Zobrazeno 1 - 10
of 20
pro vyhledávání: '"John P. Hawkins"'
Autor:
John P. Hawkins
Mayas, and indeed all Guatemalans, are currently experiencing the collapse of their way of life. This collapse is disrupting ideologies, symbols, life practices, and social structures that have undergirded their society for almost five hundred years,
Autor:
John Kendall Hawkins
Publikováno v:
Fafnir, Vol 9, Iss 2, Pp 162-168 (2022)
Externí odkaz:
https://doaj.org/article/d3f16ff02ada4cd3b911fb6d75ae39fe
Autor:
Natalia Levshina, John A. Hawkins
Publikováno v:
Linguistic Typology at the Crossroads, Vol 2, Iss 1, Pp 94-120 (2022)
We investigate the correlations between A- and P-lability for verbal arguments with other typological parameters using large, syntactically annotated corpora of online news in 28 languages. To estimate how much lability is observed in a language, we
Externí odkaz:
https://doaj.org/article/68eaa344280b402ebe5a4d936dd43d8d
Autor:
Behrouz Eslami-Mossallam, Misha Klein, Constantijn V. D. Smagt, Koen V. D. Sanden, Stephen K. Jones, John A. Hawkins, Ilya J. Finkelstein, Martin Depken
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Cas9 off-target sites can be predicted by many bioinformatics tools. Here the authors present low complexity mechanistic model that characterizes SpCas9 kinetics in free-energy terms, allowing quantitative prediction of off-target activity in bulk-bi
Externí odkaz:
https://doaj.org/article/8ce17f4dfe3843928f961470b5546a13
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100521- (2021)
Summary: CRISPR interference is an increasingly popular method for perturbing gene expression. Guided by single-guide RNAs (sgRNAs), nuclease-deficient Cas9 proteins bind to specific DNA sequences and hinder transcription. Specificity is achieved thr
Externí odkaz:
https://doaj.org/article/59c63be3b5ae4335ae0d8a99663ae003
Autor:
Xuan Jiang, John S. Hawkins, Jerry Lee, Carlos O. Lizama, Frank L. Bos, Joan P. Zape, Prajakta Ghatpande, Yongbo Peng, Justin Louie, Giorgio Lagna, Ann C. Zovein, Akiko Hata
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Hematopoietic stem and progenitor cells are generated first from the vascular endothelium of the dorsal aorta and then the fetal liver but what regulates this switch is unknown. Here, the authors show that changing miRNA biogenesis and leukotriene B4
Externí odkaz:
https://doaj.org/article/811b54bd0de3489e841c1856c5f439e4
Autor:
Christopher E. Schmitt, Blanca M. Morales, Ellen M. H. Schmitz, John S. Hawkins, Carlos O. Lizama, Joan P. Zape, Edward C. Hsiao, Ann C. Zovein
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-9 (2017)
Abstract Background Non-integrating episomal vectors have become an important tool for induced pluripotent stem cell reprogramming. The episomal vectors carrying the “Yamanaka reprogramming factors” (Oct4, Klf, Sox2, and L-Myc + Lin28) are critic
Externí odkaz:
https://doaj.org/article/f338adfb1d634d2bb7e8d3969ad11652
Autor:
Gloria Ruiz-Gómez, John C Hawkins, Jenny Philipp, Georg Künze, Robert Wodtke, Reik Löser, Karim Fahmy, M Teresa Pisabarro
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154046 (2016)
Tackling protein interfaces with small molecules capable of modulating protein-protein interactions remains a challenge in structure-based ligand design. Particularly arduous are cases in which the epitopes involved in molecular recognition have a no
Externí odkaz:
https://doaj.org/article/6c75ecc614f94652adbdc16933160916
Autor:
Melinda Ng, Esther Ndungo, Maria E Kaczmarek, Andrew S Herbert, Tabea Binger, Ana I Kuehne, Rohit K Jangra, John A Hawkins, Robert J Gifford, Rohan Biswas, Ann Demogines, Rebekah M James, Meng Yu, Thijn R Brummelkamp, Christian Drosten, Lin-Fa Wang, Jens H Kuhn, Marcel A Müller, John M Dye, Sara L Sawyer, Kartik Chandran
Publikováno v:
eLife, Vol 4 (2015)
Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon he
Externí odkaz:
https://doaj.org/article/a4ca56856f3e47a9ba72fff1209120bf
Autor:
John P. Hawkins
In 1998, Hurricane Mitch pounded the isolated village of Santa Catarina Ixtahuacán in mountainous western Guatemala, destroying many homes. The experience traumatized many Ixtahuaquenses. Much of the community relocated to be safer and closer to tra