Zobrazeno 1 - 10
of 113
pro vyhledávání: '"John R, Lever"'
Autor:
Dennis K. Miller, Eric S. Park, Susan Z. Lever, Matthew J. Will, Melissa A. Tapia, John R. Lever
Publikováno v:
Psychopharmacology. 236:3147-3158
Previous research indicates that the selective sigma-1 receptor ligand PD144418 and the selective sigma-2 ligands YUN-252 can inhibit cocaine-induced hyperactivity. The effects of these ligands on other stimulants, such as methamphetamine, have not b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c239b1461a9a1e4bd2a501e46ff67de8
https://doi.org/10.1007/s00213-019-05268-2
https://doi.org/10.1007/s00213-019-05268-2
Publikováno v:
Pharmacological Research. 142:87-100
ABT-737, ABT-263 (Navitoclax) and ABT-199 (Venetoclax) are under intensive preclinical and clinical investigation as treatments for hematologic and other malignancies. These small molecules mimic pro-death B-cell lymphoma-2 (Bcl-2) Homology 3 (BH3) d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9fb2b6f6925eeffc9f074200ed0f20
https://doi.org/10.1016/j.phrs.2019.01.040
https://doi.org/10.1016/j.phrs.2019.01.040
Autor:
Fabio Gallazzi, Lisa D. Watkinson, Emily A. Fergason-Cantrell, Terry L. Carmack, John R. Lever
Publikováno v:
Nuclear Medicine and Biology. 70:53-66
Introduction Peripheral mu (μ) opioid receptors are implicated in pain, bowel dysfunction and the progression of certain cancers. In an effort to identify radioligands well suited for imaging these peripheral sites, we have prepared and evaluated fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a1a9b503ee11c2488bda21c5fb84b71
https://doi.org/10.1016/j.nucmedbio.2019.02.001
https://doi.org/10.1016/j.nucmedbio.2019.02.001
Autor:
Akula Bala Pramod, John R. Lever, Danielle Krout, L. Keith Henry, Michael J. Tomlinson, Roxanne A. Vaughan, Amy Hauck Newman
Publikováno v:
Neurochemistry International. 123:34-45
The dopamine transporter (DAT) is a neuronal membrane protein that is responsible for reuptake of dopamine (DA) from the synapse and functions as a major determinant in control of DA neurotransmission. Cocaine and many psychostimulant drugs bind to D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fab52217f366071b74cf849452af5be5
https://doi.org/10.1016/j.neuint.2018.08.008
https://doi.org/10.1016/j.neuint.2018.08.008
Autor:
Danielle Krout, Akula Bala Pramod, Michael J. Tomlinson, James D. Foster, Rejwi Acharya Dahal, Mu Fa Zou, John R. Lever, L. Keith Henry, Comfort Boatang, Roxanne A. Vaughan, Amy Hauck Newman, Babita Sharma
Publikováno v:
Biochem Pharmacol
Dopamine transporter (DAT) blockers like cocaine and many other abused and therapeutic drugs bind and stabilize an inactive form of the transporter inhibiting reuptake of extracellular dopamine (DA). The resulting increases in DA lead to the ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4cf1746a57566cffa45a5dd17210d46
https://doi.org/10.1016/j.bcp.2017.07.015
https://doi.org/10.1016/j.bcp.2017.07.015
Autor:
Dennis K. Miller, John R. Lever, Emma I. Fullerton, Melissa A. Tapia, Paige C. Hildebrant, Matthew J. Will, Susan Z. Lever, Andrew S. Sage, Jessica M. Judd
Publikováno v:
Psychopharmacology. 237(3)
The N-phenylpropyl-N′-substituted piperazines SA-4503 (N-phenylpropyl-N′-(3,4-dimethoxyphenethyl)piperazine) and YZ-185 (N-phenylpropyl-N′-(3-methoxyphenethyl)piperazine) bind to sigma (σ) receptors and block the development of cocaine-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049b1c54728e7987c170434109d7af13
https://pubmed.ncbi.nlm.nih.gov/31822924
https://pubmed.ncbi.nlm.nih.gov/31822924
Autor:
Melissa A, Tapia, John R, Lever, Susan Z, Lever, Matthew J, Will, Eric S, Park, Dennis K, Miller
Publikováno v:
Psychopharmacology. 236(11)
Previous research indicates that the selective sigma-1 receptor ligand PD144418 and the selective sigma-2 ligands YUN-252 can inhibit cocaine-induced hyperactivity. The effects of these ligands on other stimulants, such as methamphetamine, have not b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::241290fb295697836cc98e5ad6486332
https://pubmed.ncbi.nlm.nih.gov/31139878
https://pubmed.ncbi.nlm.nih.gov/31139878
Publikováno v:
Tetrahedron. 72:6127-6135
Radiolabeled diprenorphine (DPN) and analogs are widely used ligands for non-invasive brain imaging of opioid receptors. To develop complementary radioligands optimized for studies of the peripheral opioid receptors, we prepared a pair of hydrophilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::154cb9fc0a339fec32e3602f2385628f
https://doi.org/10.1016/j.tet.2016.08.015
https://doi.org/10.1016/j.tet.2016.08.015
Autor:
Terry L. Carmack, John R. Lever, Emily A. Fergason-Cantrell, Dennis K. Miller, Lisa D. Watkinson, Susan Z. Lever, Sarah A. Lord, Rong Xu
Publikováno v:
Synapse. 70:98-111
Activation of sigma1 (σ1) receptors contributes to the behavioral and toxic effects of (-)-cocaine. We studied a key step, the ability of (-)-cocaine to occupy σ1 receptors in vivo, using CD-1(®) mice and the novel radioligand [(125) I]E-N-1-(3'-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe0afd6442f6c25398f054b7a51939c6
https://doi.org/10.1002/syn.21877
https://doi.org/10.1002/syn.21877
Autor:
John R, Lever, Emily A, Fergason-Cantrell, Terry L, Carmack, Lisa D, Watkinson, Fabio, Gallazzi
Publikováno v:
Nuclear medicine and biology. 70
INTRODUCTION: Peripheral mu (μ) opioid receptors are implicated in pain, bowel dysfunction and the progression of certain cancers. In an effort to identify radioligands well suited for imaging these peripheral sites, we have prepared and evaluated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9360205fd5f858675dbad705350705d6
https://pubmed.ncbi.nlm.nih.gov/30933866
https://pubmed.ncbi.nlm.nih.gov/30933866