Zobrazeno 1 - 10
of 28
pro vyhledávání: '"John R, Soglia"'
Autor:
Jessica J. Lin, Henry E. Pelish, Aaron N. Hata, Monika A. Davare, Viola Zhu, Matthew D. Shair, James R. Porter, Nancy E. Kohl, John R. Soglia, Yuting Sun, Scot Mente, Satoshi Yoda, Katelyn S. Nicholson, Clare Keddy, Adam Acker, Linh Nguyen-Phuong, Anthonie J. van der Wekken, D. Ross Camidge, Shirish M. Gadgeel, Sai-Hong Ignatius Ou, Benjamin Besse, Anupong Tangpeerachaikul, Joshua C. Horan, Alexander Drilon
NVL-520 Modeling, Properties, Biochemical Activity, Cellular Activity, and In Vivo Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179b478fa795d20f06c52f43443d2a80
https://doi.org/10.1158/2159-8290.22542255
https://doi.org/10.1158/2159-8290.22542255
Autor:
Jessica J. Lin, Henry E. Pelish, Aaron N. Hata, Monika A. Davare, Viola Zhu, Matthew D. Shair, James R. Porter, Nancy E. Kohl, John R. Soglia, Yuting Sun, Scot Mente, Satoshi Yoda, Katelyn S. Nicholson, Clare Keddy, Adam Acker, Linh Nguyen-Phuong, Anthonie J. van der Wekken, D. Ross Camidge, Shirish M. Gadgeel, Sai-Hong Ignatius Ou, Benjamin Besse, Anupong Tangpeerachaikul, Joshua C. Horan, Alexander Drilon
ROS1 tyrosine kinase inhibitors (TKI) have been approved (crizotinib and entrectinib) or explored (lorlatinib, taletrectinib, and repotrectinib) for the treatment of ROS1 fusion–positive cancers, although none of them simultaneously address the nee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fc95b4f0ef39c29165338ddd307aa5
https://doi.org/10.1158/2159-8290.c.6549846
https://doi.org/10.1158/2159-8290.c.6549846
Autor:
Alexander Drilon, Joshua C. Horan, Anupong Tangpeerachaikul, Benjamin Besse, Sai-Hong Ignatius Ou, Shirish M. Gadgeel, D. Ross Camidge, Anthonie J. van der Wekken, Linh Nguyen-Phuong, Adam Acker, Clare Keddy, Katelyn S. Nicholson, Satoshi Yoda, Scot Mente, Yuting Sun, John R. Soglia, Nancy E. Kohl, James R. Porter, Matthew D. Shair, Viola Zhu, Monika A. Davare, Aaron N. Hata, Henry E. Pelish, Jessica J. Lin
Publikováno v:
Cancer discovery.
ROS1 tyrosine kinase inhibitors (TKI) have been approved (crizotinib and entrectinib) or explored (lorlatinib, taletrectinib, and repotrectinib) for the treatment of ROS1 fusion–positive cancers, although none of them simultaneously address the nee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7334032e18993114652aa175371035e9
https://pubmed.ncbi.nlm.nih.gov/36511802
https://pubmed.ncbi.nlm.nih.gov/36511802
Autor:
John R. Soglia, Hao Sun, Jonathan N. Bauman, Zhuang Miao, Jianke Li, Angel Guzman-Perez, Kenneth J. DiRico, Tim F. Ryder, Scott W. Bagley, Kosea S. Frederick, Bruce M. Bechle, Sabrina X. Zhao, Michael P. Zawistoski, Daniel P. Walker, Kevin K.-C. Liu, Mary Theresa Didiuk, Amit S. Kalgutkar, Joel Morris, Robert M. Oliver, Ryan Michael Kelley, John William Benbow, David A. Griffith, Chandra Prakash
Publikováno v:
Chemical Research in Toxicology. 23:1115-1126
The synthesis and structure-activity relationship studies on 5-trifluoromethylpyrido[4,3-d]pyrimidin-4(3H)-ones as antagonists of the human calcium receptor (CaSR) have been recently disclosed [ Didiuk et al. ( 2009 ) Bioorg. Med. Chem. Lett. 19 , 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24e5e5f32d0c8dbdd97463c65363b37
https://doi.org/10.1021/tx100137n
https://doi.org/10.1021/tx100137n
Publikováno v:
Rapid Communications in Mass Spectrometry. 23:2146-2150
Propranolol is a widely used quality control and validation compound for liver microsome and hepatocyte metabolism studies. A multitude of literature reports describing the identification of propranolol metabolites exists today. However, no literatur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a55082cb3f8b43a627be9cdbab0e7c9
https://doi.org/10.1002/rcm.4130
https://doi.org/10.1002/rcm.4130
Publikováno v:
Journal of the American Society for Mass Spectrometry. 17:363-375
We report herein, facile metabolite identification workflow on the anti-depressant nefazodone, which is derived from accurate mass measurements based on a single run/experimental analysis. A hybrid LTQ/orbitrap mass spectrometer was used to obtain ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3656d763e5fa69af62aec8642b1839
https://doi.org/10.1016/j.jasms.2005.11.014
https://doi.org/10.1016/j.jasms.2005.11.014
Autor:
John R. Soglia, Sabrina X. Zhao, Amit S. Kalgutkar, Cornelis E.C.A. Hop, Kirk R. Henne, Alfin D. N. Vaz, Mary E. Lame, Claire Collin
Publikováno v:
Chemico-Biological Interactions. 155:10-20
Therapy with the antidepressant trazodone has been associated with several cases of idiosyncratic hepatotoxicity. While the mechanism of hepatotoxicity remains unknown, it is possible that reactive metabolites of trazodone play a causative role. Stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cb63862b250b107932188c45732708
https://doi.org/10.1016/j.cbi.2005.03.036
https://doi.org/10.1016/j.cbi.2005.03.036
Autor:
Mark J. Cole, Shawn Harriman, Sabrina X. Zhao, John R. Soglia, James G. Boyd, Leonard G. Contillo, John T. Barberia
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 36:105-116
An in vitro reactive intermediate screening assay, incorporating the use of the close analog of glutathione, glutathione ethyl ester (GSH-EE) as a conjugating agent, was developed to identify compounds that form reactive intermediates in an in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abcf40857baa17b709d390680a693108
https://doi.org/10.1016/j.jpba.2004.04.019
https://doi.org/10.1016/j.jpba.2004.04.019
Publikováno v:
Chemical Research in Toxicology. 15:551-561
Liquid chromatography with electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) was used to measure DNA adducts of the carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) with a microbore C-18 reversed-phase column. Quantifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510cf0dd41424e89ebe2b13fc5f69dd9
https://doi.org/10.1021/tx010178e
https://doi.org/10.1021/tx010178e
Publikováno v:
Analytical Chemistry. 73:2819-2827
Capillary liquid chromatography/microelectrospray-mass spectrometry (capillary LC/muESI-MS) was used to quantify DNA adducts of the heterocyclic aromatic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in livers of male Fischer-344 rats. Animals r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500f4ab857ad4c8e9b444ecb382d09ce
https://doi.org/10.1021/ac010218j
https://doi.org/10.1021/ac010218j