Zobrazeno 1 - 10
of 47
pro vyhledávání: '"John P. Felix"'
Publikováno v:
Journal of Clinical and Diagnostic Research, Vol 16, Iss 11, Pp YC01-YC04 (2022)
Introduction: Most of the Chronic Obstructive Pulmonary Disease (COPD) patients are smokers and their disease progresses with increasing age. The energy cost of walking has strong association with aging and cigarette smoking. Its implication in COPD
Externí odkaz:
https://doaj.org/article/cf35a9651f8445608ebe2af2f1882a03
Publikováno v:
Dental Research Journal, Vol 15, Iss 4, Pp 231-241 (2018)
Background: Various nonsurgical interventions have been used for the management of patients with temporomandibular joint (TMJ) disorders, but their clinical effectiveness remains unclear. Hence, the purpose of this systematic review and meta-analyses
Externí odkaz:
https://doaj.org/article/3679db0e80154a25afa5068620bddfe7
Publikováno v:
Journal of Clinical and Diagnostic Research, Vol 13, Iss 7, Pp DC01-DC06 (2019)
Introduction: Reduced susceptibility of carbapenems against enterobacterial strains have emerged as an important public health problem worldwide. Infection caused by Carbapenem Resistant Enterobacteriaceae (CRE) can affect severely ill patients, and
Externí odkaz:
https://doaj.org/article/bbdf40802abd40c7885568e7022110ae
Publikováno v:
The Scientific World Journal, Vol 4, Pp 1046-1054 (2004)
Recently, free radicalinduced tissue damage is implicated in the nonsteroidal anti-inflammatory drugs (NSAIDs)involved gastric mucosal lesion. Administration of taurine, an endogenous antioxidant, is reported to be beneficial in various clinical cond
Externí odkaz:
https://doaj.org/article/c34aff89857d4290aba8c2ce762a91c5
Autor:
Lee-Yuh Pai, Aaron Corona, Harry R. Chobanian, John P. Felix, Matthew J. Clements, Karen Owens, Haifeng Tang, Brande Thomas-Fowlkes, Kathleen A. Sullivan, Alexander Pasternak, Caryn Hampton, Jessica Frie, Vincent Tong, Ron Ferguson, Jessica Liu, Birgit T. Priest, Barbara Pio, Yan Guo, Elizabeth Joshi, Nardos Teumelsan, Ling Xu, Martin Köhler, Joseph M. Metzger, Zach Guo, Kevin M. Maloney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1109-1114
A spirocyclic class of ROMK inhibitors was developed containing a structurally diverse heterocyclic sulfone moiety and spirocyclic core starting from lead 1. These compounds not only displayed exquisite ROMK potency but significantly improved selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c5ab8a2efa0d6babaaad56a9277a67
https://doi.org/10.1016/j.bmcl.2016.10.032
https://doi.org/10.1016/j.bmcl.2016.10.032
Autor:
Shawn P. Walsh, Lee-Yuh Pai, Yuping Zhu, John P. Felix, Caryn Hampton, Xiaoyan Zhou, Melba Hernandez, Brande Thomas-Fowlkes, Richard M. Brochu, Nardos Teumelsan, Gregory J. Kaczorowski, Emma R. Parmee, Maria L. Garcia, Alexander Pasternak, Jinlong Jiang, Sookhee Ha, Sophie Roy, Kathleen A. Sullivan, Haifeng Tang, Lihu Yang, Karen Owens, Reynalda K. de Jesus, Xin Gu, Birgit T. Priest, Barbara Pio, Fa-Xiang Ding, Andrew M. Swensen, Magdalena Alonso-Galicia, Aurash Shahripour, Juliann Ehrhart, Timothy Bailey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5695-5702
Following the discovery of small molecule acyl piperazine ROMK inhibitors, the acyl octahydropyrazino[2,1-c][1,4]oxazine series was identified. This series displays improved ROMK/hERG selectivity, and as a consequence, the resulting ROMK inhibitors d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ba115f699ab80f9a1176691245bcc
https://doi.org/10.1016/j.bmcl.2016.10.064
https://doi.org/10.1016/j.bmcl.2016.10.064
Autor:
Michael J. Forrest, John P. Felix, Lee-Yuh Pai, Melba Hernandez, Yuping Zhu, Aaron Corona, Joseph M. Metzger, Gregory J. Kaczorowski, Nardos Teumelsan, Lihu Yang, Karen Owens, Timothy Bailey, Caryn Hampton, Vincent Tong, Alexander Pasternak, Brande Thomas-Fowlkes, Shawn P. Walsh, Emma R. Parmee, Haifeng Tang, Richard M. Brochu, Maria L. Garcia, Xiaoyan Zhou, Magdalena Alonso-Galicia, Sophie Roy, Birgit T. Priest, Andrew M. Swensen, Aurash Shahripour
Publikováno v:
ACS Medicinal Chemistry Letters. 7:697-701
ROMK, the renal outer medullary potassium channel, is involved in potassium recycling at the thick ascending loop of Henle and potassium secretion at the cortical collecting duct in the kidney nephron. Because of this dual site of action, selective i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415e7bac5379921d8eb6098d8804f901
https://doi.org/10.1021/acsmedchemlett.6b00122
https://doi.org/10.1021/acsmedchemlett.6b00122
Autor:
Lee-Yuh Pai, Yuping Zhu, Richard Visconti, Xiaoyan Zhou, John P. Felix, Melba Hernandez, Jing Chen, Michael Margulis, Nardos Teumelsan, Sophie Roy, Kathleen A. Sullivan, Jessica Liu, Joseph M. Metzger, Aaron Corona, Gregory J. Kaczorowski, Maria L. Garcia, Lihu Yang, Shawn P. Walsh, Birgit T. Priest, Alexander Pasternak, Caryn Hampton, Emma R. Parmee, Vincent Tong, Brande Thomas-Fowlkes, Haifeng Tang, Magdalena Alonso-Galicia, Kashmira Shah, Michael J. Forrest, Richard M. Brochu, Ross Bentley, Sookhee Ha, Karen Owens, Aurash Shahripour, Andrew M. Swensen, Jessica Frie, Adam B. Weinglass, Timothy Bailey
Publikováno v:
ACS Medicinal Chemistry Letters. 6:747-752
A new subseries of ROMK inhibitors exemplified by 28 has been developed from the initial screening hit 1. The excellent selectivity for ROMK inhibition over related ion channels and pharmacokinetic properties across preclinical species support furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c1f32ec6c3f7a915fe446fd2867a1
https://doi.org/10.1021/ml500440u
https://doi.org/10.1021/ml500440u
Autor:
Yan Yan, Richard M. Brochu, Maria L. Garcia, Lihu Yang, Sophie Roy, Gregory J. Kaczorowski, Reynald K. de Jesus, Birgit T. Priest, Xiaoyan Zhou, Lee-Yuh Pai, Shawn P. Walsh, Yuping Zhu, Karen Owens, Caryn Hampton, Timothy Bailey, Andrew M. Swensen, Brande Thomas-Fowlkes, Magdalena Alonso-Galicia, John P. Felix, Melba Hernandez, Alexander Pasternak, Haifeng Tang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5829-5832
A sub-class of distinct small molecule ROMK inhibitors were developed from the original lead 1. Medicinal chemistry endeavors led to novel ROMK inhibitors with good ROMK functional potency and improved hERG selectivity. Two of the described ROMK inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5c348f365905a62caacd72f218a844
https://doi.org/10.1016/j.bmcl.2013.08.104
https://doi.org/10.1016/j.bmcl.2013.08.104
Autor:
Nina Jochnowitz, Catherine Abbadie, Clare London, Gregory J. Kaczorowski, Joseph L. Duffy, Birgit T. Priest, Erin McGowan, Kathryn A. Lyons, Maria L. Garcia, Vivien A. Warren, Xiaohua Li, Bindhu V. Karanam, Scott B. Hoyt, Brande Thomas-Fowlkes, John P. Felix, McHardy M. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3640-3645
A series of benzazepinones were synthesized and evaluated for block of Nav1.7 sodium channels. Compound 30 from this series displayed potent channel block, good selectivity versus other targets, and dose-dependent oral efficacy in a rat model of neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7dd437fffdf8a590df11a0f8a3fac9
https://doi.org/10.1016/j.bmcl.2013.03.121
https://doi.org/10.1016/j.bmcl.2013.03.121