Zobrazeno 1 - 10
of 63
pro vyhledávání: '"John P. Stone"'
Autor:
Annemarie Weissenbacher, John P. Stone, Maria Letizia Lo Faro, James P. Hunter, Rutger J. Ploeg, Constantin C. Coussios, James E. Fildes, Peter J. Friend
Publikováno v:
Frontiers in Medicine, Vol 8 (2022)
Kidney transplantation is the best renal-replacement option for most patients with end-stage renal disease. Normothermic machine preservation (NMP) of the kidney has been studied extensively during the last two decades and implemented in clinical tri
Externí odkaz:
https://doaj.org/article/89bd6f784cbf4429b5cd60f1962ee65f
Autor:
William R. Critchley, John P. Stone, Qiuming Liao, Guangqi Qin, Ivar Risnes, Andrew Trafford, Helge Scott, Trygve Sjöberg, Stig Steen, James E. Fildes
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Introduction: Many donor organs contain significant leukocyte reservoirs which upon transplantation activate recipient leukocytes to initiate acute rejection. We aimed to assess whether non-ischemic heart preservation via ex vivo perfusion promotes i
Externí odkaz:
https://doaj.org/article/6b325d67fdef4f73af1a01f9bfa6e2e8
Autor:
John P. Stone, Alexandra L. Ball, William R. Critchley, Triin Major, Rebecca J. Edge, Kavit Amin, Marc J. Clancy, James E. Fildes
Publikováno v:
Kidney International Reports, Vol 1, Iss 4, Pp 230-239 (2016)
Ex vivo normothermic perfusion offers an alternative method of organ preservation, allowing donor kidneys to be reanimated and evaluated prior to transplantation. Beyond preservation, it can be used to characterize the immunological contribution of t
Externí odkaz:
https://doaj.org/article/0d5fb2fcfd27470e9ab4b6357a30ce33
Autor:
Elwasif, Wael, Godoy, William, Hagerty, Nick, Harris, J. Austin, Hernandez, Oscar, Joo, Balint, Kent, Paul, Lebrun-Grandie, Damien, Maccarthy, Elijah, Vergara, Veronica G. Melesse, Messer, Bronson, Miller, Ross, Opal, Sarp, Bastrakov, Sergei, Bussmann, Michael, Debus, Alexander, Steinger, Klaus, Stephan, Jan, Widera, Rene, Bryngelson, Spencer H., Berre, Henry Le, Radhakrishnan, Anand, Young, Jefferey, Chandrasekaran, Sunita, Ciorba, Florina, Simsek, Osman, Spiga, Kate Clark Filippo, Hammond, Jeff, Hardy, John E. Stone. David, Keller, Sebastian, Trott, Jean-Guillaume Piccinali. Christian
Publikováno v:
Proceedings of the HPC Asia 2023 Workshops, pg 35-49
This paper assesses and reports the experience of ten teams working to port,validate, and benchmark several High Performance Computing applications on a novel GPU-accelerated Arm testbed system. The testbed consists of eight NVIDIA Arm HPC Developer
Externí odkaz:
http://arxiv.org/abs/2209.09731
Autor:
Cory Perugino, Emma L. Culver, Arezou Khosroshahi, Wen Zhang, Emanuel Della-Torre, Kazuichi Okazaki, Yoshiya Tanaka, Matthias Löhr, Nicolas Schleinitz, Judith Falloon, Dewei She, Daniel Cimbora, John H. Stone
Publikováno v:
Rheumatology and Therapy, Vol 10, Iss 6, Pp 1795-1808 (2023)
Abstract Introduction Immunoglobulin G4-related disease (IgG4-RD) is a debilitating multiorgan disease characterized by recurring flares leading to organ dysfunction, decreased quality of life, and mortality. Glucocorticoids, the standard of care for
Externí odkaz:
https://doaj.org/article/8fd489c2c4564ecf821166afa716dc2e
Autor:
Wolfgang A. Schmidt, Bhaskar Dasgupta, Jennifer Sloane, Angeliki Giannelou, Yuqing Xu, Sebastian H. Unizony, Sarah L. Mackie, Miguel A. Gonzalez-Gay, Robert Spiera, Kenneth J. Warrington, Peter M. Villiger, Michael C. Nivens, Bolanle Akinlade, Yong Lin, Frank Buttgereit, John H. Stone
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-16 (2023)
Abstract Background Giant cell arteritis (GCA) is primarily treated with glucocorticoids (GCs), which have substantial toxicity. Tocilizumab, an interleukin-6-receptor inhibitor (IL-6Ri), showed beneficial effects in GCA, leading to its approval. Thi
Externí odkaz:
https://doaj.org/article/4519641ec60d4627b6d5c6d36c1bb6ac
Publikováno v:
ACR Open Rheumatology, Vol 5, Iss 1, Pp 51-58 (2023)
Objective Giant cell arteritis (GCA) requires treatment with high‐dose, long‐term glucocorticoids (GCs). A score assessing and quantifying patients’ baseline GC‐related toxicity may be important to risk stratification and therapeutic decision
Externí odkaz:
https://doaj.org/article/a4124a5235a34d4d87da404f7063ae42
Autor:
Rory L. Cochran, MD, PhD, Holly R. Brideau, MD, MS, Markus Y. Wu, MD, John H. Stone, MD, MPH, Zachary S. Wallace, MD, MSc, Brent P. Little, MD
Publikováno v:
Radiology Case Reports, Vol 17, Iss 12, Pp 4924-4927 (2022)
IgG4-related disease (IgG4-RD) is an immune-mediated multiorgan fibroinflammatory disorder with variable clinical presentations. IgG4-RD cardiovascular involvement is considered rare, with pulmonary arterial involvement reported in a small subset of
Externí odkaz:
https://doaj.org/article/6580416c09244247bf569df4ab3f31ad
Autor:
Naoki Kaneko, Hu Chen, Cory A. Perugino, Takashi Maehara, Ryusuke Munemura, Shiho Yokomizo, Junsei Sameshima, Thomas J. Diefenbach, Katherine R. Premo, Akira Chinju, Yuka Miyahara, Mizuki Sakamoto, Masafumi Moriyama, John H. Stone, Seiji Nakamura, Shiv Pillai
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Sjögren’s syndrome is a chronic autoimmune disorder whose pathogenesis is poorly understood and that lacks effective therapies. Detailed quantitative and spatial analyses of tissues affected by Sjögren’s syndrome were undertaken, inclu
Externí odkaz:
https://doaj.org/article/6813e2fa2bbf4c22b51356c495070222
Autor:
Benjamin R. Gilbert, Zane R. Thornburg, Troy A. Brier, Jan A. Stevens, Fabian Grünewald, John E. Stone, Siewert J. Marrink, Zaida Luthey-Schulten
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Computational models of cells cannot be considered complete unless they include the most fundamental process of life, the replication and inheritance of genetic material. By creating a computational framework to model systems of replicating bacterial
Externí odkaz:
https://doaj.org/article/42b2539a78d14ebabeca3d47e234ce28