Zobrazeno 1 - 10
of 332
pro vyhledávání: '"John Papaconstantinou"'
Autor:
John Papaconstantinou
Publikováno v:
Cells, Vol 8, Iss 11, p 1383 (2019)
The ASK1-signalosome→p38 MAPK and SAPK/JNK signaling networks promote senescence (in vitro) and aging (in vivo, animal models and human cohorts) in response to oxidative stress and inflammation. These networks contribute to the promotion of age-ass
Externí odkaz:
https://doaj.org/article/6570fcdbe94641879a221e816fa67346
Autor:
Samantha Sheller, John Papaconstantinou, Rheanna Urrabaz-Garza, Lauren Richardson, George Saade, Carlos Salomon, Ramkumar Menon
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157614 (2016)
At term, the signals of fetal maturity and feto-placental tissue aging prompt uterine readiness for delivery by transitioning quiescent myometrium to an active stage. It is still unclear how the signals reach the distant myometrium. Exosomes are a sp
Externí odkaz:
https://doaj.org/article/72d95915c87e499b9f9fa12e41bdd68a
Autor:
Reynolds K Brobey, Dwight German, Patricia K Sonsalla, Prem Gurnani, Johanne Pastor, C-C Hsieh, John Papaconstantinou, Philip P Foster, Makoto Kuro-o, Kevin P Rosenblatt
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139914 (2015)
Klotho transgenic mice exhibit resistance to oxidative stress as measured by their urinal levels of 8-hydroxy-2-deoxyguanosine, albeit this anti-oxidant defense mechanism has not been locally investigated in the brain. Here, we tested the hypothesis
Externí odkaz:
https://doaj.org/article/2d036155ea0c407e9de22a09770a55f3
Autor:
Sarah Bredeson, John Papaconstantinou, James H Deford, Talar Kechichian, Tariq A Syed, George R Saade, Ramkumar Menon
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113799 (2014)
OBJECTIVE: Spontaneous preterm birth (PTB) and preterm prelabor rupture of membranes (pPROM) are major pregnancy complications often associated with a fetal inflammatory response. Biomolecular markers of this fetal inflammatory response to both infec
Externí odkaz:
https://doaj.org/article/76e86f6ff29c40b6bd2afd15abe6b820
Autor:
Ramkumar Menon, Istvan Boldogh, Rheanna Urrabaz-Garza, Jossimara Polettini, Tariq Ali Syed, George R Saade, John Papaconstantinou, Robert N Taylor
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83416 (2013)
Oxidative stress is a postulated etiology of spontaneous preterm birth (PTB) and preterm prelabor rupture of the membranes (pPROM); however, the precise mechanistic role of reactive oxygen species (ROS) in these complications is unclear. The objectiv
Externí odkaz:
https://doaj.org/article/739a0455358149379c6a9b65aaefc736
Autor:
John Papaconstantinou
Publikováno v:
Journal of Skeletal Muscle. 1:27-54
Aging mammalian skeletal muscle satellite cells (MuSCs) undergo a decline of stem cell/progenitor cell proliferative and regenerative capacity, and the development of a physiological milieu characteristic of a state of chronic sterile inflammation. p
Autor:
Christopher S. Fry, Stanley J. Watowich, Camille R. Brightwell, Stanton F. McHardy, Ted G. Graber, Hua Yu Leo Wang, Rosario Maroto, Harshini Neelakantan, John Papaconstantinou
Publikováno v:
Biochem Pharmacol
Aging is accompanied by progressive declines in skeletal muscle mass and strength and impaired regenerative capacity, predisposing older adults to debilitating age-related muscle deteriorations and severe morbidity. Muscle stem cells (muSCs) that pro
INTRODUCTION: Cytoreductive surgery (CRS) with hyperthermal intraperitoneal chemotherapy (HIPEC) are established treatments for peritoneal carcinomatosis that prolong survival in carefully selected patients. At the time of diagnosis, 4-7% of patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::477e986eec69d1a895d110556205b62d
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3188771
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3188771
Autor:
Naseem H. Ansari, James H. DeFord, Chen Z. Wang, Dmitry V. Bulavin, Min Zhang, San Yang, John Papaconstantinou
Publikováno v:
Aging (Albany NY)
Functional competence and self-renewal of mammalian skeletal muscle myofibers and progenitor cells declines with age. Progression of the muscle aging phenotype involves the decline of juvenile protective factorsi.e., proteins whose beneficial functio
Publikováno v:
Encyclopedia of Signaling Molecules ISBN: 9781461464389
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d9db8e19af4c4f6819f90c29845485
https://doi.org/10.1007/978-1-4614-6438-9_221-1
https://doi.org/10.1007/978-1-4614-6438-9_221-1