Zobrazeno 1 - 10
of 33
pro vyhledávání: '"John P. Didion"'
Autor:
Vivek Rai, Daniel X. Quang, Michael R. Erdos, Darren A. Cusanovich, Riza M. Daza, Narisu Narisu, Luli S. Zou, John P. Didion, Yuanfang Guan, Jay Shendure, Stephen C.J. Parker, Francis S. Collins
Publikováno v:
Molecular Metabolism, Vol 32, Iss , Pp 109-121 (2020)
Objective: Type 2 diabetes (T2D) is a complex disease characterized by pancreatic islet dysfunction, insulin resistance, and disruption of blood glucose levels. Genome-wide association studies (GWAS) have identified > 400 independent signals that enc
Externí odkaz:
https://doaj.org/article/0652de6a60844aac846ea57777b9e833
Autor:
Luli S. Zou, Michael R. Erdos, D. Leland Taylor, Peter S. Chines, Arushi Varshney, The McDonnell Genome Institute, Stephen C. J. Parker, Francis S. Collins, John P. Didion
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract Background Bisulfite sequencing is widely employed to study the role of DNA methylation in disease; however, the data suffer from biases due to coverage depth variability. Imputation of methylation values at low-coverage sites may mitigate t
Externí odkaz:
https://doaj.org/article/ca98178c6bb4404ca884764b5ac2aaff
Autor:
Andrew P. Morgan, John P. Didion, Anthony G. Doran, James M. Holt, Leonard McMillan, Thomas M. Keane, Fernando Pardo-Manuel de Villena
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 12, Pp 4211-4216 (2016)
Wild-derived mouse inbred strains are becoming increasingly popular for complex traits analysis, evolutionary studies, and systems genetics. Here, we report the whole-genome sequencing of two wild-derived mouse inbred strains, LEWES/EiJ and ZALENDE/E
Externí odkaz:
https://doaj.org/article/442e37b90d304a4ba8258bbca0866b41
Autor:
Laura J. Scott, Michael R. Erdos, Jeroen R. Huyghe, Ryan P. Welch, Andrew T. Beck, Brooke N. Wolford, Peter S. Chines, John P. Didion, Narisu Narisu, Heather M. Stringham, D. Leland Taylor, Anne U. Jackson, Swarooparani Vadlamudi, Lori L. Bonnycastle, Leena Kinnunen, Jouko Saramies, Jouko Sundvall, Ricardo D'Oliveira Albanus, Anna Kiseleva, John Hensley, Gregory E. Crawford, Hui Jiang, Xiaoquan Wen, Richard M. Watanabe, Timo A. Lakka, Karen L. Mohlke, Markku Laakso, Jaakko Tuomilehto, Heikki A. Koistinen, Michael Boehnke, Francis S. Collins, Stephen C. J. Parker
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
More than 90% of genetic variants associated with type 2 diabetes occur in non-coding regions. Scott et al. report genomes, epigenomes and transcriptomes of skeletal muscle from 271 participants with a range of glucose tolerances, revealing a genetic
Externí odkaz:
https://doaj.org/article/05b203e73f38446db6c6345b6a617738
Autor:
Andrew P. Morgan, Chen-Ping Fu, Chia-Yu Kao, Catherine E. Welsh, John P. Didion, Liran Yadgary, Leeanna Hyacinth, Martin T. Ferris, Timothy A. Bell, Darla R. Miller, Paola Giusti-Rodriguez, Randal J. Nonneman, Kevin D. Cook, Jason K. Whitmire, Lisa E. Gralinski, Mark Keller, Alan D. Attie, Gary A. Churchill, Petko Petkov, Patrick F. Sullivan, Jennifer R. Brennan, Leonard McMillan, Fernando Pardo-Manuel de Villena
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 2, Pp 263-279 (2016)
Genotyping microarrays are an important resource for genetic mapping, population genetics, and monitoring of the genetic integrity of laboratory stocks. We have developed the third generation of the Mouse Universal Genotyping Array (MUGA) series, Gig
Externí odkaz:
https://doaj.org/article/7b77e12c8fb14a99aaee429fcfb94338
Publikováno v:
PeerJ, Vol 5, p e3720 (2017)
A key step in the transformation of raw sequencing reads into biological insights is the trimming of adapter sequences and low-quality bases. Read trimming has been shown to increase the quality and reliability while decreasing the computational requ
Externí odkaz:
https://doaj.org/article/832121f4da64461b9e97875c7b8a4e6e
Autor:
Fernando Pardo-Manuel de Villena, Amelia M.-F. Clayshulte, Liran Yadgary, John P. Didion, Duncan T. Odom, Andrew P. Morgan, Leonard McMillan, Rachel C. McMullan, James Holt, Paul Flicek, Timothy A. Bell, David Thybert
Gene duplication and loss are major sources of genetic polymorphism in populations, and are important forces shaping the evolution of genome content and organization. We have reconstructed the origin and history of a 127 kbp segmental duplication,R2d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a327bcf44a31d9a98fe3a0abc555c570
Population structure and inbreeding in wild house mice (Mus musculus) at different geographic scales
Autor:
Andrew P. Morgan, Jonathan J. Hughes, John P. Didion, Wesley J. Jolley, Karl J. Campbell, David W. Threadgill, Francois Bonhomme, Jeremy B. Searle, Fernando Pardo-Manuel de Villena
Publikováno v:
Heredity. 129(3)
House mice (Mus musculus) have spread globally as a result of their commensal relationship with humans. In the form of laboratory strains, both inbred and outbred, they are also among the most widely used model organisms in biomedical research. Altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6a048a443176243e46412ec4b7f290
https://pubmed.ncbi.nlm.nih.gov/35764696
https://pubmed.ncbi.nlm.nih.gov/35764696
Population structure and inbreeding in wild house mice (Mus musculus) at different geographic scales
Autor:
Andrew P Morgan, Jonathan J Hughes, John P Didion, Wesley J Jolley, Karl J Campbell, David W Threadgill, Francois Bonhomme, Jeremy B Searle, Fernando Pardo-Manuel de Villena
House mice (Mus musculus) have spread globally as a result of their commensal relationship with humans. In the form of laboratory strains, both inbred and outbred, they are also among the most widely-used model organisms in biomedical research. Altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3981d016dee42a604f47fce7a28df3ae
https://doi.org/10.1101/2022.02.17.478179
https://doi.org/10.1101/2022.02.17.478179
Autor:
Sirintorn Stantripop, Sean Black, Ricardo D’Oliveira Albanus, S. L. Ho, John P. Didion, Beatrice B. Barnabas, Francis S. Collins, Brian P. Schmidt, Peter Orchard, Quino Maduro, Casandra Montemayor, Christina Sison, Karen L. Mohlke, Hannah J Perrin, K. Alaine Broadaway, Alice C. Young, Juyun Kim, Morgan Park, Laura J. Scott, Swarooparani Vadlamudi, Erin G. Schuetz, Karen Schandler, Narisu Narisu, James W. Thomas, Richelle Legaspi, Shelise Brooks, Gerard G. Bouffard, Joel Han, Federico Innocenti, Nancy Riebow, Vivek Rai, Lyudmila Dekhtyar, James C. Mullikin, Stephen C. J. Parker, Michael R. Erdos, Holly Coleman, Tingfen Yan, Catherine A. Masiello, Lori L. Bonnycastle, Jacqueline R. Idol, Amarjit S. Chaudhry, Jennifer C. McDowell, Kevin W Currin, Meghana Vemulapalli, Pamela J. Thomas, Amy S. Etheridge
Publikováno v:
Am J Hum Genet
Identifying the molecular mechanisms by which genome-wide association study (GWAS) loci influence traits remains challenging. Chromatin accessibility quantitative trait loci (caQTLs) help identify GWAS loci that may alter GWAS traits by modulating ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bebdd55fe1d80ed53db25b6e571c5a0
https://pubmed.ncbi.nlm.nih.gov/34038741
https://pubmed.ncbi.nlm.nih.gov/34038741