Zobrazeno 1 - 10
of 416
pro vyhledávání: '"John R, Griffiths"'
Autor:
Monika A. Golinska, Marion Stubbs, Adrian L. Harris, Laszlo G. Boros, Madhu Basetti, Dominick J. O. McIntyre, John R. Griffiths
Publikováno v:
Cells, Vol 11, Iss 22, p 3595 (2022)
The HIF-1 and HIF-2 (HIF1/2) hypoxia responses are frequently upregulated in cancers, and HIF1/2 inhibitors are being developed as anticancer drugs. How could cancers resist anti-HIF1/2 therapy? We studied metabolic and molecular adaptations of HIF-1
Externí odkaz:
https://doaj.org/article/ad00fee0952b4adab47fb7890628b765
Publikováno v:
Cells, Vol 10, Iss 9, p 2371 (2021)
In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a broad range of human cancers. HIF inhibitors are under pre-clin
Externí odkaz:
https://doaj.org/article/a985d9e37270413e9fc8e6a34b230116
Autor:
Petros A. Tyrakis, Marie E. Yurkovich, Marco Sciacovelli, Evangelia K. Papachristou, Hannah R. Bridges, Edoardo Gaude, Alexander Schreiner, Clive D’Santos, Judy Hirst, Juan Hernandez-Fernaud, Roger Springett, John R. Griffiths, Christian Frezza
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 1036-1047 (2017)
Summary: Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding its role in tumorigenesis, the effects of FH loss on mitochondrial metabolism are
Externí odkaz:
https://doaj.org/article/abfcb92328ce49b0bf8ea1f46a6357ba
Autor:
Andreas H. Jacobs, Cornelius Faber, John R. Griffiths, Donna-Michelle Smith, Kathrin Heinzmann, Davina J. Honess, Sven Hermann, Lydia Wachsmuth, Annelena Held, Sonja Schelhaas
200 mg/kg gemcitabine affect growth of A549 xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046270ef7ad02677775ae5f1b99da3ae
https://doi.org/10.1158/0008-5472.22413104.v1
https://doi.org/10.1158/0008-5472.22413104.v1
Autor:
Andreas H. Jacobs, Cornelius Faber, John R. Griffiths, Donna-Michelle Smith, Kathrin Heinzmann, Davina J. Honess, Sven Hermann, Lydia Wachsmuth, Annelena Held, Sonja Schelhaas
Mean and standard deviation, as well as number of samples analyzed (in brackets), of other PET image quantification approaches.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac14323743cfeb8e9699a24a1a0d57d
https://doi.org/10.1158/0008-5472.22413098.v1
https://doi.org/10.1158/0008-5472.22413098.v1
Autor:
Andreas H. Jacobs, Cornelius Faber, John R. Griffiths, Donna-Michelle Smith, Kathrin Heinzmann, Davina J. Honess, Sven Hermann, Lydia Wachsmuth, Annelena Held, Sonja Schelhaas
Legends for Supplementary Figures S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b121c4992613de4350ddcc74b8961d3e
https://doi.org/10.1158/0008-5472.22413101.v1
https://doi.org/10.1158/0008-5472.22413101.v1
Autor:
Andreas H. Jacobs, Cornelius Faber, John R. Griffiths, Donna-Michelle Smith, Kathrin Heinzmann, Davina J. Honess, Sven Hermann, Lydia Wachsmuth, Annelena Held, Sonja Schelhaas
3′-Deoxy-3′-[18F]fluorothymidine positron emission tomography ([18F]FLT-PET) and diffusion-weighted MRI (DW-MRI) are promising approaches to monitor tumor therapy response. Here, we employed these two imaging modalities to evaluate the response o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93eb25f06efa2a5c6a0f1fb68b7b8cec
https://doi.org/10.1158/0008-5472.c.6508619.v1
https://doi.org/10.1158/0008-5472.c.6508619.v1
Autor:
Yuen-Li Chung, Martin O. Leach, Paul Workman, Ian R. Judson, John R. Griffiths, Geoffrey S. Payne, L. Elizabeth Jackson, Anne-Christine Wong Te Fong, Robert H. te Poele, Helen Troy, Vaitha Arunan, Mounia Beloueche-Babari
PDF file - 94K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b201863ffa2a317715ddd37713491b39
https://doi.org/10.1158/0008-5472.22393601
https://doi.org/10.1158/0008-5472.22393601
Autor:
Jennifer D. Wu, Gary E. Schiltz, Lakshmi Reddy Bollu, Simon J. Clark, Peiwen Chen, Brian Wray, Kristen L. Lauing, Riyue Bao, Craig Horbinski, Erik Ladomersky, Rajesh Acharya, April Bell, Miri Kim, Richard D. Unwin, Matthew J. Schipma, Rimas V. Lukas, Matthew Genet, Derek A. Wainwright, Lijie Zhai, John R. Griffiths, Xinlei Mi, Brenda Nguyen
Publikováno v:
Clin Cancer Res
Purpose: Glioblastoma (GBM) is an incurable primary brain tumor that has not benefited from immunotherapy to date. More than 90% of GBM expresses the tryptophan (Trp) metabolic enzyme, indoleamine 2,3-dioxygenase 1 (IDO). This observation supported t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb3cd18f037b33ffc3e757f421dbba6
https://doi.org/10.1158/1078-0432.ccr-21-1392
https://doi.org/10.1158/1078-0432.ccr-21-1392
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185980 (2017)
We quantified 378 HRMAS 1H NMR spectra of human brain tumours (132 glioblastomas, 101 astrocytomas, 75 meningiomas, 37 oligodendrogliomas and 33 metastases) from the eTumour database and looked for metabolic interactions by metabolite-metabolite corr
Externí odkaz:
https://doaj.org/article/b82f4838af384f389b65868d22141c26