Zobrazeno 1 - 5
of 5
pro vyhledávání: '"John P. Busanovich"'
Autor:
Caitlin A. Nichols, William J. Gibson, Meredith S. Brown, Jack A. Kosmicki, John P. Busanovich, Hope Wei, Laura M. Urbanski, Naomi Curimjee, Ashton C. Berger, Galen F. Gao, Andrew D. Cherniack, Sirano Dhe-Paganon, Brenton R. Paolella, Rameen Beroukhim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
In tumors, hundreds of genes can undergo loss of heterozygosity (LOH). Here, the authors investigate the potential for this LOH as a class of non-driver cancer vulnerabilities.
Externí odkaz:
https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e0
Autor:
Narmen Azazmeh, Cecile Rouleau, Kate Schoolcraft, Etai Jacob, Seth Malinowski, John P Busanovich, Lori Ramkissoon, Yun Jee Kang, Shakti Ramkissoon, Kristine Pelton, Alice Meng, Victor Jones, Rodderick Bronson, Federica Piccioni, Claudia Kleinman, Pratiti Bandopadhayay, Keith Ligon, Rameen Beroukhim
Publikováno v:
Neuro-Oncology. 24:vii299-vii299
Low-grade gliomas (LGG) represent 30% of pediatric brain tumors. Their cellular origins are unknown but are presumed to arise from subtle alterations of progenitor cell cycle regulation during brain development. Rearrangements activating MYB and MYBL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52557d54b4c171d22cbf759c86844a1b
https://doi.org/10.1093/neuonc/noac209.1165
https://doi.org/10.1093/neuonc/noac209.1165
Autor:
Ashton C. Berger, John P. Busanovich, Naomi Curimjee, Hope Wei, Sirano Dhe-Paganon, Jack A. Kosmicki, Meredith S. Brown, Andrew D. Cherniack, Rameen Beroukhim, Galen F. Gao, Brenton R. Paolella, Caitlin A. Nichols, Laura M. Urbanski, William J. Gibson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Alterations in non-driver genes represent an emerging class of potential therapeutic targets in cancer. Hundreds to thousands of non-driver genes undergo loss of heterozygosity (LOH) events per tumor, generating discrete differences between tumor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69932bff7bf9743b48a41cd448c169c1
https://doi.org/10.1038/s41467-020-16399-y
https://doi.org/10.1038/s41467-020-16399-y
Autor:
Rameen Beroukhim, Nicholas L. Truex, Alexander R. Loftis, Xiaoli Liao, Bradley L. Pentelute, Zeyu Lu, Amy E. Rabideau, Meredith Brown, Brenton R. Paolella, John P. Busanovich
Publikováno v:
ACS Chem Biol
PMC
PMC
Copyright © 2020 American Chemical Society. Antisense oligonucleotide therapies are important cancer treatments, which can suppress genes in cancer cells that are critical for cell survival. SF3B1 has recently emerged as a promising gene target that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a52d3838b90588ed89d9b34e76fcc89
https://pubmed.ncbi.nlm.nih.gov/32348107
https://pubmed.ncbi.nlm.nih.gov/32348107
Autor:
Meredith Brown, Brenton R. Paolella, Laura M. Urbanski, Ashton C. Berger, Caitlin A. Nichols, Jack A. Kosmicki, John P. Busanovich, William J. Gibson, Galen F. Gao, Andrew D. Cherniack, Rameen Beroukhim
Publikováno v:
Cancer Research. 78:3003-3003
Despite progress in precision cancer drug discovery, few highly selective therapies exist in the clinic, creating the need for additional therapeutic targets. We have shown that copy number alterations (CNAs) in essential genes represent novel non-dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9f6b2bf8cc168822555e55e0285d300
https://doi.org/10.1158/1538-7445.am2018-3003
https://doi.org/10.1158/1538-7445.am2018-3003