Zobrazeno 1 - 10
of 115
pro vyhledávání: '"John P. Dekker"'
Autor:
Augusto Dulanto Chiang, John P. Dekker
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-9 (2024)
Abstract The emergence and spread of bacteria resistant to commonly used antibiotics poses a critical threat to modern medical practice. Multiple classes of bacterial efflux pump systems play various roles in antibiotic resistance, and members of the
Externí odkaz:
https://doaj.org/article/e92d08fa141d42ea8fec5473e75d9d96
Autor:
Ousmane H. Cissé, Shelly J. Curran, H. Diego Folco, Yueqin Liu, Lisa Bishop, Honghui Wang, Elizabeth R. Fischer, A. Sally Davis, Christian Combs, Sabrina Thapar, John P. Dekker, Shiv Grewal, Melanie Cushion, Liang Ma, Joseph A. Kovacs
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Centromeres are constricted chromosomal regions that are essential for cell division. In eukaryotes, centromeres display a remarkable architectural and genetic diversity. The basis of centromere-accelerated evolution remains elusive. Here, w
Externí odkaz:
https://doaj.org/article/b90416d035844a13812402c4d792a37f
Autor:
Michael J. Tisza, Derek D. N. Smith, Andrew E. Clark, Jung-Ho Youn, NISC Comparative Sequencing Program, Pavel P. Khil, John P. Dekker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Three types of DNA methyl modifications have been detected in bacterial genomes, and mechanistic studies have demonstrated roles for DNA methylation in physiological functions ranging from phage defense to transcriptional control of virulenc
Externí odkaz:
https://doaj.org/article/42edacfce32b47419fe04b5eefbd110a
Autor:
Ousmane H. Cissé, Liang Ma, John P. Dekker, Pavel P. Khil, Jung-Ho Youn, Jason M. Brenchley, Robert Blair, Bapi Pahar, Magali Chabé, Koen K. A. Van Rompay, Rebekah Keesler, Antti Sukura, Vanessa Hirsch, Geetha Kutty, Yueqin Liu, Li Peng, Jie Chen, Jun Song, Christiane Weissenbacher-Lang, Jie Xu, Nathan S. Upham, Jason E. Stajich, Christina A. Cuomo, Melanie T. Cushion, Joseph A. Kovacs
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Cissé, Ma et al. utilize genomic data from Pneumocystis species infecting macaques, rabbit, dogs and rats to investigate the molecular basis of host specificity in Pneumocystis. Their analyses provide insight to the specific adaptations enabling the
Externí odkaz:
https://doaj.org/article/907c65fcc47a4c35b7cdbbac023e26da
Autor:
Honghui Wang, Yong Chen, Jeffrey R. Strich, Steven K. Drake, Jung-Ho Youn, Avi Z. Rosenberg, Marjan Gucek, Patrick T. McGann, Anthony F. Suffredini, John P. Dekker
Publikováno v:
Clinical Proteomics, Vol 16, Iss 1, Pp 1-10 (2019)
Abstract Background Colistin (polymyxin E) and polymixin B are important bactericidal antibiotics used in the treatment of serious infections caused by multi-drug resistant Gram-negative organisms. Transferrable plasmid-mediated colistin resistance,
Externí odkaz:
https://doaj.org/article/4331f9a41a214da3b0c2055a8a84357e
Autor:
Honghui Wang, Steven K. Drake, Jung-Ho Youn, Avi Z. Rosenberg, Yong Chen, Marjan Gucek, Anthony F. Suffredini, John P. Dekker
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Carbapenemase producing organisms (CPOs) represent an urgent public health threat, and the need for new rapid methods to detect these organisms has been widely recognized. CPOs carrying the Klebsiella pneumoniae carbapenemase (bla KPC ) gene
Externí odkaz:
https://doaj.org/article/0818e8dae94e4d92bda5bd76772b5d1e
Autor:
Sean Conlan, Anna F. Lau, Clay Deming, Christine D. Spalding, ShihQueen Lee-Lin, Pamela J. Thomas, Morgan Park, John P. Dekker, Karen M. Frank, Tara N. Palmore, Julia A. Segre
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Antibiotics, which are used both to prevent and to treat infections, are a mainstay therapy for lifesaving procedures such as transplantation. For this reason, and many others, increased antibiotic resistance among human-associated pathogens
Externí odkaz:
https://doaj.org/article/43d2293eef194b7a9a9cfe66420d1727
Autor:
Pavel P. Khil, Augusto Dulanto Chiang, Jonathan Ho, Jung-Ho Youn, Jamie K. Lemon, Juan Gea-Banacloche, Karen M. Frank, Mark Parta, Robert A. Bonomo, John P. Dekker
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Strains of Pseudomonas aeruginosa with deficiencies in DNA mismatch repair have been studied in the context of chronic infection, where elevated mutational rates (“hypermutation”) may facilitate the acquisition of antimicrobial resistanc
Externí odkaz:
https://doaj.org/article/7f73195dff6c40008b4e1528001c23e0
Autor:
Melissa D. Barnes, Magdalena A. Taracila, Joseph D. Rutter, Christopher R. Bethel, Ioannis Galdadas, Andrea M. Hujer, Emilia Caselli, Fabio Prati, John P. Dekker, Krisztina M. Papp-Wallace, Shozeb Haider, Robert A. Bonomo
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Pseudomonas aeruginosa produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam an
Externí odkaz:
https://doaj.org/article/edb8dbd7a6454ff080c0150b5085a0a8
Autor:
Ousmane H. Cissé, Liang Ma, Da Wei Huang, Pavel P. Khil, John P. Dekker, Geetha Kutty, Lisa Bishop, Yueqin Liu, Xilong Deng, Philippe M. Hauser, Marco Pagni, Vanessa Hirsch, Richard A. Lempicki, Jason E. Stajich, Christina A. Cuomo, Joseph A. Kovacs
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT Pneumocystis species are opportunistic mammalian pathogens that cause severe pneumonia in immunocompromised individuals. These fungi are highly host specific and uncultivable in vitro. Human Pneumocystis infections present major challenges b
Externí odkaz:
https://doaj.org/article/c0995cfe69d144e9b577c9ecad070400