Zobrazeno 1 - 10
of 22
pro vyhledávání: '"John P. Gillies"'
Autor:
Shuwen He, John P. Gillies, Juliana L. Zang, Carmen M. Córdoba-Beldad, Io Yamamoto, Yasuhiro Fujiwara, Julie Grantham, Morgan E. DeSantis, Hiroki Shibuya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Male meiosis relies on canonical centrosomes for spindle formation, but how this differs from acentrosomal oocyte meiosis is unclear. Here they show that spindle formation in sperm relies on DYNLRB2, similar to the activity of DYNLRB1 in mitotic cell
Externí odkaz:
https://doaj.org/article/b077dccc14b24ed19264b85d32718b99
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cytoplasmic dynein-1 (dynein) is the primary microtubule minus-end directed molecular motor in most eukaryotes. As such, dynein has a broad array of functions that range from driving retrograde-directed cargo trafficking to forming and focusing the m
Externí odkaz:
https://doaj.org/article/8eb4940d87ce4d409c2857df702e83de
Autor:
Ritvija Agrawal, John P Gillies, Juliana L Zang, Jingjing Zhang, Sharon R Garrott, Hiroki Shibuya, Jayakrishnan Nandakumar, Morgan E DeSantis
Publikováno v:
eLife, Vol 11 (2022)
Dynein harnesses ATP hydrolysis to move cargo on microtubules in multiple biological contexts. Dynein meets a unique challenge in meiosis by moving chromosomes tethered to the nuclear envelope to facilitate homolog pairing essential for gametogenesis
Externí odkaz:
https://doaj.org/article/8cd9e357cd00482caea76adfd06dae58
Autor:
John P Gillies, Janice M Reimer, Eva P Karasmanis, Indrajit Lahiri, Zaw Min Htet, Andres E Leschziner, Samara L Reck-Peterson
Publikováno v:
eLife, Vol 11 (2022)
The lissencephaly 1 gene, LIS1, is mutated in patients with the neurodevelopmental disease lissencephaly. The Lis1 protein is conserved from fungi to mammals and is a key regulator of cytoplasmic dynein-1, the major minus-end-directed microtubule mot
Externí odkaz:
https://doaj.org/article/0c338fe5a65746bb99102d46fccf8b0d
Autor:
Sharon R Garrott, John P Gillies, Aravintha Siva, Saffron R Little, Rita El Jbeily, Morgan E DeSantis
Publikováno v:
bioRxiv
Dynein is the primary minus-end-directed microtubule motor [1]. To achieve activation, dynein binds to the dynactin complex and an adaptor to form the “activated dynein complex” [2, 3]. The protein Lis1 aids activation by binding to dynein and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3c1e5b7f5c13ca85ec60f12728af47
https://europepmc.org/articles/PMC9900795/
https://europepmc.org/articles/PMC9900795/
Cytoplasmic dynein-1 (dynein) is an AAA+ motor that transports intracellular cargos towards the microtubule minus end. Lissencephaly-1 (Lis1) binds to the AAA+ ring and stalk of dynein’s motor domain and promotes the assembly of active dynein compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::436384dd336e8b80a91da997d47b842d
https://doi.org/10.1101/2022.06.02.494578
https://doi.org/10.1101/2022.06.02.494578
Autor:
Ritvija Agrawal, John P Gillies, Juliana L Zang, Jingjing Zhang, Sharon R Garrott, Hiroki Shibuya, Jayakrishnan Nandakumar, Morgan E DeSantis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3736edec25c04593676a8157d064ddaf
https://doi.org/10.7554/elife.78201.sa2
https://doi.org/10.7554/elife.78201.sa2
Autor:
Sharon R. Garrott, John P. Gillies, Aravintha Siva, Saffron R. Little, Rita El Jbeily, Morgan E. DeSantis
Publikováno v:
Journal of Biological Chemistry. :104735
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79321686abf8e81f1ce9544dbea2c016
https://doi.org/10.1016/j.jbc.2023.104735
https://doi.org/10.1016/j.jbc.2023.104735
Autor:
John P Gillies, Janice M Reimer, Eva P Karasmanis, Indrajit Lahiri, Zaw Min Htet, Andres E Leschziner, Samara L Reck-Peterson
Publikováno v:
eLife, Vol 11 (2022)
The lissencephaly 1 gene, LIS1, is mutated in patients with the neurodevelopmental disease lissencephaly. The Lis1 protein is conserved from fungi to mammals and is a key regulator of cytoplasmic dynein-1, the major minus-end-directed microtubule mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fabca1f94be8bc373cad4a42fe72cf
https://pubmed.ncbi.nlm.nih.gov/34994688
https://pubmed.ncbi.nlm.nih.gov/34994688