Zobrazeno 1 - 10
of 259
pro vyhledávání: '"John Patrick Aggleton"'
Autor:
John Patrick Aggleton, Claudia Metzler-Baddeley, Rebecca Sims, Seralynne Denise Vann, Parisa A. Ghomroudi, Bethany M. Coad
Publikováno v:
Neurobiology of Aging. 113:39-54
Characterizing age- and risk-related hippocampal vulnerabilities may inform about the neural underpinnings of cognitive decline. We studied the impact of three risk-factors, Apolipoprotein (APOE)-ε4, a family history of dementia, and central obesity
Autor:
Mark Postans, John Patrick Aggleton, Thomas M. Lancaster, Chiara M Casella, Andrew D. Lawrence, Samuel C. Berry
Invasive tract-tracing studies in rodents implicate a direct connection between the subiculum and bed nucleus of the stria terminalis (BNST) as a key component of neural pathways mediating hippocampal regulation of the Hypothalamic-Pituitary-Adrenal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc0f1580a4c4edfae945132616a51a9
https://orca.cardiff.ac.uk/id/eprint/148388/2/1-s2.0-S1053811922002245-main.pdf
https://orca.cardiff.ac.uk/id/eprint/148388/2/1-s2.0-S1053811922002245-main.pdf
Autor:
John Patrick Aggleton, Emma Jane Kidd, Jilu P. Mole, John Evans, Claudia Metzler-Baddeley, Fabrizio Fasano, Rebecca Sims
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-25 (2020)
Scientific Reports
Scientific Reports
APOE-ε4 is a main genetic risk factor for developing late onset Alzheimer’s disease (LOAD) and is thought to interact adversely with other risk factors on the brain. However, evidence regarding the impact of APOE-ε4 on grey matter structure in as
Publikováno v:
The Journal of Neuroscience
The hippocampus is essential for normal memory but does not act in isolation. The anterior thalamic nuclei may represent one vital partner. Using DREADDs, the behavioral consequences of transiently disrupting anterior thalamic function were examined,
Autor:
John Evans, Jilu P. Mole, Derek K. Jones, Fabrizio Fasano, Claudia Metzler-Baddeley, Roland J. Baddeley, Rebecca Sims, John Patrick Aggleton
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-4 (2019)
Scientific Reports
Scientific Reports
Aging leads to gray and white matter decline but their causation remains unclear. We explored two classes of models of age and dementia risk related brain changes. The first class of models emphasises the importance of gray matter: age and risk-relat
Retrosplenial cortex contains two principal subdivisions, area 29 (granular) and area 30 (dysgranular). Their respective anatomical connections in the rat brain reveal that area 29 is the primary recipient of hippocampal and parahippocampal spatial a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc12cc3e06dc8325d1f97a14fb60eb39
Autor:
Matheus Cafalchio, Sean K. Martin, Bethany E. Frost, John Patrick Aggleton, Nurul Islam, Shane M. O'Mara
Publikováno v:
The Journal of Neuroscience
Just as hippocampal lesions are principally responsible for “temporal lobe” amnesia, lesions affecting the anterior thalamic nuclei seem principally responsible for a similar loss of memory, “diencephalic” amnesia. Compared with the former, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b42205512ddfe42e9e163dd051a7fc
https://orca.cardiff.ac.uk/id/eprint/140365/2/JNEUROSCI.2868-20.2021.full.pdf
https://orca.cardiff.ac.uk/id/eprint/140365/2/JNEUROSCI.2868-20.2021.full.pdf
Autor:
John Patrick Aggleton, Anna S. Mitchell, Han Y. Cheng, Mathias L. Mathiasen, Ningyu Zhang, Kate J. Jeffery, Eleonora Lomi
Retrosplenial cortex (RSC) lies at the interface between perceptual and memory networks in the brain and mediates between these, although it is not yet known how. It has two distinct subregions, granular (gRSC) and dysgranular (dRSC). The present stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f9f0c431ae1f0f8525f6308f93199b
https://doi.org/10.1101/2021.06.11.448056
https://doi.org/10.1101/2021.06.11.448056
Autor:
Andrew John Dudley Nelson, Anna Louise Powell, Joshua David Holmes, Seralynne Denise Vann, John Patrick Aggleton
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 9 (2015)
The retrosplenial cortex supports navigation, but there are good reasons to suppose that the retrosplenial cortex has a very different role in spatial memory from that of the hippocampus and anterior thalamic nuclei. For example, retrosplenial lesion
Externí odkaz:
https://doaj.org/article/2bd20b5a2c784f599d5cb97da10d1d21
Autor:
Andrew John Dudley Nelson, Emma Logan Hindley, John Martindale Pearce, Seralynne Denise Vann, John Patrick Aggleton
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 9 (2015)
The study examined the importance of the retrosplenial cortex for the incidental learning of the spatial arrangement of distinctive features within a scene. In a modified Morris water-maze, rats spontaneously learnt the location of an escape platform
Externí odkaz:
https://doaj.org/article/5c6c13767e064ac399a2de4688b72a7b