Zobrazeno 1 - 10
of 142
pro vyhledávání: '"John P. Adams"'
Autor:
Azhar Muneer, Swamy R. Adapa, Suzane Silbert, Kelly Scanlan, Harold Vore, Andrew Cannons, Andrea M. Morrison, Danielle Stanek, Carina Blackmore, John H. Adams, Kami Kim, Rays H.Y. Jiang, Liwang Cui
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 6, Pp 1214-1217 (2024)
During May–July 2023, a cluster of 7 patients at local hospitals in Florida, USA, received a diagnosis of Plasmodium vivax malaria. Whole-genome sequencing of the organism from 4 patients and phylogenetic analysis with worldwide representative P. v
Externí odkaz:
https://doaj.org/article/5eeae53dd91f43778ec4357fefe0d3b4
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 12, Iss 3 (2024)
Introduction Studies have found that sodium-glucose cotransporter 2 inhibitors (SGLT2) and glucagon-like peptide 1 receptor agonists (GLP1) have cardiovascular benefits for patients with type 2 diabetes (DM2) and atherosclerotic cardiovascular diseas
Externí odkaz:
https://doaj.org/article/987590951e154166aef6f5dcb719c0b7
Autor:
Francis Babila Ntumngia, Surendra Kumar Kolli, Pradeep Annamalai Subramani, Samantha J. Barnes, Justin Nicholas, Madison M. Ogbondah, Brian B. Barnes, Nichole D. Salinas, Pongsakorn Thawornpan, Niraj H. Tolia, Patchanee Chootong, John H. Adams
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract In Plasmodium vivax, the most studied vaccine antigens are aimed at blocking merozoite invasion of erythrocytes and disease development. Very few studies have evaluated pre-erythrocytic (PE) stage antigens. The P. vivax circumsporozoite prot
Externí odkaz:
https://doaj.org/article/d14402fce10d475e9b4b167329817cb1
Autor:
Camilla Valente Pires, Debora Cassandra, Shulin Xu, Benoit Laleu, Jeremy N. Burrows, John H. Adams
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Malaria parasites have adaptive mechanisms to modulate their intracellular redox status to tolerate the enhanced oxidizing effects created by malaria fever, hemoglobinopathies and other stress conditions, including antimalaria drugs. Emergin
Externí odkaz:
https://doaj.org/article/76188a7284fa440fbb34f23d01b7d90d
Autor:
Justin Nicholas, Surendra Kumar Kolli, Pradeep Annamalai Subramani, Sai Lata De, Madison M. Ogbondah, Samantha J. Barnes, Francis Babila Ntumngia, John H. Adams
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-10 (2023)
Abstract Background Acquired functional inhibitory antibodies are one of several humoral immune mechanisms used to neutralize foreign pathogens. In vitro bioassays are useful tools for quantifying antibody-mediated inhibition and evaluating anti-para
Externí odkaz:
https://doaj.org/article/ef907aea9d314903925099b669db0dc3
Autor:
Chengqi Wang, Yibo Dong, Chang Li, Jenna Oberstaller, Min Zhang, Justin Gibbons, Camilla Valente Pires, Mianli Xiao, Lei Zhu, Rays H. Y. Jiang, Kami Kim, Jun Miao, Thomas D. Otto, Liwang Cui, John H. Adams, Xiaoming Liu
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Malaria remains one of the deadliest infectious diseases. Transcriptional regulation effects of noncoding variants in this unusual genome of malaria parasites remain elusive. We developed a sequence-based, ab initio deep learning framework,
Externí odkaz:
https://doaj.org/article/004e37fc75b5456aa0afc0c9d7b5baaa
Autor:
Pongsakorn Thawornpan, Justin Nicholas, Chayapat Malee, Piyawan Kochayoo, Kittikorn Wangriatisak, Pachara Tianpothong, Francis Babila Ntumngia, Samantha J Barnes, John H Adams, Patchanee Chootong
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 1, p e0011907 (2024)
BackgroundP. vivax malaria is a major global health burden hindering social and economic development throughout many tropical and sub-tropical countries. Pre-erythrocytic (PE) vaccines emerge as an attractive approach for the control and elimination
Externí odkaz:
https://doaj.org/article/edfec4a9ede647b7a2ac5009c59cdb72
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-17 (2023)
Abstract Background Knowledge of the diversity of invasion ligands in malaria parasites in endemic regions is essential to understand how natural selection influences genetic diversity of these ligands and their feasibility as possible targets for fu
Externí odkaz:
https://doaj.org/article/1a565ca9439b4b9ab56d7fcf965869ca
Autor:
Pongsakorn Thawornpan, Chayapat Malee, Piyawan Kochayoo, Kittikorn Wangriatisak, Chaniya Leepiyasakulchai, Francis B. Ntumngia, Sai Lata De, John H. Adams, Patchanee Chootong
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Plasmodium vivax Duffy Binding Protein region II (PvDBPII) is a leading vaccine candidate against blood-stage vivax malaria. Anti-PvDBPII antibodies potentially block parasite invasion by inhibition of erythrocyte binding. However, knowledge
Externí odkaz:
https://doaj.org/article/5fb7b50a80ce45fbb6b781a5de8698fd
Autor:
Natthida Sriboonvorakul, Kesinee Chotivanich, Udomsak Silachamroon, Weerapong Phumratanaprapin, John H Adams, Arjen M Dondorp, Stije J Leopold
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011661 (2023)
The pathophysiology of severe falciparum malaria involves a complex interaction between the host, parasite, and gut microbes. In this review, we focus on understanding parasite-induced intestinal injury and changes in the human intestinal microbiota
Externí odkaz:
https://doaj.org/article/5c9d0d0d8038496e8a143bb028340b02