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pro vyhledávání: '"John Quin"'
Autor:
John Quin
Video is everywhere. But what is video art and how does it differ from cinema? What connections has it made with healthcare and medicine? And what implications might these connections have for how we approach our physical and mental health? Breaking
Autor:
John Quin
Publikováno v:
Clinical Medicine. 14:667-669
The co-existence of diabetes mellitus and HIV infection poses significant challenges for both patient and physician. This article reviews the clinical problems, the implications for treatment plans and potential confusions that can arise when managin
Autor:
Charles Zammit, Anita Wale, Barnaby Edward Young, Sabina Dizdarevic, Kenneth A. Miles, John Quin, Anthony Williams
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 41:105-115
Purpose Fine-needle aspiration (FNA) has revolutionised the care of patients with thyroid nodules and is the initial investigation of choice. However, as a result of nondiagnostic (Thy1) and nonneoplastic (Thy2) specimens, it remains an imperfect sol
Publikováno v:
Clinical Medicine. 13:136-140
Erectile dysfunction (ED) affects millions of men worldwide with implications that go far beyond sexual activity. ED is now recognised as an early marker of cardiovascular disease, diabetes mellitus (DM) and depression. The risk factors that are asso
Autor:
Cornel Catana, Lisa A. Perrin, Jeff Ohren, Jeremy J. Edmunds, John Quin, Derek James Sheehan, Sangita M. Baxi, Jennifer K. Hoffman, Jeffrey T. Kohrt, Amy M. Delaney, Fred L. Ciske, Michael Kaufman, Noel A. Powell, Patrick I. McConnell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1046-1050
We report the SAR around a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. 2-Aminophenethyl analogs demonstrate excellent potency but moderate kinase selectivity, while 2-aminobenzyl analogs that fill the Ala571 subpocket exhi
Autor:
Ellen M. Dobrusin, Elizabeth A. Lunney, William A. Denny, Edward N. Baker, Andrew M. Thompson, R. John Booth, Brian D. Palmer, John Quin, Alan J. Kraker, Christopher J. Squire, Ivan Ivanovic, Daniel F. Ortwine, Ho H. Lee, Jeff B. Smaill, James M. J. Dickson, Alexander James Bridges
Publikováno v:
European Journal of Medicinal Chemistry. 43:1276-1296
A series of N-6 substituted 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones were prepared from N-substituted (5-methoxyphenyl)ethenylindoles. The target compounds were tested for their ability to inhibit the G2/M cell cycle checkpoint kin
Autor:
Daniel F. Ortwine, Nadia Esmaeil, Haile Tecle, John Quin, Joseph S. Warmus, Michael Kaufman, William A. Denny, Jeffrey F. Ohren, and Alexander G. Pavlovsky, Ronald L. Merriman, Jared B. J. Milbank, Aurash B. Shahripour, Shannon Leigh Black, Judith Sebolt-Leopold, Christopher Whitehead, Julie Ann Spicer, Cathlin Marie Flamme, Heidi S. Camp, Kelley Moore, Richard Gowan, Charles Omer, Mark Stephen Plummer, Sally Pryzbranowski, Gordon W. Rewcastle, Stephen Douglas Barrett
Publikováno v:
Journal of Medicinal Chemistry. 50:5090-5102
A new series of MEK1 inhibitors, the 4-anilino-5-carboxamido-2-pyridones, were designed and synthesized using a combination of medicinal chemistry, computational chemistry, and structural elucidation. The effect of variation in the carboxamide side c
Autor:
John Quin, Peter L. Toogood, Ellen Myra Dobrusin, R. John Booth, William Elliott, Scott Norman Vanderwel, Patricia J. Harvey, Joseph Thomas Repine, Paul R. Keller, David W. Fry, Dennis Joseph Mcnamara
Publikováno v:
Journal of Medicinal Chemistry. 48:2371-2387
Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide an effective method for the treatment of proliferative diseases such as cancer. The pyrido[2,3-d]pyrimidin-7-one template has been identified previously as
Publikováno v:
Endocrine Abstracts.