Zobrazeno 1 - 10
of 202
pro vyhledávání: '"John Q Wang"'
Autor:
John Q Wang, Xiang-Ping eChu, Ming-Lei eGuo, Dao-Zhong eJin, Bing eXue, Thomas J Berry, Eugene E Fibuch, Li-Min eMao
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
Ionotropic glutamate receptors (iGluR) are ligand-gated ion channels and are densely expressed in broad areas of mammalian brains. Like iGluRs, acid-sensing ion channels (ASIC) are ligand (H+)-gated channels and are enriched in brain cells and periph
Externí odkaz:
https://doaj.org/article/a7098ced30a744a58d7e1d2f7c5883c2
Publikováno v:
Frontiers in Neuroanatomy, Vol 5 (2011)
Posttranslational covalent modifications of glutamate receptors remain a hot topic. Early studies have established that this family of receptors, including almost all ionotropic and metabotropic glutamate receptor subtypes, undergoes active phosphory
Externí odkaz:
https://doaj.org/article/28b07109106047869f3738706a1ad24d
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2024)
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins. Accumulating evidence
Externí odkaz:
https://doaj.org/article/fcd8ec3982c746f8a704e59d36f70fea
Publikováno v:
IBRO Neuroscience Reports, Vol 13, Iss , Pp 22-30 (2022)
Major depressive disorder is a common and serious mood illness. The molecular mechanisms underlying the pathogenesis and symptomatology of depression are poorly understood at present. Multiple neurotransmitter systems are believed to be implicated in
Externí odkaz:
https://doaj.org/article/1fc574edc78547f8acac7e5afa4ed8e7
Autor:
Li‐Min Mao, John Q. Wang
Publikováno v:
Brain and Behavior, Vol 10, Iss 3, Pp n/a-n/a (2020)
Abstract Objective The adenosine A1 receptor is a Gαi/o protein‐coupled receptor and inhibits upon activation cAMP formation and protein kinase A (PKA) activity. As a widely expressed receptor in the mammalian brain, A1 receptors are implicated in
Externí odkaz:
https://doaj.org/article/15641756e3cf4844acd236767c14420c
Publikováno v:
Journal of Molecular Neuroscience. 72:802-811
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f0c0f0a96f4fb243d0c7b395ea56ac1
https://doi.org/10.1007/s12031-021-01961-0
https://doi.org/10.1007/s12031-021-01961-0
Publikováno v:
Frontiers in psychiatry. 13
There are more than 200 opioid overdose deaths each day in the US. In combating this epidemic we look to available treatment tools. Here, we find only three medications approved by the Food and Drug Administration (FDA) for the treatment of opioid us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d589d690565095f4fae00287d41ad9b0
https://pubmed.ncbi.nlm.nih.gov/36386988
https://pubmed.ncbi.nlm.nih.gov/36386988
Publikováno v:
Frontiers in cell and developmental biology. 10
Group II metabotropic glutamate (mGlu) receptors (mGlu2/3) are Gαi/o-coupled receptors and are primarily located on presynaptic axonal terminals in the central nervous system. Like ionotropic glutamate receptors, group II mGlu receptors are subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0427e95948d811a623f3289bca59bcb
https://pubmed.ncbi.nlm.nih.gov/36407098
https://pubmed.ncbi.nlm.nih.gov/36407098
Autor:
Limin Mao, John Q. Wang
Publikováno v:
Neuroscience
The Src family kinase (SFK) is a subfamily of non-receptor tyrosine kinases. The SFK member Fyn is enriched at synaptic sites in the limbic reward circuit and plays a pivotal role in the regulation of glutamate receptors. In this study, we investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0944525e6af4618d5c2d0d8f913a985a
https://doi.org/10.1016/j.neuroscience.2020.02.048
https://doi.org/10.1016/j.neuroscience.2020.02.048
Autor:
Miao Tian, Chongshen Kuang, Tao-Tao Liu, Yiyun Cao, Yue Li, Cheng Ni, John Q. Wang, Xinning Mi, Xiangyang Guo, Zhengqian Li, Dengyang Han, Jindan He, Lunxu Li, Ning Yang
Publikováno v:
Aging (Albany NY)
Stress-induced α-synuclein aggregation, especially the most toxic species (oligomers), may precede synaptic and cognitive dysfunction. Under pathological conditions, α-synuclein is degraded primarily through the autophagic/lysosomal pathway. We ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adad70c57f8af5d450fb73c5443c354c
https://doi.org/10.18632/aging.103074
https://doi.org/10.18632/aging.103074