Zobrazeno 1 - 10
of 16
pro vyhledávání: '"John Plat"'
Autor:
Matthew Moll, Julian Hecker, John Platig, Jingzhou Zhang, Auyon J. Ghosh, Katherine A. Pratte, Rui-Sheng Wang, Davin Hill, Iain R. Konigsberg, Joe W. Chiles, III, Craig P. Hersh, Peter J. Castaldi, Kimberly Glass, Jennifer G. Dy, Don D. Sin, Ruth Tal-Singer, Majd Mouded, Stephen I. Rennard, Gary P. Anderson, Gregory L. Kinney, Russell P. Bowler, Jeffrey L. Curtis, Merry-Lynn McDonald, Edwin K. Silverman, Brian D. Hobbs, Michael H. Cho
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105429- (2024)
Summary: Background: Genetic variants and gene expression predict risk of chronic obstructive pulmonary disease (COPD), but their effect on COPD heterogeneity is unclear. We aimed to define high-risk COPD subtypes using genetics (polygenic risk score
Externí odkaz:
https://doaj.org/article/a0549eb45ebc4c8e9d1d5f0c4da19d8b
Autor:
Marouen Ben Guebila, Tian Wang, Camila M. Lopes-Ramos, Viola Fanfani, Des Weighill, Rebekka Burkholz, Daniel Schlauch, Joseph N. Paulson, Michael Altenbuchinger, Katherine H. Shutta, Abhijeet R. Sonawane, James Lim, Genis Calderer, David G.P. van IJzendoorn, Daniel Morgan, Alessandro Marin, Cho-Yi Chen, Qi Song, Enakshi Saha, Dawn L. DeMeo, Megha Padi, John Platig, Marieke L. Kuijjer, Kimberly Glass, John Quackenbush
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Inference and analysis of gene regulatory networks (GRNs) require software that integrates multi-omic data from various sources. The Network Zoo (netZoo; netzoo.github.io) is a collection of open-source methods to infer GRNs, conduct differe
Externí odkaz:
https://doaj.org/article/01292b2a2c0c4ab587bb305ea80549fe
Autor:
Albert T. Young, Xavier Carette, Michaela Helmel, Hanno Steen, Robert N. Husson, John Quackenbush, John Platig
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract The ability of Mycobacterium tuberculosis (Mtb) to adapt to diverse stresses in its host environment is crucial for pathogenesis. Two essential Mtb serine/threonine protein kinases, PknA and PknB, regulate cell growth in response to environm
Externí odkaz:
https://doaj.org/article/2df1222b97bb43faa8f378b2567a1374
Autor:
Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009912 (2021)
α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in
Externí odkaz:
https://doaj.org/article/a9364620e0274197ae0b0ec2bcff504b
Autor:
Deborah Weighill, Marouen Ben Guebila, Kimberly Glass, John Platig, Jen Jen Yeh, John Quackenbush
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Profiling of whole transcriptomes has become a cornerstone of molecular biology and an invaluable tool for the characterization of clinical phenotypes and the identification of disease subtypes. Analyses of these data are becoming ever more sophistic
Externí odkaz:
https://doaj.org/article/f80fed3301524b179e7e1c5d0f7d9166
Autor:
Jumei Zeng, John Platig, Tan-Yun Cheng, Saima Ahmed, Yara Skaf, Lakshmi-Prasad Potluri, Daniel Schwartz, Hanno Steen, D Branch Moody, Robert N Husson
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008452 (2020)
The Mycobacterium tuberculosis Ser/Thr protein kinases PknA and PknB are essential for growth and have been proposed as possible drug targets. We used a titratable conditional depletion system to investigate the functions of these kinases. Depletion
Externí odkaz:
https://doaj.org/article/f6cb6ba14db54df4a334994a81d456e5
Autor:
Joseph D. Barry, Maud Fagny, Joseph N. Paulson, Hugo J.W.L. Aerts, John Platig, John Quackenbush
Publikováno v:
iScience, Vol 5, Iss , Pp 80-89 (2018)
Summary: Genotype-to-phenotype association studies typically use macroscopic physiological measurements or molecular readouts as quantitative traits. There are comparatively few suitable quantitative traits available between cell and tissue length sc
Externí odkaz:
https://doaj.org/article/f0bffe5eb0ef4f57bf0249df0c9d5706
Autor:
Jarrett D. Morrow, Michael H. Cho, John Platig, Xiaobo Zhou, Dawn L. DeMeo, Weiliang Qiu, Bartholome Celli, Nathaniel Marchetti, Gerard J. Criner, Raphael Bueno, George R. Washko, Kimberly Glass, John Quackenbush, Edwin K. Silverman, Craig P. Hersh
Publikováno v:
Human Genomics, Vol 12, Iss 1, Pp 1-12 (2018)
Abstract Background Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) significantly associated with chronic obstructive pulmonary disease (COPD). However, many genetic variants show suggestive evidence for
Externí odkaz:
https://doaj.org/article/7085fdbf22e64eb5aa56cce5f933b293
Autor:
Abhijeet Rajendra Sonawane, John Platig, Maud Fagny, Cho-Yi Chen, Joseph Nathaniel Paulson, Camila Miranda Lopes-Ramos, Dawn Lisa DeMeo, John Quackenbush, Kimberly Glass, Marieke Lydia Kuijjer
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 1077-1088 (2017)
Summary: Although all human tissues carry out common processes, tissues are distinguished by gene expression patterns, implying that distinct regulatory programs control tissue specificity. In this study, we investigate gene expression and regulation
Externí odkaz:
https://doaj.org/article/4fc4812063d64b9ab5c0bbd242fb457f
Autor:
Joseph N. Paulson, Cho-Yi Chen, Camila M. Lopes-Ramos, Marieke L. Kuijjer, John Platig, Abhijeet R. Sonawane, Maud Fagny, Kimberly Glass, John Quackenbush
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-10 (2017)
Abstract Background Although ultrahigh-throughput RNA-Sequencing has become the dominant technology for genome-wide transcriptional profiling, the vast majority of RNA-Seq studies typically profile only tens of samples, and most analytical pipelines
Externí odkaz:
https://doaj.org/article/39492d2dc8214268be55238a0b71829a