Zobrazeno 1 - 10
of 72
pro vyhledávání: '"John Paul SanGiovanni"'
Autor:
Eszter Emri, Oisin Cappa, Caoimhe Kelly, Elod Kortvely, John Paul SanGiovanni, Brian S. McKay, Arthur A. Bergen, David A. Simpson, Imre Lengyel
Publikováno v:
Cells, Vol 12, Iss 5, p 773 (2023)
Zinc supplementation has been shown to be beneficial to slow the progression of age-related macular degeneration (AMD). However, the molecular mechanism underpinning this benefit is not well understood. This study used single-cell RNA sequencing to i
Externí odkaz:
https://doaj.org/article/3ed1ecb4cff647cbad6eee0dd785ff03
Autor:
Zhongjie Fu, Wenjun Yan, Chuck T. Chen, Anders K. Nilsson, Edward Bull, William Allen, Jay Yang, Minji Ko, John Paul SanGiovanni, James D. Akula, Saswata Talukdar, Ann Hellström, Lois E. H. Smith
Publikováno v:
Nutrients, Vol 14, Iss 7, p 1333 (2022)
There is a gap in understanding the effect of the essential ω-3 and ω-6 long-chain polyunsaturated fatty acids (LCPUFA) on Phase I retinopathy of prematurity (ROP), which precipitates proliferative ROP. Postnatal hyperglycemia contributes to Phase
Externí odkaz:
https://doaj.org/article/7a0ab7c11ae040338b4a7dad9bb71a1e
Autor:
Yan Gong, Zhuo Shao, Zhongjie Fu, Matthew L. Edin, Ye Sun, Raffael G. Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Samuel B. Burnim, Steven S. Meng, Fred B. Lih, John Paul SanGiovanni, Darryl C. Zeldin, Ann Hellström, Lois E.H. Smith
Publikováno v:
EBioMedicine, Vol 13, Iss C, Pp 201-211 (2016)
Neovascular eye diseases including retinopathy of prematurity, diabetic retinopathy and age-related-macular-degeneration are major causes of blindness. Fenofibrate treatment in type 2 diabetes patients reduces progression of diabetic retinopathy inde
Externí odkaz:
https://doaj.org/article/9ac54728e7dc4d9d8242e2c51cca0289
Publikováno v:
Nutrients, Vol 12, Iss 5, p 1333 (2020)
Diet-based xanthophylls (zeaxanthin and lutein) are conditionally essential polar carotenoids preferentially accreted in high concentrations (1 mM) to the central retina, where they have the capacity to impart unique physiologically significant bioph
Externí odkaz:
https://doaj.org/article/4f44b340c28145e79b32be7271715b20
Autor:
John Paul SanGiovanni, Jing Chen, Ankur S Gupta, Lois E H Smith, Przemyslaw Sapieha, Phil H Lee
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125548 (2015)
We conducted a nested candidate gene study and pathway-based enrichment analysis on data from a multi-national 77,000-person project on the molecular genetics of age-related macular degeneration (AMD) to identify AMD-associated DNA-sequence variants
Externí odkaz:
https://doaj.org/article/0a30bc5b3e1147eda263fd809d40804e
Autor:
John Paul SanGiovanni, Phil H Lee
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71239 (2013)
PURPOSE: To determine whether common DNA sequence variants within groups of genes encoding elements of stress-activated mitogen-activated protein kinase (MAPK) signaling pathways are, in aggregate, associated with advanced AMD (AAMD). METHODS: We use
Externí odkaz:
https://doaj.org/article/40631dd0c0dd4f57a60d9f6dfd69b59e
Autor:
John Paul SanGiovanni, Jing Chen, Przemyslaw Sapieha, Christopher M Aderman, Andreas Stahl, Traci E Clemons, Emily Y Chew, Lois E H Smith
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53155 (2013)
Increased intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) and use of peroxisome proliferator activator receptor (PPAR)-activating drugs are associated with attenuation of pathologic retinal angiogenesis. ω-3 LCPUFAs are endogenous ag
Externí odkaz:
https://doaj.org/article/f19ea9ba486a443f84bac2dd10193ac2
Autor:
John Paul SanGiovanni, Dan E Arking, Sudha K Iyengar, Michael Elashoff, Traci E Clemons, George F Reed, Alice K Henning, Theru A Sivakumaran, Xuming Xu, Andrew DeWan, Elvira Agrón, Elena Rochtchina, Carolyn M Sue, Jie Jin Wang, Paul Mitchell, Josephine Hoh, Peter J Francis, Michael L Klein, Emily Y Chew, Aravinda Chakravarti
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5508 (2009)
BACKGROUND:Age-related macular degeneration (AMD), a chronic neurodegenerative and neovascular retinal disease, is the leading cause of blindness in elderly people of western European origin. While structural and functional alterations in mitochondri
Externí odkaz:
https://doaj.org/article/d40c937c569d4bf7ba0d69e60ad70004
Autor:
Chi-Hsiu Liu, Felix Yemanyi, Kiran Bora, Neetu Kushwah, Alexandra K. Blomfield, Theodore M. Kamenecka, John Paul SanGiovanni, Ye Sun, Laura A. Solt, Jing Chen
Publikováno v:
Aging. 15:37-52
Autor:
Eszter Emri, Oisin Cappa, Caoimhe Kelly, Elod Kortvely, John Paul SanGiovanni, Brian S. McKay, Arthur A. Bergen, David A. Simpson, Imre Lengyel
Publikováno v:
Cells, 12(5):773. Multidisciplinary Digital Publishing Institute (MDPI)
Emri, E, Cappa, O, Kelly, C, Kortvely, E, SanGiovanni, J P, McKay, B S, Bergen, A A, Simpson, D A & Lengyel, I 2023, ' Zinc supplementation induced transcriptional changes in primary human retinal pigment epithelium: a single-cell RNA sequencing study to understand age-related macular degeneration ', Cells, vol. 12, no. 5, 773 . https://doi.org/10.3390/cells12050773
Cells
Volume 12
Issue 5
Pages: 773
Emri, E, Cappa, O, Kelly, C, Kortvely, E, SanGiovanni, J P, McKay, B S, Bergen, A A, Simpson, D A & Lengyel, I 2023, ' Zinc supplementation induced transcriptional changes in primary human retinal pigment epithelium: a single-cell RNA sequencing study to understand age-related macular degeneration ', Cells, vol. 12, no. 5, 773 . https://doi.org/10.3390/cells12050773
Cells
Volume 12
Issue 5
Pages: 773
Zinc supplementation had been shown to be beneficial to slow the progression of age-related macular degeneration (AMD). However, the molecular mechanism underpinning this benefit is not well understood. In this study, we used single-cell RNA sequenci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed4012bab0e44ffd4deccb7b05a9cfc
https://doi.org/10.1101/2022.09.01.504514
https://doi.org/10.1101/2022.09.01.504514