Zobrazeno 1 - 10
of 73
pro vyhledávání: '"John P. Gibbs"'
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 395-404 (2021)
Antibody drug conjugates (ADCs) provide targeted delivery of cytotoxic agents directly inside tumor cells. However, many ADCs targeting solid tumors have exhibited limited clinical efficacy, in part, due to insufficient penetration within tumors. To
Externí odkaz:
https://doaj.org/article/312cea22690440858ae4609ed1a38617
Autor:
Quyen D. Chu, John F. Gibbs, John M. Lyons, Tingting Li, Mei-Chin Hsieh, Yong Yi, Xiao-Cheng Wu
Publikováno v:
JCO Global Oncology, Vol , Iss 7, Pp 183-184 (2021)
Externí odkaz:
https://doaj.org/article/edb362c068d64f638386f57583ef84db
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 395-404 (2021)
Clinical and Translational Science
Clinical and Translational Science
Antibody drug conjugates (ADCs) provide targeted delivery of cytotoxic agents directly inside tumor cells. However, many ADCs targeting solid tumors have exhibited limited clinical efficacy, in part, due to insufficient penetration within tumors. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6284a8063769d0eae78addf5c7cd38bc
https://doaj.org/article/312cea22690440858ae4609ed1a38617
https://doaj.org/article/312cea22690440858ae4609ed1a38617
Autor:
Rohit Sharma, Thomas A. Mace, Scott I. Abrams, Jason W.-L. Eng, Danielle Y. F. Twum, Peng Peng, John F. Gibbs, Rosemarie Pitoniak, Chelsey B. Reed, Elizabeth A. Repasky, Bonnie L. Hylander
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)
Background Therapeutic resistance and tumor recurrence are two major hurdles in the treatment of pancreatic ductal adenocarcinoma. Recent findings suggest that both of these attributes are associated with a small subset of pancreatic tumor initiating
Externí odkaz:
https://doaj.org/article/789b054228df43e5ba00b870dbd1141a
Publikováno v:
Sarcoma, Vol 9, Iss 1-2, Pp 25-28 (2005)
Externí odkaz:
https://doaj.org/article/8372c349c1f14979b4eb1e7d4bb1b906
Publikováno v:
Clinical Pharmacokinetics
Introduction Elagolix is approved for the management of moderate-to-severe pain associated with endometriosis. The aim of this analysis was to develop a physiologically based pharmacokinetic (PBPK) model that describes the enzyme-transporter interpla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbca4e35c3d4d7994bdc6b70035aa75
https://doi.org/10.1007/s40262-019-00833-6
https://doi.org/10.1007/s40262-019-00833-6
Autor:
Ransi Somaratne, Ogo Egbuna, Scott M. Wasserman, John P. Gibbs, Lisa Hamilton, Geoffrey A. Block, Edward Lee, Maurice Emery, Patrick Hanafin, Sreeneeranj Kasichayanula
Publikováno v:
Clinical Pharmacology in Drug Development
We evaluated the pharmacokinetics, pharmacodynamics, and safety of evolocumab, a fully human monoclonal antibody against proprotein convertase subtilisin kexin type 9 (PCSK9), in an open‐label, parallel‐design study in participants with normal re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230bf5aeedface69b65f865af0a93b82
https://doi.org/10.1002/cpdd.650
https://doi.org/10.1002/cpdd.650
Publikováno v:
Sarcoma, Vol 6, Iss 2, Pp 69-73 (2002)
Introduction: There is a strong association between poor overall survival and a short disease-free interval for patients with soft tissue sarcomas (STS) and metastatic disease. Patients with STS and synchronous metastases should have a very dismal pr
Externí odkaz:
https://doaj.org/article/8f5c34791c474654ac03cc9723caf2ca
Autor:
Benjamin Cooper, Steven J. Chmura, Jason J. Luke, Stephen L. Shiao, Reva K. Basho, Wade T. Iams, David B. Page, Cong Li, Richard C. Gregory, Michael H. Shaw, Kristin H. Horn, John P. Gibbs, Vicky A. Appleman, Allison J. Berger, Adnan O. Abu-Yousif, Neil B. Lineberry, Kate F. Stumpo, Aymen Elfiky, Naamit K. Gerber
Publikováno v:
Cancer Research. 82:CT243-CT243
Background: Radiation therapy has immune-modulating effects resulting from apoptosis of tumor cells and DNA damage. The downstream generation of cytosolic DNA activates the cyclic GMP-AMP Synthase (cGAS)-STimulator of INterferon Gene (STING) signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f29ad28602a2873546d64c0da4f6f49c
https://doi.org/10.1158/1538-7445.am2022-ct243
https://doi.org/10.1158/1538-7445.am2022-ct243
Autor:
Jennifer R. Diamond, Jason T. Henry, Gerald S. Falchook, Anthony J. Olszanski, Harshabad Singh, E. Jane Leonard, Richard C. Gregory, Vicky A. Appleman, John P. Gibbs, Carole E. Harbison, Cong Li, Jessica M. Sapiro, Tomoki Yoneyama, Alexander Parent, Vincent Chung
Publikováno v:
Cancer Research. 82:CT249-CT249
Background: Although immune checkpoint inhibitors (CPIs) have revolutionized cancer treatment, resistance remains a challenge. Reduced interferon (IFN) signaling, immune escape and immunosuppressive tumor phenotypes have been proposed as resistance m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0443e75639b1a9a5fd592cd0c944ba97
https://doi.org/10.1158/1538-7445.am2022-ct249
https://doi.org/10.1158/1538-7445.am2022-ct249