Zobrazeno 1 - 10
of 36
pro vyhledávání: '"John P. Murad"'
Autor:
Eric Hee Jun Lee, John P. Murad, Lea Christian, Jackson Gibson, Yukiko Yamaguchi, Cody Cullen, Diana Gumber, Anthony K. Park, Cari Young, Isabel Monroy, Jason Yang, Lawrence A. Stern, Lauren N. Adkins, Gaurav Dhapola, Brenna Gittins, Wen-Chung Chang, Catalina Martinez, Yanghee Woo, Mihaela Cristea, Lorna Rodriguez-Rodriguez, Jun Ishihara, John K. Lee, Stephen J. Forman, Leo D. Wang, Saul J. Priceman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Chimeric antigen receptor (CAR) T cell therapeutic responses are hampered by limited T cell trafficking, persistence, and durable anti-tumor activity in solid tumors. However, these challenges can be largely overcome by relatively unconstrai
Externí odkaz:
https://doaj.org/article/211ce127e82c40c7b1c8f149a15dcd09
Autor:
Brile Chung, Ali A. Esmaeili, Sailesh Gopalakrishna-Pillai, John P. Murad, Emily S. Andersen, Naveen Kumar Reddy, Gayathri Srinivasan, Brian Armstrong, Caleb Chu, Young Kim, Tommy Tong, James Waisman, John H. Yim, Behnam Badie, Peter P. Lee
Publikováno v:
npj Breast Cancer, Vol 3, Iss 1, Pp 1-9 (2017)
Metastasis: brain metastases fuel further spread Breast cancer metastases to the brain secrete signaling molecules that promote additional cancer cells to migrate there. Peter P. Lee and colleagues from the City of Hope in Duarte, California, USA, an
Externí odkaz:
https://doaj.org/article/88e4e0bed8d344088500b4cc7cf40aed
Autor:
John P. Murad, Anna K. Kozlowska, Hee Jun Lee, Maya Ramamurthy, Wen-Chung Chang, Paul Yazaki, David Colcher, John Shively, Mihaela Cristea, Stephen J. Forman, Saul J. Priceman
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Impressive clinical efficacy of chimeric antigen receptor (CAR)-engineered T cell therapy for hematological malignancies have prompted significant efforts in achieving similar responses in solid tumors. The lack of truly restricted and uniform expres
Externí odkaz:
https://doaj.org/article/03ff7a9430ab4c70be8c4bbe6027d5ef
Autor:
Saul J. Priceman, Ethan A. Gerdts, Dileshni Tilakawardane, Kelly T. Kennewick, John P. Murad, Anthony K. Park, Brook Jeang, Yukiko Yamaguchi, Xin Yang, Ryan Urak, Lihong Weng, Wen-Chung Chang, Sarah Wright, Sumanta Pal, Robert E. Reiter, Anna M. Wu, Christine E. Brown, Stephen J. Forman
Publikováno v:
OncoImmunology, Vol 7, Iss 2 (2018)
Advancing chimeric antigen receptor (CAR)-engineered adoptive T cells for the treatment of solid cancers is a major focus in the field of immunotherapy, given impressive recent clinical responses in hematological malignancies. Prostate cancer may be
Externí odkaz:
https://doaj.org/article/629ee7d73f44415b8d4d8a86e5399e0c
Autor:
Brile Chung, Tor B. Stuge, John P. Murad, Georg Beilhack, Emily Andersen, Brian D. Armstrong, Jeffrey S. Weber, Peter P. Lee
Publikováno v:
Cell Reports, Vol 8, Iss 3, Pp 871-882 (2014)
Current vaccine conditions predominantly elicit low-avidity cytotoxic T lymphocytes (CTLs), which are non-tumor-cytolytic but indistinguishable by tetramer staining or enzyme-linked immunospot from high-avidity CTLs. Using CTL clones of high or low a
Externí odkaz:
https://doaj.org/article/902b3e2cf0e24ae092c8c0695e635456
Autor:
Christine E. Brown, Stephen J. Forman, Jana Portnow, Rahul Jandial, Josh Neman, Julie R. Ostberg, Wen-Chung Chang, Anthony K. Park, John P. Murad, Brenda Aguilar, Brook Jeang, Dileshni Tilakawardane, Saul J. Priceman
Figure S1: HER2 expression in BBM1 tumors. (a) Representative histology of HER2 expression in BBM1 tumors engrafted in mouse brain. N = normal brain, T = BBM1 tumor. Figure S2: Intraventricular HER2-BBζ CAR T cell therapy is effective against BBM1 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7cc3929561c27e45e1988f4a28e395
https://doi.org/10.1158/1078-0432.22463528.v1
https://doi.org/10.1158/1078-0432.22463528.v1
Autor:
Christine E. Brown, Stephen J. Forman, Jana Portnow, Rahul Jandial, Josh Neman, Julie R. Ostberg, Wen-Chung Chang, Anthony K. Park, John P. Murad, Brenda Aguilar, Brook Jeang, Dileshni Tilakawardane, Saul J. Priceman
Purpose: Metastasis to the brain from breast cancer remains a significant clinical challenge, and may be targeted with CAR-based immunotherapy. CAR design optimization for solid tumors is crucial due to the absence of truly restricted antigen express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a729ff4eff7c143e9f5ba84bd488dc
https://doi.org/10.1158/1078-0432.c.6525428
https://doi.org/10.1158/1078-0432.c.6525428
Autor:
Maria M. Abreu, Prasad S. Adusumilli, Behnam Badie, Rafet Basar, Rebecca Bellis, Ronald Blasberg, Barbara Breznik, Shyambabu Chaurasiya, Po-Chun Chen, Kevin Choong, Nishant Chovatiya, May Daher, Supriya Deshpande, Lisa Feldman, Timothy D. Folsom, Christina Fong, Yuman Fong, Jacqueline Gouvea, Anamarija Habič, Anahid Jewett, Sharyn I. Katz, Kawaljit Kaur, Meng-Wei Ko, Janko Kos, Derek Lee, Zhe Li, Emil Lou, Dipnarine Maharaj, Kelly Mahuron, Bernarda Majc, Sandro Matosevic, Branden S. Moriarity, John P. Murad, Ishwar Navin, Metka Novak, Robin Parihar, Anthony K. Park, Vineet Polineni, Vladimir Ponomarev, Saul J. Priceman, Hind Rafei, Jamie Rand, Katayoun Rezvani, Isabelle Rivière, Leonid Roshkovan, Saeed Sadeghi, Jasmeen Saini, Emanuela Senjor, Inna Serganova, Timothy K. Starr, Tamara Lah Turnsek, Alessia Volpe, Xiuyan Wang, Beau R. Webber, Paul Wong, Yanghee Woo, Jennifer Wu, Lili Yang, Yuan Yuan, Samuel Zeng, Amy Zhu
Publikováno v:
NK Cells in Cancer Immunotherapy: Successes and Challenges ISBN: 9780128226209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05036980bcfb2beeb32a5ae9f0c849aa
https://doi.org/10.1016/b978-0-12-822620-9.09986-9
https://doi.org/10.1016/b978-0-12-822620-9.09986-9
Publikováno v:
NK Cells in Cancer Immunotherapy: Successes and Challenges ISBN: 9780128226209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b844a664d62a7a1f94f731024128c64
https://doi.org/10.1016/b978-0-12-822620-9.00018-5
https://doi.org/10.1016/b978-0-12-822620-9.00018-5
Autor:
Hee Jun Lee, Yuki Yamaguchi, Jackson Gibson, Cody Cullen, John P. Murad, Anthony K. Park, Isabel Monroy, Cari Young, Lea Christian, Lauren Adkins, Lawrence Stern, Wen-Chung Chang, Catalina Martinez, Stephen J. Forman, Saul J. Priceman
Publikováno v:
Cancer Research. 83:4090-4090
While chimeric antigen receptor (CAR) T cells have received FDA approvals in treating hematological malignancies, clinical responses of CAR T cells for solid tumors have been underwhelming. Intense investigation is underway to improve CAR T cells tra