Zobrazeno 1 - 10
of 742
pro vyhledávání: '"John P. Moore"'
Autor:
John P. Moore, Brock Kuhlman, Jeanett Hansen, Leonardo Gomez, Bodil JØrgensen, Dorothea Bartels
Publikováno v:
Plants, Vol 13, Iss 16, p 2235 (2024)
Vegetative desiccation tolerance has evolved within the genera Craterostigma and Lindernia. A centre of endemism and diversification for these plants appears to occur in ancient tropical montane rainforests of east Africa in Kenya and Tanzania. Linde
Externí odkaz:
https://doaj.org/article/433f3c779a384d5d862cb1c5bd2da7bb
Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Autor:
Philippe Colin, Rajesh P. Ringe, Anila Yasmeen, Gabriel Ozorowski, Thomas J. Ketas, Wen-Hsin Lee, Andrew B. Ward, John P. Moore, P. J. Klasse
Publikováno v:
Retrovirology, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background Neutralizing antibodies (NAbs) protect against HIV-1 acquisition in animal models and show promise in treatment of infection. They act by binding to the viral envelope glycoprotein (Env), thereby blocking its receptor interactions
Externí odkaz:
https://doaj.org/article/f369c2c702f8496ebac50311e4de718b
Publikováno v:
Horticulturae, Vol 10, Iss 5, p 471 (2024)
The rest-breaking agent, hydrogen cyanamide (HC), can substitute insufficient chill unit accumulation in Vitis vinifera and induce uniform bud-break; however, due to its toxicity it is being banned. In South Africa, red seedless grapes, including V.
Externí odkaz:
https://doaj.org/article/3a053976f2ee4250b2dc5362b8a4bf0e
Publikováno v:
Plants, Vol 12, Iss 18, p 3202 (2023)
Priming agents are plant defence-inducing compounds which can prompt a state of protection but may also aid in plant growth and interactions with beneficial microbes. The synthetic strigolactones (±)-GR24 and Nijmegen-1 were evaluated as potential p
Externí odkaz:
https://doaj.org/article/89bf134f779d441da643f1d2281a45c1
Autor:
Weimin Liu, Ronnie M. Russell, Frederic Bibollet-Ruche, Ashwin N. Skelly, Scott Sherrill-Mix, Drew A. Freeman, Regina Stoltz, Emily Lindemuth, Fang-Hua Lee, Sarah Sterrett, Katharine J. Bar, Nathaniel Erdmann, Sigrid Gouma, Scott E. Hensley, Thomas Ketas, Albert Cupo, Victor M. Cruz Portillo, John P. Moore, Paul D. Bieniasz, Theodora Hatziioannou, Greer Massey, Mary-Beth Minyard, Michael S. Saag, Randall S. Davis, George M. Shaw, William J. Britt, Sixto M. Leal, Paul Goepfert, Beatrice H. Hahn
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 9, Pp 2454-2458 (2021)
Not all persons recovering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection develop SARS-CoV-2–specific antibodies. We show that nonseroconversion is associated with younger age and higher reverse transcription PCR cycle
Externí odkaz:
https://doaj.org/article/64493f6531fd464393624fb9de922352
Autor:
Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker, Neil P. King, Rogier W. Sanders, John P. Moore, Shane Crotty, Max Crispin, David C. Montefiori, Dennis R. Burton, William R. Schief, Guido Silvestri, Andrew B. Ward
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Here, the authors present cryoEMPEM, a method for high-resolution structural analysis of vaccine-elicited polyclonal antibody responses. They apply cryoEMPEM in combination with standard serology experiments to characterize the polyclonal antibody (p
Externí odkaz:
https://doaj.org/article/04ab87746dbe4d4ea81ab039e453c3ac
Autor:
Kwinten Sliepen, Edith Schermer, Ilja Bontjer, Judith A. Burger, Réka Felfödiné Lévai, Philipp Mundsperger, Philip J. M. Brouwer, Monica Tolazzi, Atilla Farsang, Dietmar Katinger, John P. Moore, Gabriella Scarlatti, Robin J. Shattock, Quentin J. Sattentau, Rogier W. Sanders
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-8 (2021)
Abstract The immunogenicity of HIV-1 envelope (Env) trimers is generally poor. We used the clinically relevant ConM SOSIP trimer to compare the ability of different adjuvants (squalene emulsion, ISCOMATRIX, GLA-LSQ, and MPLA liposomes) to support neu
Externí odkaz:
https://doaj.org/article/3493c21b5fee4dc2a902a4cfd21185c1
Autor:
Edgar A. Hodge, Gajendra S. Naika, Sally M. Kephart, Adam Nguyen, Richard Zhu, Mark A. Benhaim, Wenjin Guo, John P. Moore, Shiu-Lok Hu, Rogier W. Sanders, Kelly K. Lee
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104449- (2022)
Summary: The envelope glycoprotein (Env) is the sole target for neutralizing antibodies against HIV and the most rapidly evolving, variable part of the virus. High-resolution structures of Env trimers captured in the pre-fusion, closed conformation h
Externí odkaz:
https://doaj.org/article/935242cc58c844479c66c9ed25cfbdb2
Autor:
Philip J. M. Brouwer, Aleksandar Antanasijevic, Marlon de Gast, Joel D. Allen, Tom P. L. Bijl, Anila Yasmeen, Rashmi Ravichandran, Judith A. Burger, Gabriel Ozorowski, Jonathan L. Torres, Celia LaBranche, David C. Montefiori, Rajesh P. Ringe, Marit J. van Gils, John P. Moore, Per Johan Klasse, Max Crispin, Neil P. King, Andrew B. Ward, Rogier W. Sanders
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract The HIV-1 envelope glycoprotein trimer is poorly immunogenic because it is covered by a dense glycan shield. As a result, recombinant Env glycoproteins generally elicit inadequate antibody levels that neutralize clinically relevant, neutrali
Externí odkaz:
https://doaj.org/article/6d2ce266cff0455eb80fcc32049d700d
Autor:
Thomas J. Ketas, Devidas Chaturbhuj, Victor M. Cruz Portillo, Erik Francomano, Encouse Golden, Sharanya Chandrasekhar, Gargi Debnath, Randy Diaz-Tapia, Anila Yasmeen, Kyle D. Kramer, Tarek Munawar, Wilhem Leconet, Zhen Zhao, Philip J.M. Brouwer, Melissa M. Cushing, Rogier W. Sanders, Albert Cupo, P.J. Klasse, Silvia C. Formenti, John P. Moore
Publikováno v:
Pathogens and Immunity, Vol 6, Iss 1 (2021)
The approved Pfizer and Moderna mRNA vaccines are well known to induce serum antibody responses to the SARS-CoV-2 Spike (S)-protein. However, their abilities to elicit mucosal immune responses have not been reported. Saliva antibodies represent mucos
Externí odkaz:
https://doaj.org/article/e713a3a090fc4fe493126bb76a32e1a3