Zobrazeno 1 - 10 of 17 pro vyhledávání: '"John P. Sotolongo"'
1
Human Intestinal Epithelial Cells Express Interleukin-10 through Toll-Like Receptor 4-Mediated Epithelial-Macrophage Crosstalk
Autor: Jose Ruiz, Pedro Salas, Stephan R. Targan, John P. Sotolongo, Jinhee Hyun, Ana Laura Alonso, Reldy Riveron, Claudia Flores, Saravana Kanagavelu, Masayuki Fukata, Sally Chun, Gaurav Singh, Kristina D. Chung, Laura Romero, Armine Manukyan
Publikováno v: Journal of Innate Immunity. 7:87-101
In the intestine, interaction between epithelial cells and macrophages (MΦs) create a unique immunoregulatory microenvironment necessary to maintain local immune and tissue homeostasis. Human intestinal epithelial cells (IECs) have been shown to exp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86a12831743a0b28d4267c65dce08274
https://doi.org/10.1159/000365417
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2
Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity
Autor: Kurt Schesser, Rebeca Santaolalla, David Siefker, Masayuki Fukata, Andrea Echeverry, John P. Sotolongo, Becky Adkins, Julia Zaias, Norman H. Altman, Jose Ruiz, Cecilia Espana
Publikováno v: The Journal of Experimental Medicine
TRIF signaling triggers the amplification of macrophage bactericidal activity sufficient to eliminate invading intestinal pathogens through the sequential induction of IFN-β and IFN-γ from macrophages and NK cells, respectively.
Toll-like rece
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c4632b72d9390c96489969ab7f6fe2
http://europepmc.org/articles/PMC3244044
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3
A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis
Autor: John P. Sotolongo, Yasmín Hernández, David Hsu, Ruliang Xu, Marie Kosco-Vilbois, Maria T. Abreu, Lloyd Mayer, Julia Zaias, Greg Elson, Ryan C. Ungaro, Masayuki Fukata, Keith J. Breglio, Cecillia Espana, Anli Chen
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G1167-G1179
Dysregulated innate immune responses to commensal bacteria contribute to the development of inflammatory bowel disease (IBD). TLR4 is overexpressed in the intestinal mucosa of IBD patients and may contribute to uncontrolled inflammation. However, TLR
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7b384b8519d84b242d5bbc5807b157
https://doi.org/10.1152/ajpgi.90496.2008
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4
TRIF mobilizes unique primary defense against Gram-negative bacteria in intestinal interface
Autor: John P. Sotolongo, Masayuki Fukata, Saravana Kanagavelu, Jose Ruiz, Jinhee Hyun
Publikováno v: Gut microbes. 3(5)
The gastrointestinal tract is the largest mucosal surface in our body. It houses diverse microorganisms that collectively form the commensal microbial community. The security of this community is kept by host-microbial interactions and is violated by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe13fa3edb1d1fb053d84cad2f46e25
https://pubmed.ncbi.nlm.nih.gov/22713267
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5
The role of innate immunity in the host defense against intestinal bacterial pathogens
Autor: Jose Ruiz, Masayuki Fukata, John P. Sotolongo
Publikováno v: Current infectious disease reports. 14(1)
Eradication of infectious disease is our global health challenge. After encountering intestinal infection with a bacterial pathogen, the host defense program is initiated by local antigen-presenting cells (APCs) that eliminate invading pathogens by p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356cea06206b3e91fcda9647f6f63a4a
https://pubmed.ncbi.nlm.nih.gov/22139594
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6
Toll-like receptor 4 signaling integrates intestinal inflammation with tumorigenesis: lessons from the murine model of colitis-associated cancer
Autor: John P. Sotolongo, Yasmin Hernandez, Masayuki Fukata
Publikováno v: Cancers
Cancers, Vol 3, Iss 3, Pp 3104-3113 (2011)
Chronic inflammation has long been implicated as a predisposition for cancer, but the underlying mechanism for how this occurs has remained obscure. Ulcerative colitis (UC) is a chronic inflammatory disorder of the large intestine which is known to b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea064044d5d26a1a721b3835d90add78
https://pubmed.ncbi.nlm.nih.gov/24212947
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8
The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia
Autor: Cristhine Pastorini, Anli Chen, Daisy E. Conduah, Keith J. Breglio, Maria T. Abreu, Ruliang Xu, John P. Sotolongo, David Hsu, Lory Hayes, Yasmín Hernández, Ryan C. Ungaro, Masayuki Fukata
Publikováno v: BMC Gastroenterology, Vol 10, Iss 1, p 82 (2010)
BMC Gastroenterology
BackgroundWe have previously found that TLR4-deficient (TLR4-/-) mice demonstrate decreased expression of mucosal PGE2and are protected against colitis-associated neoplasia. However, it is still unclear whether PGE2is the central factor downstream of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3913037a1c9b2aa3b19da265e4ddc27
https://doi.org/10.1186/1471-230x-10-82
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9
Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury
Autor: Maria T. Abreu, Yasmín Hernández, Lory Hayes, Ruliang Xu, Anli Chen, Junsuke Maki, John P. Sotolongo, Tyralee Goo, Ryan C. Ungaro, Keith J. Breglio, Masayuki Fukata, David Hsu
Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 90(9)
Epiregulin (EPI) and amphiregulin (AR) are epidermal growth factor receptor (EGFR) ligands implicated in mucosal repair and tumorigenesis. We have shown that Toll-like receptor 4 (TLR4) induces intestinal epithelial cell (IEC) proliferation by activa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9d66dc127246b5d7a9160b2c22d0fc
https://pubmed.ncbi.nlm.nih.gov/20498653
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10
TLR4 Activates the β-catenin Pathway to Cause Intestinal Neoplasia
Autor: Maria T. Abreu, Jeffrey Z. Ko, Daniel A. Sussman, Julie M. Davies, Oname Burlingame, Pablo A. Bejarano, Limin Shang, Mansoor M. Ahmed, Jose R. Ruiz, John P. Sotolongo, Sergio A. Lira, Rebeca Santaolalla, Sakhi Philip, Terrence A. Barrett, Cecilia Espana, Ramanarao Dirisina, Masayuki Fukata, Cristhine Pastorini
Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63298 (2013)
PLoS ONE
Colonic bacteria have been implicated in the development of colon cancer. We have previously demonstrated that toll-like receptor 4 (TLR4), the receptor for bacterial lipopolysaccharide (LPS), is over-expressed in humans with colitis-associated cance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d3309f1384d0a004420a8c3d14b82e
https://doi.org/10.1371/journal.pone.0063298
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