Zobrazeno 1 - 7
of 7
pro vyhledávání: '"John P. Schafer"'
Autor:
Richard D. Spencer, Michael E. Kopach, Martin D. Johnson, John P. Schafer, Michael R. Heller, Jennifer McClary Groh, Jonathan J. Adler, Timothy M. Braden, Jeffrey Lewis
Publikováno v:
Organic Process Research & Development. 21:317-326
A flow Barbier process was developed to produce a key intermediate in the edivoxetine·HCl registered sequence. The control strategy was developed based on a critical understanding of integrated parameters and design space requirements for a continuo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6d4aab6a7e5757fbfdf202865e09d1c
https://doi.org/10.1021/acs.oprd.6b00373
https://doi.org/10.1021/acs.oprd.6b00373
Autor:
Jennifer McClary Groh, Kevin P. Cole, Patrick M. Pollock, Michael E. Kopach, Martin D. Johnson, Timothy M. Braden, Luke P. Webster, John P. Schafer, Adam D. McFarland, Jonathan J. Adler, Morgan Rosemeyer
Publikováno v:
Organic Process Research & Development. 20:1581-1592
Efficient continuous Grignard and lithiation processes were developed to produce one of the key regulatory starting materials for the production of edivoxetine hydrochoride. For the Grignard process, organometallic reagent formation, Bouveault formyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd83849961f6569edb3ef9299f4c313
https://doi.org/10.1021/acs.oprd.6b00131
https://doi.org/10.1021/acs.oprd.6b00131
Autor:
Michael E. LeTourneau, Gregory A. Stephenson, Bruce E. Parker, Lisa M. H. Zollars, Jason S. Cronin, Nicholas A. Magnus, James Abraham Aikins, John P. Schafer, Susan M. Reutzel-Edens, and Shella L. Tameze, Michael A. Staszak, Amy D. Hargis, William D. Diseroad
Publikováno v:
Organic Process Research & Development. 9:621-628
This article describes the development and optimization of chemical reactions and subsequent preparation of the API LY503430 under cGMPs to fund first human dose (FHD) clinical evaluation as a potential therapeutic agent for Parkinson's disease. Reas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d221a6e2a65d84e6e8be32a0a3d52af0
https://doi.org/10.1021/op0500741
https://doi.org/10.1021/op0500741
Autor:
Elizabeth Haley London, John P. Schafer, Woodrow B. Thompson, M. L. DiGiacomo-Cohen, R.S. Lewis, Janet Radway Stone
Publikováno v:
Scientific Investigations Map.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3656668c8be70706c2fa37a8fc5c3ed
https://doi.org/10.3133/sim2784
https://doi.org/10.3133/sim2784
Autor:
Janet Radway Stone, Elizabeth Haley London, Woodrow B. Thompson, M. L. DiGiacomo-Cohen, John P. Schafer, R.S. Lewis
Publikováno v:
Open-File Report.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18c89e9cdf28dd1c2f511536eca84e76
https://doi.org/10.3133/ofr98371
https://doi.org/10.3133/ofr98371
Autor:
John P. Schafer, Jennifer McClary Groh, Dilwyn J. Roberts, Michael E. Kopach, Kobierski Michael Edward, Martin D. Johnson, Jonathan J. Adler, William G. Trankle
Publikováno v:
Green Chemistry. 14:1524
A key pharmaceutical intermediate (1) for production of edivoxetine·HCl was prepared in >99% ee via a continuous Barbier reaction, which improves the greenness of the process relative to a traditional Grignard batch process. The Barbier flow process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4711d03a3cfa69dd1f778faac0ca62
https://doi.org/10.1039/c2gc35050e
https://doi.org/10.1039/c2gc35050e
Publikováno v:
Open-File Report.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f22d0b4f013668af648a003543778bc
https://doi.org/10.3133/ofr85266
https://doi.org/10.3133/ofr85266