crucial for the host antigen-specific immune response to viral pathogens. Here we report the identification of an essential role for the serine/arginine-rich splicing factor (SRSF) 1 in CD8 T cell homeostasis and function. S
Externí odkaz:
https://doaj.org/article/4eb2b3e7290e4f54a2a753933679b638
Autor:
Fangzhu Zhao, Celina Keating, Gabriel Ozorowski, Namir Shaabani, Irene M. Francino-Urdaniz, Shawn Barman, Oliver Limbo, Alison Burns, Panpan Zhou, Michael J. Ricciardi, Jordan Woehl, Quoc Tran, Hannah L. Turner, Linghang Peng, Deli Huang, David Nemazee, Raiees Andrabi, Devin Sok, John R. Teijaro, Timothy A. Whitehead, Andrew B. Ward, Dennis R. Burton, Joseph G. Jardine
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104914- (2022)
Summary: The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding
Externí odkaz:
https://doaj.org/article/248cba15fce54b88a8bce360835a4e07
Autor:
Landon J. Edgar, Andrew J. Thompson, Vincent F. Vartabedian, Chika Kikuchi, Jordan L. Woehl, John R. Teijaro, James C. Paulson
Publikováno v:
ACS Central Science, Vol 7, Iss 9, Pp 1508-1515 (2021)
Externí odkaz:
https://doaj.org/article/0aefde61372041928a4d28184a6e753f
Autor:
Malina A. Bakowski, Nathan Beutler, Karen C. Wolff, Melanie G. Kirkpatrick, Emily Chen, Tu-Trinh H. Nguyen, Laura Riva, Namir Shaabani, Mara Parren, James Ricketts, Anil K. Gupta, Kastin Pan, Peiting Kuo, MacKenzie Fuller, Elijah Garcia, John R. Teijaro, Linlin Yang, Debashis Sahoo, Victor Chi, Edward Huang, Natalia Vargas, Amanda J. Roberts, Soumita Das, Pradipta Ghosh, Ashley K. Woods, Sean B. Joseph, Mitchell V. Hull, Peter G. Schultz, Dennis R. Burton, Arnab K. Chatterjee, Case W. McNamara, Thomas F. Rogers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Here, the authors perform repurposing screens of the ReFRAME drug library in two cell lines and identify inhibitors of SARS-CoV-2 infection. Antiviral activity of prodrug MK-4482 is confirmed in hamsters.
Externí odkaz:
https://doaj.org/article/b79629899ac84da0ab6e053c69619b49
Autor:
Namir Shaabani, Vincent F. Vartabedian, Nhan Nguyen, Nadine Honke, Zhe Huang, John R. Teijaro
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss 3, Pp 256-264 (2021)
Externí odkaz:
https://doaj.org/article/580e6183929c4b2cb3d5099ba678b331