Zobrazeno 1 - 10
of 242
pro vyhledávání: '"John P. Clancy"'
Autor:
Theodore G. Liou, Natalia Argel, Fadi Asfour, Perry S. Brown, Barbara A. Chatfield, David R. Cox, Cori L. Daines, Dixie Durham, Jessica A. Francis, Barbara Glover, My Helms, Theresa Heynekamp, John R. Hoidal, Judy L. Jensen, Christiana Kartsonaki, Ruth Keogh, Carol M. Kopecky, Noah Lechtzin, Yanping Li, Jerimiah Lysinger, Osmara Molina, Craig Nakamura, Kristyn A. Packer, Robert Paine, III, Katie R. Poch, Alexandra L. Quittner, Peggy Radford, Abby J. Redway, Scott D. Sagel, Rhonda D. Szczesniak, Shawna Sprandel, Jennifer L. Taylor-Cousar, Jane B. Vroom, Ryan Yoshikawa, John P. Clancy, J. Stuart Elborn, Kenneth N. Olivier, Frederick R. Adler
Publikováno v:
iScience, Vol 27, Iss 3, Pp 108835- (2024)
Summary: Airway inflammation underlies cystic fibrosis (CF) pulmonary exacerbations. In a prospective multicenter study of randomly selected, clinically stable adolescents and adults, we assessed relationships between 24 inflammation-associated molec
Externí odkaz:
https://doaj.org/article/0b6e6acfca2f4e87b4dbc09bc0ef7656
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background The primary underlying defect in cystic fibrosis (CF) is disrupted ion transport in epithelia throughout the body. It is unclear if symptoms such as airway hyperreactivity (AHR) and increased airway smooth muscle (ASM) volume in p
Externí odkaz:
https://doaj.org/article/23acaf1ad9184159a7745faeb2dda18e
Autor:
Anushka K. Palipana, Andrew Vancil, Emrah Gecili, Erika Rasnick, Daniel Ehrlich, Teresa Pestian, Eleni-Rosalina Andrinopoulou, Pedro M. Afonso, Ruth H. Keogh, Yizhao Ni, Judith W. Dexheimer, John P. Clancy, Patrick Ryan, Cole Brokamp, Rhonda D. Szczesniak
Publikováno v:
Environmental Advances, Vol 14, Iss , Pp 100449- (2023)
Background: Cystic fibrosis (CF) is a genetic disease but is greatly impacted by non-genetic (social/environmental and stochastic) influences. Some people with CF experience rapid decline, a precipitous drop in lung function relative to patient- and/
Externí odkaz:
https://doaj.org/article/4d1ca29457fc4bd1b63cb08ea44ca047
Autor:
David P. Nichols, Sarah J. Morgan, Michelle Skalland, Anh T. Vo, Jill M. Van Dalfsen, Sachinkumar B.P. Singh, Wendy Ni, Lucas R. Hoffman, Kailee McGeer, Sonya L. Heltshe, John P. Clancy, Steven M. Rowe, Peter Jorth, Pradeep K. Singh, the PROMISE-Micro Study Group
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)
Background Lung infections are among the most consequential manifestations of cystic fibrosis (CF) and are associated with reduced lung function and shortened survival. Drugs called CF transmembrane conductance regulator (CFTR) modulators improve act
Externí odkaz:
https://doaj.org/article/f38c402d2a6340749497b7d56e6094d6
Autor:
Rhonda D. Szczesniak, Teresa Pestian, Leo L. Duan, Dan Li, Sophia Stamper, Brycen Ferrara, Elizabeth Kramer, John P. Clancy, Daniel Grossoehme
Publikováno v:
BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Beginning at a young age, children with cystic fibrosis (CF) embark on demanding care regimens that pose challenges to parents. We examined the extent to which clinical, demographic and psychosocial features inform patterns of adh
Externí odkaz:
https://doaj.org/article/64285904fcbd4352b0c8c4c4b6c7d316
Autor:
Galit Livnat, Jessica D. Meeker, Alicia J. Ostmann, Lauren M. Strecker, John P. Clancy, John J. Brewington
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1246 (2023)
Cystic Fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), a chloride/bicarbonate channel. Many studies utilize human airway cell models (cell lines and primary cells) to study different aspects of CFTR biology.
Externí odkaz:
https://doaj.org/article/347effde1cc14b6f8b399e748056b318
Autor:
Theodore G. Liou, Frederick R. Adler, Natalia Argel, Fadi Asfour, Perry S. Brown, Barbara A. Chatfield, Cori L. Daines, Dixie Durham, Jessica A. Francis, Barbara Glover, Theresa Heynekamp, John R. Hoidal, Judy L. Jensen, Ruth Keogh, Carol M. Kopecky, Noah Lechtzin, Yanping Li, Jerimiah Lysinger, Osmara Molina, Craig Nakamura, Kristyn A. Packer, Katie R. Poch, Alexandra L. Quittner, Peggy Radford, Abby J. Redway, Scott D. Sagel, Shawna Sprandel, Jennifer L. Taylor-Cousar, Jane B. Vroom, Ryan Yoshikawa, John P. Clancy, J. Stuart Elborn, Kenneth N. Olivier, David R. Cox
Publikováno v:
BMC Medical Research Methodology, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background Biomarkers of inflammation predictive of cystic fibrosis (CF) disease outcomes would increase the power of clinical trials and contribute to better personalization of clinical assessments. A representative patient cohort would imp
Externí odkaz:
https://doaj.org/article/cdeb10f8f67f4a68b3449c8f95764544
Publikováno v:
IEEE Journal of Translational Engineering in Health and Medicine, Vol 7, Pp 1-8 (2019)
The clinical course of cystic fibrosis (CF) lung disease is marked by acute drops of lung function, defined clinically as rapid decline. As such, lung function is monitored routinely through pulmonary function testing, producing hundreds of measureme
Externí odkaz:
https://doaj.org/article/112006e62b0a439fb46bb46aa8b151aa
Seasonality, mediation and comparison (SMAC) methods to identify influences on lung function decline
Autor:
Emrah Gecili, Anushka Palipana, Cole Brokamp, Rui Huang, Eleni-Rosalina Andrinopoulou, Teresa Pestian, Erika Rasnick, Ruth H. Keogh, Yizhao Ni, John P. Clancy, Patrick Ryan, Rhonda D. Szczesniak
Publikováno v:
MethodsX, Vol 8, Iss , Pp 101313- (2021)
This study develops a comprehensive method to assess seasonal influences on a longitudinal marker and compare estimates between cohorts. The method extends existing approaches by (i) combining a sine-cosine model of seasonality with a specialized cov
Externí odkaz:
https://doaj.org/article/18b93bdee9c949028ed4c9b86d184a64
Publikováno v:
Emerging Themes in Epidemiology, Vol 14, Iss 1, Pp 1-13 (2017)
Abstract Background Epidemiologic surveillance of lung function is key to clinical care of individuals with cystic fibrosis, but lung function decline is nonlinear and often impacted by acute respiratory events known as pulmonary exacerbations. Stati
Externí odkaz:
https://doaj.org/article/70a02b184e6d4e0ba906d6c689504826