Zobrazeno 1 - 10
of 22
pro vyhledávání: '"John P. Kowalski"'
Autor:
Katherine A. Sitko, Lai Hong Wong, Allan E. Rettie, Gabriel Boyle, Clara J. Amorosi, John P. Kowalski, Melissa A Chiasson, Douglas M. Fowler, Maitreya J. Dunham, Matthew G. McDonald
Publikováno v:
Am J Hum Genet
CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these therapeutics. In particular, the anti-coagulant warfarin is prescribed to over 15 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246f02008e4beb6e3257ac1171b8faf7
https://doi.org/10.1016/j.ajhg.2021.07.001
https://doi.org/10.1016/j.ajhg.2021.07.001
Autor:
Guillermo S Romano Ibarra, Biswajit Paul, Blythe D Sather, Patrick M Younan, Karen Sommer, John P Kowalski, Malika Hale, Barry Stoddard, Jordan Jarjour, Alexander Astrakhan, Hans-Peter Kiem, David J Rawlings
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
A naturally occurring 32-base pair deletion of the HIV-1 co-receptor CCR5 has demonstrated protection against HIV infection of human CD4+ T cells. Recent genetic engineering approaches using engineered nucleases to disrupt the gene and mimic this mut
Externí odkaz:
https://doaj.org/article/9a753dd3c9794ca9b239d6c43c9c7b98
Autor:
Michele Scian, Dale Whittington, Matthew G. McDonald, Constanze Wiek, Miklos Guttman, Allan E. Rettie, John P. Kowalski, Marco Girhard, Helmut Hanenberg
Publikováno v:
Chemical Research in Toxicology. 32:2488-2498
Cytochrome P450 4B1 (CYP4B1) has been explored as a candidate enzyme in suicide gene systems for its ability to bioactivate the natural product 4-ipomeanol (IPO) to a reactive species that causes cytotoxicity. However, metabolic limitations of IPO ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ede64dbcf88b97c2ba557daa0505edb
https://doi.org/10.1021/acs.chemrestox.9b00330
https://doi.org/10.1021/acs.chemrestox.9b00330
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 51(8)
8-[(1H-1,2,3-benzotriazol-1-yl)amino]octanoic acid (8-BOA) was recently identified as a selective and potent mechanism-based inactivator (MBI) of breast cancer-associated CYP4Z1 and exhibited favourable inhibitory activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85503e3944544db1d341a47866085e5c
https://pubmed.ncbi.nlm.nih.gov/33993844
https://pubmed.ncbi.nlm.nih.gov/33993844
8‐[(1H‐1,2,3‐benzotriazol‐1‐yl)amino]octanoic acid (8-BOA) was recently identified as a selective and potent mechanism-based inactivator (MBI) of breast cancer-associated CYP4Z1 and exhibited favourable inhibitory activity in vitro, thus me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b53bcc8bf55a84f9624d1c38c8807f
Autor:
Catherine K. Yeung, John P. Kowalski, Allan E. Rettie, Matthew G. McDonald, Kenneth E. Thummel, Constanze Wiek, Lindsay M. Henderson, Helmut Hanenberg, Amanda L. Johnson, Sutapa Ray
Publikováno v:
J Pharmacol Exp Ther
CYP2C9 is a major form of human liver cytochrome P450 that is responsible for the oxidative metabolism of several widely used low-therapeutic index drugs, including (S)-warfarin and phenytoin. In a cohort of Alaska Native people, ultrarare or novel C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47b4bcc698d24abb68096d10735750b
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85088177937
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85088177937
Autor:
Allan E. Rettie, Constanze Wiek, John P. Kowalski, Helmut Hanenberg, Robert D. Pelletier, Matthew G. McDonald
Mammary-tissue-restricted cytochrome P450 4Z1 (CYP4Z1) has garnered interest for its potential role in breast cancer progression. CYP4Z1-dependent metabolism of arachidonic acid preferentially generates 14,15-epoxyeicosatrienoic acid (14,15-EET), a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270dcc3cbf99d1f1ecfd98c061ed0fa2
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85084692722
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85084692722
Autor:
Katherine A. Sitko, Allan E. Rettie, Maitreya J. Dunham, Rheem A. Totah, Byron Gallis, Abhinav Nath, John P. Kowalski, Lorela Paco, Sutapa Ray, Matthew G. McDonald, Douglas M. Fowler, Clara J. Amorosi
Publikováno v:
Drug Metabolism and Disposition. 45:1364-1371
CYP4Z1 is an "orphan" cytochrome P450 (P450) enzyme that has provoked interest because of its hypothesized role in breast cancer through formation of the signaling molecule 20-hydroxyeicosatetraenoic acid (20-HETE). We expressed human CYP4Z1 in Sacch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7a38e1b612a701f0f2c760f61bbaaab
https://doi.org/10.1124/dmd.117.078188
https://doi.org/10.1124/dmd.117.078188
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S27-S28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2b37cafde442ab2d4e603de63708be7
https://doi.org/10.1016/j.dmpk.2020.04.020
https://doi.org/10.1016/j.dmpk.2020.04.020
Autor:
Allan E. Rettie, Constanze Wiek, Marco Girhard, Michael C. Hutter, John P. Kowalski, Florian A. Thesseling
Publikováno v:
Arch Biochem Biophys
CYP4B1 is an enigmatic mammalian cytochrome P450 monooxygenase acting at the interface between xenobiotic and endobiotic metabolism. A prominent CYP4B1 substrate is the furan pro-toxin 4-ipomeanol (IPO). Our recent investigation on metabolism of IPO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bef389c3be6f8c17953117f2cca741
https://pubmed.ncbi.nlm.nih.gov/31801692
https://pubmed.ncbi.nlm.nih.gov/31801692