Zobrazeno 1 - 10
of 170
pro vyhledávání: '"John Paul Pezacki"'
Publikováno v:
ACS Omega, Vol 9, Iss 24, Pp 26428-26438 (2024)
Externí odkaz:
https://doaj.org/article/66850d0d7fda47bb847599098bd63450
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Endonucleases are enzymes that cleave internal phosphodiester bonds within double-stranded DNA or RNA and are essential for biological functions. Herein, we use genetic code expansion to create an unnatural endonuclease that cleaves non-codi
Externí odkaz:
https://doaj.org/article/b68cd8048be743b6807de9920303bf36
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/5b27edf6a08141f5a7e93216f5685eac
Publikováno v:
Viruses, Vol 15, Iss 9, p 1921 (2023)
With the emergence of the novel betacoronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), there has been an urgent need for the development of fast-acting antivirals, particularly in dealing with different variants of concern (VOC
Externí odkaz:
https://doaj.org/article/b04788f8017046adb65dc54a7b48e912
Publikováno v:
FEBS Open Bio, Vol 9, Iss 6, Pp 1042-1051 (2019)
Viral suppressors of RNA silencing (VSRSs) are a diverse group of viral proteins that have evolved to disrupt eukaryotic RNA silencing pathways, thereby contributing to viral pathogenicity. The p19 protein is a VSRS that selectively binds to short in
Externí odkaz:
https://doaj.org/article/5e8d095a74aa4108b2c233abd8dbfd4e
Publikováno v:
ACS Omega, Vol 3, Iss 12, Pp 17227-17235 (2018)
Externí odkaz:
https://doaj.org/article/50ea571453ec4721bd0052843672fb49
Autor:
Tyler A. Shaw, Ragunath Singaravelu, Megan H. Powdrill, Jordan Nhan, Nadine Ahmed, Dennis Özcelik, John Paul Pezacki
Publikováno v:
iScience, Vol 10, Iss , Pp 149-157 (2018)
Summary: MicroRNAs (miRNAs) are part of a complex regulatory network that modulates cellular lipid metabolism. Here, we identify miR-124 as a regulator of triglyceride (TG) metabolism. This study advances our knowledge of the role of miR-124 in human
Externí odkaz:
https://doaj.org/article/dc36f477afbf46ada4b1a32be24a9813
Autor:
Mariya Chigrinova, Douglas A. MacKenzie, Allison R. Sherratt, Lawrence L. W. Cheung, John Paul Pezacki
Publikováno v:
Molecules, Vol 20, Iss 4, Pp 6959-6969 (2015)
The Kinugasa reaction has become an efficient method for the direct synthesis of β-lactams from substituted nitrones and copper(I) acetylides. In recent years, the reaction scope has been expanded to include the use of water as the solvent, and with
Externí odkaz:
https://doaj.org/article/9a8b35e2b33c48638f6b5ec2d69615e7
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
RNA interference (RNAi) is the biological mechanism that allows targeted gene knockdown through the addition of exogenous short-interfering RNAs (siRNAs) to cells and organisms. RNAi has revolutionized cell biology and holds enormous potential for hu
Externí odkaz:
https://doaj.org/article/7e0f9e4ec1e44366ae8a827d1ffec5d5
Autor:
Nirmal Mazumder, Rodney K Lyn, Ragunath Singaravelu, Andrew Ridsdale, Douglas J Moffatt, Chih-Wei Hu, Han-Ruei Tsai, John McLauchlan, Albert Stolow, Fu-Jen Kao, John Paul Pezacki
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66738 (2013)
Hepatitis C virus (HCV) co-opts hepatic lipid pathways to facilitate its pathogenesis. The virus alters cellular lipid biosynthesis and trafficking, and causes an accumulation of lipid droplets (LDs) that gives rise to hepatic steatosis. Little is kn
Externí odkaz:
https://doaj.org/article/f66f39a8d49b402983602a5bd2d119ab