Zobrazeno 1 - 10
of 383
pro vyhledávání: '"John P. Connolly"'
Autor:
Sudha R. Raman, Bradley G. Hammill, Pamela A. Shaw, Hana Lee, Sengwee Toh, John G. Connolly, Kimberly J. Dandreo, Vinit Nalawade, Fang Tian, Wei Liu, Jie Li, José J. Hernández-Muñoz, Robert J. Glynn, Rishi J. Desai, Janick Weberpals
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Missing data in confounding variables present a frequent challenge in generating evidence using real-world data, including electronic health records (EHR). Our objective was to apply a recently published toolkit for characterizing
Externí odkaz:
https://doaj.org/article/4ae0b29ad6134def83c0064c37302018
Autor:
John B. Connolly, Austin Burt, George Christophides, Abdoulaye Diabate, Tibebu Habtewold, Penelope A. Hancock, Anthony A. James, Jonathan K. Kayondo, Dickson Wilson Lwetoijera, Alphaxard Manjurano, Andrew R. McKemey, Michael R. Santos, Nikolai Windbichler, Filippo Randazzo
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Sustainable reductions in African malaria transmission require innovative tools for mosquito control. One proposal involves the use of low-threshold gene drive in Anopheles vector species, where a ‘causal pathway’ would be initiated by (
Externí odkaz:
https://doaj.org/article/b6a7d6d5b26e4dd49ad7b5d50b906a08
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
BackgroundPhotorhabdus asymbiotica is a species of the insect pathogenic Photorhabdus genus that has been isolated as an etiological agent in human infections. Since then, multiple isolates have been identified worldwide; however, actual clinical inf
Externí odkaz:
https://doaj.org/article/d6b75e437b804be99f03cac5d388e3e1
Autor:
Kathleen Ferar, Taryn O. Hall, Dana C. Crawford, Robb Rowley, Benjamin A. Satterfield, Rongling Li, Loren Gragert, Elizabeth W. Karlson, Mariza de Andrade, Iftikhar J. Kullo, Catherine A. McCarty, Abel Kho, M. Geoffrey Hayes, Marylyn D. Ritchie, Paul K. Crane, Daniel B. Mirel, Christopher Carlson, John J. Connolly, Hakon Hakonarson, Andrew T. Crenshaw, David Carrell, Yuan Luo, Ozan Dikilitas, Joshua C. Denny, Gail P. Jarvik, David R. Crosslin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Clostridioides difficile (C. diff.) infection (CDI) is a leading cause of hospital acquired diarrhea in North America and Europe and a major cause of morbidity and mortality. Known risk factors do not fully explain CDI susceptibility, and ge
Externí odkaz:
https://doaj.org/article/458631016886416d88885a8ac733ac36
Autor:
John B. Connolly, Austin Burt, George Christophides, Abdoulaye Diabate, Tibebu Habtewold, Penelope A. Hancock, Anthony A. James, Jonathan K. Kayondo, Dickson Wilson Lwetoijera, Alphaxard Manjurano, Andrew R. McKemey, Michael R. Santos, Nikolai Windbichler, Filippo Randazzo
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e19f7e65e26e404484000c0275840909
Autor:
Alima Qureshi, John B. Connolly
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-28 (2023)
Abstract Background Population suppression gene drive is currently being evaluated, including via environmental risk assessment (ERA), for malaria vector control. One such gene drive involves the dsxF CRISPRh transgene encoding (i) hCas9 endonuclease
Externí odkaz:
https://doaj.org/article/a39d3059b214412087e3b7db1bfd661c
Autor:
Sven H. Petersen, Kays Al Badawy, Richard Hopkins, Dang L. Vu, Mehran Rahmani, Sonia M.P. Maia, John E. Connolly
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100730- (2023)
Transforming growth factor β (TGF-β) is a pleiotropic cytokine expressed by a wide range of cell types and is known for hampering the effectiveness of cancer immune cell therapeutic approaches. We have designed a novel construct containing the extr
Externí odkaz:
https://doaj.org/article/83027325b8ec46cd8570a044c90ebe39
Autor:
Tira J. Tan, W. X. Gladys Ang, Who-Whong Wang, Hui-Shan Chong, Sze Huey Tan, Rachael Cheong, John Whay-Kuang Chia, Nicholas L. Syn, Wai Ho Shuen, Rebecca Ba, Nivashini Kaliaperumal, Bijin Au, Richard Hopkins, Xinhua Li, Aaron C. Tan, Amanda O. L. Seet, John E. Connolly, Thaschawee Arkachaisri, Valerie Chew, Ahmad bin Mohamed Lajam, Dianyan Guo, Marvin Z. W. Chew, Martin Wasser, Pavanish Kumar, Salvatore Albani, Han Chong Toh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Ad-sig-hMUC1/ecdCD40L is a recombinant adenovirus vaccine comprising human MUC1 antigen fused to the extracellular domain of the CD40 ligand. Here the authors report the result of a phase I clinical trial of Ad-sig-hMUC1/ecdCD40L in patients with adv
Externí odkaz:
https://doaj.org/article/bc9966f3f06642699fbd9cc02be4f7e3
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 4, Pp n/a-n/a (2023)
Abstract Background Obesity is a complex trait caused by a combination of genetic, environmental and lifestyle factors that contributes to the risks of numerous serious diseases. Predictive measures of body mass index (BMI) hold significant promise,
Externí odkaz:
https://doaj.org/article/da118f66772e43b79297db9d5198e7c2
Autor:
Sean Hennessy, Rebecca A Hubbard, Vincent Lo Re, Dena M Carbonari, Claudia A Steiner, Yunping Zhou, Cheryl N McMahill-Walraven, Pamala A Pawloski, Laura Hou, Sarah K Dutcher, John G Connolly, Silvia Perez-Vilar, Terese A DeFor, Djeneba Audrey Djibo, Laura B Harrington, Maria E Kempner, Jennifer L Kuntz, Jolene Mosley, Andrew B Petrone, Allyson M Pishko, Meighan Rogers Driscoll, Noelle M Cocoros
Publikováno v:
BMJ Medicine, Vol 2, Iss 1 (2023)
Objective To measure the 90 day risk of arterial thromboembolism and venous thromboembolism among patients diagnosed with covid-19 in the ambulatory (ie, outpatient, emergency department, or institutional) setting during periods before and during cov
Externí odkaz:
https://doaj.org/article/2491d0112e4f451494c117e8637225d9