Zobrazeno 1 - 10
of 27
pro vyhledávání: '"John P. Savaryn"'
Autor:
John P. Savaryn, Richard L. Smith, Matthew Rosebraugh, Melina Neenan, Richard Burton, Kennan Marsh, David Wagner
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 2, Pp n/a-n/a (2024)
Abstract Analysis was conducted to compare levodopa/carbidopa pharmacokinetics and drug‐related material in plasma of healthy participants after receiving a continuous infusion of Levodopa/Carbidopa Intestinal Gel (LCIG) to a continuous subcutaneou
Externí odkaz:
https://doaj.org/article/905647f03fa242e5850562a33da60601
Autor:
Peer B. Jacobson, Robin Goody, Matthew Lawrence, Bernhard K. Mueller, Xiaomeng Zhang, Bradley A. Hooker, Kimberly Pfleeger, Adam Ziemann, Charles Locke, Quentin Barraud, Mathias Droescher, Joerg Bernhard, Andreas Popp, Preethne Boeser, Lili Huang, Jennifer Mollon, Yulia Mordashova, Yi-Fang Cui, John P. Savaryn, Christine Grinnell, Ingeborg Dreher, Michael Gold, Grégoire Courtine, Andrea Mothe, Charles H. Tator, James D. Guest
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105385- (2021)
Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and myelin loss. Spontaneous recovery is limited, and there are no approved pharmaceutical treat
Externí odkaz:
https://doaj.org/article/8dc4097a8c454ae6bfbbc5ad5984d8ca
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269157 (2022)
Tau protein is a key target of interest in developing therapeutics for neurodegenerative diseases. Here, we sought to develop a method that quantifies extracellular tau protein concentrations in human cerebrospinal fluid (CSF) without antibody-based
Externí odkaz:
https://doaj.org/article/50a4e3e212e143dd8ace87036d009ac9
Publikováno v:
Drug Metabolism and Disposition. 50:105-113
Screening for cytochrome P450 (CYP) induction potential is routine in drug development. Induction results in a net increase in CYP protein and is assessed typically by measuring indirect endpoints, i.e., enzyme activity and mRNA in vitro. Recent meth
Publikováno v:
Rapid communications in mass spectrometry : RCMREFERENCES. 36(22)
The in-sample calibration curve (ISCC) approach of quantification utilizes the response of isotopologue ions from spiked-in stable isotope labeled internal standard (SIL-IS) to build a standard curve. The quantitative analysis of the study sample is
Publikováno v:
Bioanalysis. 14(5)
Background: Currently, no regulatory guidelines are available for parallelism assessment for LC-MS biomarker quantification. Spike recovery, standard addition and dilutional linearity are recommended with no mention of the implications of applying th
Autor:
Sami Osman, Christian Goess, Xiazi Qiu, David B. Duignan, Qin C. Ji, John P. Savaryn, Gary J. Jenkins
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1180
LC/MS quantification of leukotoxin (LTX) and leukotoxin diol (LTXdiol) in plasma has been previously reported, however large sample volumes are required for achieving stated assay Lower Limit of Quantification (LLOQ). Reported here is a fit-for-purpo
Autor:
Ryota Kikuchi, Sonia M. de Morais, Gary J. Jenkins, Kenneth R. Durbin, Junli Ma, William J. Chiou, Daniel A.J. Bow, John P. Savaryn, Arian Emami Riedmaier
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 49(10)
The successful prospective incorporation of in vitro transporter kinetics in physiologically based pharmacokinetic (PBPK) models to describe drug disposition remains challenging. Although determination of scaling factors to extrapolate in vitro to in
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(7)
Despite the availability of liquid chromatography (LC)-mass spectrometry (MS) methods for quantifying cytochrome P450 (P450) proteins, incorporation of P450 protein quantification into induction study workflows has not been widely adopted. To more re