Zobrazeno 1 - 10
of 1 003
pro vyhledávání: '"John R, Falck"'
Autor:
Iwona Baranowska, Olga Gawrys, Agnieszka Walkowska, Krzysztof H. Olszynski, Luděk Červenka, John R. Falck, Adeniyi M. Adebesin, John D. Imig, Elżbieta Kompanowska-Jezierska
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Numerous studies indicate a significant role for cytochrome P-450-dependent arachidonic acid metabolites in blood pressure regulation, vascular tone, and control of renal function. Epoxyeicosatrienoic acids (EETs) exhibit a spectrum of beneficial eff
Externí odkaz:
https://doaj.org/article/b9fdeecb898742bbaf432726db2343fc
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 783 (2023)
In Dahl salt-sensitive (SS) rats, impaired vascular relaxation can be restored by: (1) minipump infusion of a low (sub-pressor) dose of angiotensin II (ANG II) to restore physiological levels of plasma ANG II, (2) inhibition of 20-HETE production, an
Externí odkaz:
https://doaj.org/article/d8032ec33efa47f0ba2389ffb3712585
Autor:
Ranran Han, Jieru Wan, Xiaoning Han, Honglei Ren, John R. Falck, Sailu Munnuri, Zeng-Jin Yang, Raymond C. Koehler
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Intracerebral hemorrhage (ICH) is a highly fatal type of stroke that leads to various types of neuronal death. Recently, ferroptosis, a form of cell death resulting from iron-dependent lipid peroxide accumulation, was observed in a mouse ICH model. N
Externí odkaz:
https://doaj.org/article/55de5826e0c9473c9899c4cdf2c5f2fe
Autor:
Agnieszka Walkowska, Luděk Červenka, John D. Imig, John R. Falck, Janusz Sadowski, Elżbieta Kompanowska-Jezierska
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Cytochrome P450 (CYP-450) metabolites of arachidonic acid: epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) have established role in regulation of blood pressure (BP) and kidney function. EETs deficiency and increased re
Externí odkaz:
https://doaj.org/article/08d463db50a1474aab1220eec86554a3
Autor:
Jorge H. Capdevila, John R. Falck
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 11, Pp 2047-2062 (2018)
The initial studies of the metabolism of arachidonic acid (AA) by the cytochrome P450 (P450) hemeproteins sought to: a) elucidate the roles for these enzymes in the metabolism of endogenous pools of the FA, b) identify the P450 isoforms involved in A
Externí odkaz:
https://doaj.org/article/067194c7a90b4c78984e3ec2e7a83202
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 4, Pp 615-624 (2018)
Polarization of macrophages to proinflammatory M1 and to antiinflammatory alternatively activated M2 states has physiological implications in the development of experimental hypertension and other pathological conditions. 12/15-Lipoxygenase (12/15-LO
Externí odkaz:
https://doaj.org/article/5457e9c1716b4d4eb9fdb5d09d1751f0
Autor:
Petr Kala, Matúš Miklovič, Šárka Jíchová, Petra Škaroupková, Zdeňka Vaňourková, Hana Maxová, Olga Gawrys, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, John D. Imig, John R. Falck, Josef Veselka, Luděk Červenka, Renáta Aiglová, Marek Vícha, Vít Gloger, Miloš Táborský
Publikováno v:
Biomedicines, Vol 9, Iss 8, p 1053 (2021)
This study evaluates the effects of chronic treatment with EET-A, an orally active epoxyeicosatrienoic acid (EETs) analog, on the course of aorto-caval fistula (ACF)-induced heart failure (HF) in Ren-2 transgenic rats (TGR), a model characterized by
Externí odkaz:
https://doaj.org/article/fc2f287a685341ddac7eacebb22f42da
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disorder that causes life threatening renal disease and current therapies are limited with serious side-effects. CYP epoxygenase metabolites of arachidonic acid epoxyeicosatrieno
Externí odkaz:
https://doaj.org/article/bfd02d1e226249579059064ab914c69e
Autor:
Jaroslav Hrdlička, Jan Neckář, František Papoušek, Zuzana Husková, Soňa Kikerlová, Zdenka Vaňourková, Zdenka Vernerová, Firat Akat, Jana Vašinová, Bruce D. Hammock, Sung Hee Hwang, John D. Imig, John R. Falck, Luděk Červenka, František Kolář
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Epoxyeicosatrienoic acids (EETs) and their analogs have been identified as potent antihypertensive compounds with cardio- and renoprotective actions. Here, we examined the effect of EET-A, an orally active EET analog, and c-AUCB, an inhibitor of the
Externí odkaz:
https://doaj.org/article/c98a38c7fda04e4a81194d59e2fbbc8c
Autor:
Juan A, Azcona, Samantha, Tang, Elizabeth, Berry, Frank F, Zhang, Radha, Garvey, John R, Falck, Michal Laniado, Schwartzman, Tao, Yi, Thomas M, Jeitner, Austin M, Guo
Publikováno v:
J Pharmacol Exp Ther
Compensatory angiogenesis is an important adaptation for recovery from critical ischemia. We recently identified 20-hydroxyeicosatetraenoic acid (20-HETE) as a novel contributor of ischemia-induced angiogenesis. However, the precise mechanisms by whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595794d0963eda57adce6a9d9a0c7639
https://doi.org/10.1124/jpet.121.001036
https://doi.org/10.1124/jpet.121.001036