Zobrazeno 1 - 4
of 4
pro vyhledávání: '"John Palucki"'
Autor:
Laura DeVault, Chase Mateusiak, John Palucki, Michael Brent, Jeffrey Milbrandt, Aaron DiAntonio
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0300539 (2024)
Genetic and pharmacological perturbation of the cytoskeleton enhances the regenerative potential of neurons. This response requires Dual-leucine Zipper Kinase (DLK), a neuronal stress sensor that is a central regulator of axon regeneration and degene
Externí odkaz:
https://doaj.org/article/43b39fdcbbcd4e89a6be7c2cf9545dfb
Autor:
E J Brace, Kow Essuman, Xianrong Mao, John Palucki, Yo Sasaki, Jeff Milbrandt, Aaron DiAntonio
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010246 (2022)
SARM1 is the founding member of the TIR-domain family of NAD+ hydrolases and the central executioner of pathological axon degeneration. SARM1-dependent degeneration requires NAD+ hydrolysis. Prior to the discovery that SARM1 is an enzyme, SARM1 was s
Externí odkaz:
https://doaj.org/article/87f9821d636d4fa39f09839fe6ebf516
Autor:
E. J. Brace, Kow Essuman, Xianrong Mao, John Palucki, Yo Sasaki, Jeff Milbrandt, Aaron DiAntonio
Publikováno v:
PLoS genetics. 18(6)
SARM1 is the founding member of the TIR-domain family of NAD+hydrolases and the central executioner of pathological axon degeneration. SARM1-dependent degeneration requires NAD+hydrolysis. Prior to the discovery that SARM1 is an enzyme, SARM1 was stu
Autor:
John Palucki, Mukesh Sharma, Yanchun Pan, Hiroko Yano, Albert H. Kim, Shaopeng Liu, Ying Zhu, Yo Sasaki, Eric Tycksen, Wei Yang, Linjian Zhu, Bo Zhang
Publikováno v:
Journal of Biological Chemistry. 293:11850-11866
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an abnormal expansion of polyglutamine repeats in the huntingtin protein (Htt). Transcriptional dysregulation is an early event in the course of HD progression and is thought t