Zobrazeno 1 - 10
of 178
pro vyhledávání: '"John P. Hutchinson"'
Autor:
Chantelle Carbonell BHSc, John M. Hutchinson BHSc, Robert J. Hilsden MD, PhD, FRCPC, Huiming Yang MD, MSc, FRCPC, Darren R. Brenner PhD
Publikováno v:
Cancer Control, Vol 31 (2024)
Screening and early detection is one of the most effective approaches to reduce the population-level impact of cancer. Novel approaches to screening such as multi-cancer early detection tests (MCEDs) may further reduce cancer incidence and mortality.
Externí odkaz:
https://doaj.org/article/aae5fdd27752413c9363d127da977f0c
Publikováno v:
BMJ Paediatrics Open, Vol 8, Iss 1 (2024)
Objective We investigated sudden unexpected death in infancy (SUDI) autopsy data from 1996 to 2015 inclusive, comparing findings from infants with and without pre-existing medical conditions.Design Large, retrospective single-centre autopsy series.Se
Externí odkaz:
https://doaj.org/article/7f6d553088e8452992097eb9be6faee9
Autor:
John R. Hutchinson, Emily V. Pringle
Publikováno v:
PeerJ, Vol 12, p e17675 (2024)
Common hippopotamuses (hippos) are among the largest extant land mammals. They thus offer potential further insight into how giant body size on land influences locomotor patterns and abilities. Furthermore, as they have semi-aquatic habits and unusua
Externí odkaz:
https://doaj.org/article/738beab839d34e5a9744a7ee695699a2
Publikováno v:
PeerJ, Vol 12, p e16821 (2024)
The force a muscle generates is dependent on muscle structure, in which fibre length, pennation angle and tendon slack length all influence force production. Muscles are not preserved in the fossil record and these parameters must be estimated when c
Externí odkaz:
https://doaj.org/article/e3f261e43f34467ea38c49d08379b531
Autor:
Sophie Macaulay, Tatjana Hoehfurtner, Samuel R. R. Cross, Ryan D. Marek, John R. Hutchinson, Emma R. Schachner, Alice E. Maher, Karl T. Bates
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Here, the authors track the evolution of mass distribution through bird evolution challenging suggested coupling between body shape and centre-of-mass position, and instead showing that crouched bipedalism evolved after powered flight.
Externí odkaz:
https://doaj.org/article/fcc3e901e6c24784aab2ba8b6335a795
Autor:
David B. Chou, Brooke A. Furlong, Ryan R. Posey, Christos Kyprianou, Lucy R. O’Sullivan, Rhiannon David, Suzanne J. Randle, Urszula M. Polanska, Jon Travers, Jelena Urosevic, John N. Hutchinson, Jianwei Che, Anna M. Howley, Robert P. Hasserjian, Rachelle Prantil-Baun, Donald E. Ingber
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Patients treated with Aurora kinase inhibitors experience dose-limiting neutropenia while other cytopenias are rare. Here, Chou et al. show that this cell-type specific side effect is partly explained by loss of drug efflux pump expression during neu
Externí odkaz:
https://doaj.org/article/30b138eaa22049aea33459bc0a7f87f2
Publikováno v:
Royal Society Open Science, Vol 10, Iss 8 (2023)
During the Mesozoic, non-avian theropods represented one of the most successful clades globally distributed, with a wide diversity of forms. An example is the clade Megalosauroidea, which included medium- to large-bodied forms. Here, we analyse the m
Externí odkaz:
https://doaj.org/article/49a7808505ef4771ba4715c3d9bd1a99
Autor:
Saranna Fanning, Haley Cirka, Jennifer L. Thies, Jooyoung Jeong, Sarah M. Niemi, Joon Yoon, Gary P. H. Ho, Julian A. Pacheco, Ulf Dettmer, Lei Liu, Clary B. Clish, Kevin J. Hodgetts, John N. Hutchinson, Christina R. Muratore, Guy A. Caldwell, Kim A. Caldwell, Dennis Selkoe
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract Synucleinopathy (Parkinson’s disease (PD); Lewy body dementia) disease-modifying treatments represent a huge unmet medical need. Although the PD-causing protein α-synuclein (αS) interacts with lipids and fatty acids (FA) physiologically
Externí odkaz:
https://doaj.org/article/a05e96cff1274ee38def6a5cf8769047
Autor:
Oliver E. Demuth, Ashleigh L. A. Wiseman, Julia van Beesel, Heinrich Mallison, John R. Hutchinson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Biomechanical models and simulations of musculoskeletal function rely on accurate muscle parameters, such as muscle masses and lines of action, to estimate force production potential and moment arms. These parameters are often obtained throu
Externí odkaz:
https://doaj.org/article/d1da1ff135294562a6b6c09fc62e54e9
Publikováno v:
Royal Society Open Science, Vol 10, Iss 1 (2023)
Birds and crocodylians are the only remaining members of Archosauria (ruling reptiles) and they exhibit major differences in posture and gait, which are polar opposites in terms of locomotor strategies. Their broader lineages (Avemetatarsalia and Pse
Externí odkaz:
https://doaj.org/article/043ea9c49919408d89fe6cb01dbc922a