Výsledky vyhledávání - "John P. Mckearn"

The enhanced in vitro hematopoietic activity of leridistim, a chimeric dual G-CSF and IL-3 receptor agonist

Autor: W. G. Smith, S. R. Braford, M. E. Bremer, J. K. Welply, A. L. Abegg, P. D. Doshi, T. L. Thurman, M. L. Evans, John P. McKearn, A. M. Donnelly, M. H. Caparon, J. G. Giri, S. C. Bauer, L. E. Vickery

Publikováno v: Leukemia. 16:316-326

The in vitro activity of leridistim was characterized for cell proliferation, generation of colony-forming units (CFU) and differentiation of CD34+ cells. In AML-193.1.3 cells, leridistim exhibited a significant increase in potency compared to rhG-CS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033e8d99395fc232a42296bf00b4ae3e
https://doi.org/10.1038/sj.leu.2402366

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Modulation of the Binding Affinity of Myelopoietins for the Interleukin-3 Receptor by the Granulocyte Colony-Stimulating Factor Receptor Agonist

Autor: Yatin R. Gokarn, Edward E. Remsen, Yiqing G. Feng, Joseph B. Monahan, Cindy Jarvis, Roger J. Schilling, Barbara K. Klein, William F. Hood, Joseph K. Welply, Jeng-Jong J. Shieh, John P. Mckearn, William D. Joy, Joseph O. Polazzi

Publikováno v: Biochemistry. 40:13598-13606

Myelopoietins (MPOs) are a family of recombinant chimeric proteins that are both interleukin-3 (IL-3) receptor and granulocyte colony-stimulating factor (G-CSF) receptor agonists. In this study, MPO molecules containing one of three different IL-3 re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c59248c16b6f7f16294d6429fcf0cec
https://doi.org/10.1021/bi010590t

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Progenipoietin-1

Autor: William H. Fleming, John P. McKearn, Jean M Mulcahy, Philip R. Streeter

Publikováno v: Experimental Hematology. 29:943-951

Objective Progenipoietin-1 is an agonist of both the granulocyte colony-stimulating factor and fetal liver tyrosine kinase-3 receptors capable of inducing the proliferation of multiple hematopoietic cell lineages. The potential of progenipoietin-1 to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db7d2c856e09e7f0409533753a6d1d54
https://doi.org/10.1016/s0301-472x(01)00675-0

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Phage display mutagenesis of the chimeric dual cytokine receptor agonist myelopoietin

Autor: John P. McKearn, A. M. Donnelly, R Ibdah, J Klover, C Van Valkenburgh, A. L. Abegg, S Merlin, E Rowold, S. C. Lee

Publikováno v: Leukemia. 15:1277-1285

Myelopoietins comprise a class of chimeric cytokine receptor agonists consisting of an hIL-3 (human interleukin-3) receptor agonist and an hG-CSF (human granulocyte colony-stimulating factor) receptor agonist linked head-to-tail at their respective c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34a62773c55643968d4cd2e5333b090
https://doi.org/10.1038/sj.leu.2402163

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Promegapoietin‐1a, an Engineered Chimeric IL‐3 and Mpl‐L Receptor Agonist, Stimulates Hematopoietic Recovery in Conventional and Abbreviated Schedules Following Radiation‐Induced Myelosuppression in Nonhuman Primates

Autor: John P. Mckearn, Judith G. Giri, Walter G. Smith, Ned R. Siegel, Ann M. Farese, Thomas J. MacVittie

Publikováno v: STEM CELLS. 19:329-338

Promegapoietin-1a (PMP-1a), a multifunctional agonist for the human interleukin 3 and Mpl receptors, was evaluated for its ability to stimulate hematopoietic reconstitution in nonhuman primates following severe radiation-induced myelosuppression. Ani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b768cc1a8fc1d859334857dedd9ab291
https://doi.org/10.1634/stemcells.19-4-329

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Progenipoietins

Autor: Philip R. Streeter, William F. Hood, Tammy L. Thurman, John P. McKearn, Joseph K. Welply, Larry E Kahn, Woulfe Susan L, Nancy I. Minster, Joseph B. Monahan, Lillian E Vickery

Publikováno v: Experimental Hematology. 29:41-50

Objective The progenipoietins, a class of engineered proteins containing both fetal liver tyrosine kinase-3 and granulocyte colony-stimulating factor receptor agonist activities, were functionally characterized in vitro and in vivo. Materials and Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d90635cd6e1fbecfb24c032d0c2be6da
https://doi.org/10.1016/s0301-472x(00)00616-0

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Myelopoietin, an engineered chimeric IL-3 and G-CSF receptor agonist, stimulates multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression

Autor: Walter G. Smith, Thomas J. MacVittie, Charles M. Baum, Ann M. Farese, Earl Burton, John P. McKearn

Publikováno v: Blood. 95:837-845

Myelopoietins (MPOs) constitute a family of engineered, chimeric molecules that bind and activate the IL-3 and G-CSF receptors on hematopoietic cells. This study investigated the in vivo hematopoietic response of rhesus monkeys administered MPO after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22ccd6498890227070fb6bf427932476
https://doi.org/10.1182/blood.v95.3.837.003k08_837_845

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Use of combinatorial mutagenesis to select for multiply substituted human interleukin-3 variants with improved pharmacologic properties

Autor: Jeng-Jong Shieh, Peter O. Olins, Maire Helena Caparon, William F. Hood, Kumnan Paik, Ann M. Donnelly, Bauer Christopher S, John P. McKearn, Sarah R. Braford, Polazzi Joseph O, John W. Thomas, Jon A. Klover, Alan Michael Easton, David L. Zeng, Mark Allen Abrams, Joseph K. Welply, Barbara K. Klein

Publikováno v: Experimental Hematology. 27:1746-1756

A combinatorial mutagenesis strategy was used to create a collection of nearly 500 variants of human interleukin 3 (IL-3), each with four to nine amino acid substitutions clustered within four linear, nonoverlapping regions of the polypeptide. The va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4c1a8be21dd8999107c60b154356b0
https://doi.org/10.1016/s0301-472x(99)00118-6

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Myelopoietin, a chimeric agonist of human interleukin 3 and granulocyte colony-stimulating factor receptors, mobilizes CD34+ cells that rapidly engraft lethally x-irradiated nonhuman primates

Autor: Lisa B. Lind, John P. McKearn, Thomas A. Davis, Thomas J. MacVittie, Ann M. Farese

Publikováno v: Experimental Hematology. 27:1557-1568

Myelopoietin (MPO), a multifunctional agonist of interleukin 3 and granulocyte colony-stimulating factor (G-CSF) receptors, was evaluated for its ability to mobilize hematopoietic colony-forming cells (CFC) and CD34+ cells relative to control cytokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af0650426aa85fda8d17dea68571e5c
https://doi.org/10.1016/s0301-472x(99)00092-2

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Circular Permutation of Granulocyte Colony-Stimulating Factor

Autor: Jeng-Jong Shieh, Tammy L. Thurman, William D. Joy, William F. Hood, Charles A. McWherter, Edith S. Grabbe, Linda L. Zurfluh, Yiqing Feng, Ann L. Abegg, Minnerly John C, John P. McKearn

Publikováno v: Biochemistry. 38:4553-4563

The sequence of granulocyte colony-stimulating factor (G-CSF) has been circularly permuted by introducing new chain termini into interhelical loops and by constraining the N- and C-terminal helices, either by direct linkage of the termini (L0) or by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c130fbd2bbf1351d294571621878e78b
https://doi.org/10.1021/bi982224o

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