Zobrazeno 1 - 10
of 109
pro vyhledávání: '"John P. MacManus"'
Transient focal ischaemia was produced in rat right neocortex by temporary middle cerebral artery occlusion. DNA damage was visualized in situ in cells of this right hemisphere but not in the contralateral hemisphere. The extracted damaged DNA exhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85ca677b5c8fd5d4863c09943768efd
https://ora.ox.ac.uk/objects/uuid:a7a121d7-abad-4823-aa98-4bbbdaaeeed3
https://ora.ox.ac.uk/objects/uuid:a7a121d7-abad-4823-aa98-4bbbdaaeeed3
Autor:
Edward Preston, John P. MacManus, Alastair M. Buchan, Teena Walker, Ingrid Rasquinha, Irene E. Hill
The time course of appearance of cells with DNA damage was studied in rats following transient severe forebrain ischemia. This DNA damage could be detected by in situ end-labeling on brain sections. The breaks in DNA appeared selectively by day 1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9aee035866a3db800171bd5acfc95a8
https://doi.org/10.1038/jcbfm.1995.94
https://doi.org/10.1038/jcbfm.1995.94
Activation of DNA-Dependent Protein Kinase May Play a Role in Apoptosis of Human Neuroblastoma Cells
Publikováno v:
Journal of Neurochemistry. 72:933-942
Treating SH-SY5Y human neuroblastoma cells with 1 microM staurosporine resulted in a three- to fourfold higher DNA-dependent protein kinase (DNA-PK) activity compared with untreated cells. Time course studies revealed a biphasic effect of staurospori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daea5fbb212be1b18aaf4e63c5f1a32b
https://doi.org/10.1046/j.1471-4159.1999.0720933.x
https://doi.org/10.1046/j.1471-4159.1999.0720933.x
Autor:
Willard J. Costain, Jacqueline Slinn, Xiaoqi Xie, Edward Preston, Christian C Luebbert, Tyson E. Graber, John P. MacManus, Ingrid Rasquinha
Publikováno v:
Brain Research. 1094:24-37
Mammalian genomes are burdened with a large heterogeneous group of endogenous replication defective retroviruses (retrotransposons). Previously, we identified a transcript resembling a virus-like 30S (VL30) retrotransposon increasing in mouse brain f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964965558685b042f485fc329f2e7a17
https://doi.org/10.1016/j.brainres.2006.03.120
https://doi.org/10.1016/j.brainres.2006.03.120
Autor:
Ingrid Rasquinha, Bogdan Zurakowski, Edward Preston, Ming Jian, Jackie Webster, John P. MacManus
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 23:1020-1028
Because of observations that cultured neurons from mice deficient in the transcription factor E2F1 exhibit resistance after treatment with a wide variety of cell-death inducers, the authors investigated whether resistance extended to a cerebral ische
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613b80468b9c1c24623bb4860672b4f9
https://doi.org/10.1097/01.wcb.0000084249.20114.fa
https://doi.org/10.1097/01.wcb.0000084249.20114.fa
Autor:
John P. MacManus, Teena Walker, Emily Cowan, Mike Dove, Ingrid Rasqinha, Nick Ohan, Sheng T. Hou
Publikováno v:
Journal of Neurochemistry. 78:287-297
The E2F1 transcription factor plays an important role in promoting neuronal apoptosis; however, it is not clear how E2F1 does this. Here we show that E2F1 is involved in dopamine (DA)-evoked apoptosis in cerebellar granule neurons (CGNs). E2F1 -/- CG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09b229a6b329afe586b35a242d9a8db4
https://doi.org/10.1046/j.1471-4159.2001.00402.x
https://doi.org/10.1046/j.1471-4159.2001.00402.x
Autor:
Paul Morley, James Paris, Tania F. Gendron, Andrei Edwards, Geoff Mealing, Antoine M. Hakim, Allison Lou, Sheng T. Hou, John P. MacManus
Publikováno v:
Journal of Neurochemistry. 78:316-324
The E2F1 transcription factor modulates neuronal apoptosis induced by staurosporine, DNA damage and β-amyloid. We demonstrate E2F1 involvement in neuronal death induced by the more physiological oxygen-glucose deprivation (OGD) in mouse cortical cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb61d12a6f8632d937452cbbd38581c
https://doi.org/10.1046/j.1471-4159.2001.00423.x
https://doi.org/10.1046/j.1471-4159.2001.00423.x
Autor:
Ping-An Li, Katalin Csiszar, Charles D. Boyd, Bo K. Siesjö, John P. MacManus, Ingrid Rasquinha, Qing Ping He
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 21:568-576
Previous histopathologic results have suggested that one mechanism whereby hyperglycemia (HG) leads to exaggerated ischemic damage involves fragmentation of DNA. DNA fragmentation in normoglycemia (NG) and HG rats subjected to 30 minutes of forebrain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a6e0128379a03c1f5d60f7860aa3c9
https://doi.org/10.1097/00004647-200105000-00011
https://doi.org/10.1097/00004647-200105000-00011
Autor:
Alastair M. Buchan, John P. MacManus
Publikováno v:
Journal of Neurotrauma. 17:899-914
This review examines the appearance of hallmarks of apoptosis following experimental stroke. The reviewed literature leaves no doubt that ischemic cell death in the brain is active, that is, requires energy; is gene directed, that is, requires new ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee1a82bbae0505889b641804d0687f9
https://doi.org/10.1089/neu.2000.17.899
https://doi.org/10.1089/neu.2000.17.899
Publikováno v:
NeuroReport. 10:2711-2714
E2F1+/- mice subjected to 2 h middle cerebral artery occlusion developed an infarct of 77.0 +/- 3.2 mm3 (mean +/- s.e.m., n = 15) in the ischemic hemisphere after 24 h reperfusion. A significantly smaller infarct of 58.8 +/- 4.8 mm3 (n = 15; p < 0.01
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180cfee9f390d241ca998e9725f75068
https://doi.org/10.1097/00001756-199909090-00004
https://doi.org/10.1097/00001756-199909090-00004