Zobrazeno 1 - 10
of 199
pro vyhledávání: '"John R, Gordon"'
Deficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model
Autor:
Nguyen Phuong Khanh Le, Amanda Florentina do Nascimento, David Schneberger, Chi Cuong Quach, Xiaobei Zhang, Gurpreet K. Aulakh, Wojciech Dawicki, Lixin Liu, John R. Gordon, Baljit Singh
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background Asthma is a major cause of morbidity and mortality in humans. The mechanisms of asthma are still not fully understood. Leukocyte-specific protein-1 (LSP-1) regulates neutrophil migration during acute lung inflammation. However, it
Externí odkaz:
https://doaj.org/article/7a8fdf3e6f404519a763a081af87edde
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Dendritic cells (DC) are antigen-presenting cells that can communicate with T cells both directly and indirectly, regulating our adaptive immune responses against environmental and self-antigens. Under some microenvironmental conditions DC develop in
Externí odkaz:
https://doaj.org/article/affd71d2199c40f28dcd8e29d4d8d42b
Autor:
Wojciech Dawicki, Hui Huang, Yanna Ma, Jennifer Town, Xiaobei Zhang, Chris D Rudulier, John R Gordon
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0248290 (2021)
CD40 expressed on stimulatory dendritic cells (DC) provides an important accessory signal for induction of effector T cell responses. It is also expressed at lower levels on regulatory DC (DCreg), but there is little evidence that CD40 signaling cont
Externí odkaz:
https://doaj.org/article/cefac9de362b49cd89ae401f25f07e2f
Autor:
Jing-Jing Wang, Walana Williams, Bing Wang, Jing Wei, Xia Lu, Jya-Wei Cheng, John R Gordon, Jing-Min Li, Fang Li
Publikováno v:
International Journal of Ophthalmology, Vol 11, Iss 8, Pp 1277-1283 (2018)
AIM: To investigate the effect of interleukin-8 (IL-8) on neural retinal ganglion cells (RGCs) and whether it can be alleviated by G31P. METHODS: RGC-5 cells were exposed to IL-8 with or without its specific receptor antagonist G31P for 24h, and the
Externí odkaz:
https://doaj.org/article/e19bf66acb0b4b2d98f4af7b66c463af
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190414 (2018)
IL-10-differentiated dendritic cells (DC10) can reverse the asthma phenotype in mice, but how they suppress the asthmatic B cell response is unclear. Herein we assessed the mechanism(s) by which DC10 and DC10-induced Treg affect IgG1 production in as
Externí odkaz:
https://doaj.org/article/66b455ad47fb43cb9ea8cee61756009e
Autor:
Gerald Davies, Liubov Lobanova, Wojciech Dawicki, Gary Groot, John R Gordon, Matthew Bowen, Troy Harkness, Terra Arnason
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0187191 (2017)
Multiple drug resistant (MDR) malignancy remains a predictable and often terminal event in cancer therapy, and affects individuals with many cancer types, regardless of the stage at which they were originally diagnosed or the interval from last treat
Externí odkaz:
https://doaj.org/article/ba5d6e3402594ca89ad0c159a072388e
Publikováno v:
AIMS Allergy and Immunology. 5:73-91
IL-10-induced DC (DC10) secrete IL-10, thereby promoting aeroallergen tolerance by activation of CD25+Foxp3+ Treg, while retinoic acid-induced DC (DC-RA) foster food allergen tolerance via IL-27-dependent induction of Foxp3− Treg. In some respects,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d1c5a08fcfcdb9beb12ade792b3f9d
https://doi.org/10.3934/allergy.2021007
https://doi.org/10.3934/allergy.2021007
Autor:
Adam M. Huber, Anthony Kusalik, Roman Jurencak, Daniel J. Hogan, Susan Tupper, Shirley M. L. Tse, Lynn Spiegel, Ciarán M. Duffy, Rosie Scuccimarri, Stephen W. Scherer, Kimberly Morishita, Suzanne E. Ramsey, Jaime Guzman, Kristin Houghton, Regina M. Taylor-Gjevre, Elizabeth Stringer, John R. Gordon, Ronald M. Laxer, Bianca Lang, David A. Cabral, Richard F. Wintle, Paul Dancey, Alan M. Rosenberg, Brett Trost, Sarah Campillo, Gilles Boire, Simon W. M. Eng, Kiem Oen, Elham Rezaei, Stuart E. Turvey, Rae S. M. Yeung, Anne-Laure Chetaille, Ross E. Petty, Lori B. Tucker, Karen Watanabe Duffy, Gaëlle Chédeville
Publikováno v:
Rheumatology. 59:1066-1075
Objective To identify discrete clusters comprising clinical features and inflammatory biomarkers in children with JIA and to determine cluster alignment with JIA categories. Methods A Canadian prospective inception cohort comprising 150 children with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb151401a2f552871c1adc7e97e1df2
https://doi.org/10.1093/rheumatology/kez382
https://doi.org/10.1093/rheumatology/kez382
Publikováno v:
Molecules, Vol 22, Iss 7, p 1229 (2017)
The ELR-CXC chemokines are important to neutrophil inflammation in many acute and chronic diseases. Among them, CXCL8 (interleukin-8, IL-8), the expression levels of which are elevated in many inflammatory diseases, binds to both the CXCR1 and CXCR2
Externí odkaz:
https://doaj.org/article/8566baa2471649a29d335e1f567eedb9
Autor:
Omar S. Qureshi, Fay Stewart, Andrew C Robinson, Charlotte Ferris, Nicholas M. Barnes, Zania Stamataki, Sebastian T Lugg, Aaron Scott, Tina Tang, Gerald Langman, Chiara Pallini, John R. Gordon, Thomas Pinkney, Alexander Roberts, Lindsay Bentley, David R Thickett, S. John Curnow, A.J Cooper, Graham S. Taylor, Kristian Brock, Bridget Hemming, Catherine A. Brady, Hollie Bancroft, Joanne Chapman, Babu Naidu, Joel Juvvanapudi, Graham R. Wallace
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Blockade of PD-1/PD-L1 interactions is proving an exciting, durable therapeutic modality in a range of cancers whereby T cells are released from checkpoint inhibition to revive their inherent anti-tumour activity. Here we have studied various ways to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d080e0bed706b07d23b8995acc8c24f2
https://doi.org/10.1038/s41598-021-83612-3
https://doi.org/10.1038/s41598-021-83612-3