Zobrazeno 1 - 10
of 539
pro vyhledávání: '"John P. Burke"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3118-3131 (2024)
The gene PIK3CA, encoding the catalytic subunit p110α of PI3Kα, is the second most frequently mutated gene in cancer, with the highest frequency oncogenic mutants occurring in the C-terminus of the kinase domain. The C-terminus has a dual function
Externí odkaz:
https://doaj.org/article/fb12b9be2c5242a0880c041b2806ad1a
Autor:
William P. Duggan, Batuhan Kisakol, Ina Woods, Mohammedreza Azimi, Heiko Dussmann, Joanna Fay, Tony O’Grady, Barry Maguire, Ian S. Reynolds, Manuela Salvucci, Daniel J. Slade, Deborah A. McNamara, John P. Burke, Jochen H.M. Prehn
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTMucinous colorectal cancer (CRC) is a common histological subtype of colorectal adenocarcinoma, associated with a poor response to chemoradiotherapy. The commensal facultative anaerobes fusobacteria, have been associated with poor prognosis s
Externí odkaz:
https://doaj.org/article/2b11e6dc763e4a1aacdfb8cd8e2a82f3
Autor:
John JA Burke
Publikováno v:
Academicus International Scientific Journal, Vol MMXXIV, Iss 30, Pp 98-111 (2024)
De-dollarization is a “significant reduction in the use of dollars in world trade and financial transactions, [as well as] decreasing national, institutional and corporate demand” for United States dollars. (Goldman Sachs 2023; Li Yuefen 2024) De
Externí odkaz:
https://doaj.org/article/5499a5132a334b5099a3fb91f13ec9d3
Autor:
Sarah A. Head, Carter Johnson, Saheli Sarkar, Andrew Matteson, Diana H. Marcantonio, Fei Hua, John M. Burke, Joshua F. Apgar, David Flowers
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 6, Pp 919-925 (2024)
Abstract Immune checkpoint inhibitors block the interaction between a receptor on one cell and its ligand on another cell, thus preventing the transduction of an immunosuppressive signal. While inhibition of the receptor–ligand interaction is key t
Externí odkaz:
https://doaj.org/article/c1102aa2ecc540dd91df07ff2a7b6864
Autor:
Deborah A McNamara, Jinru Shia, John P Burke, Manuela Salvucci, Daniel B Longley, Fiona Ginty, Andreas Lindner, Sanghee Cho, Elizabeth McDonough, John Graf, Canan Firat, Nil Urganci, Christine Surrette, Anna Matveeva, Batuhan Kisakol, Anthony O’Grady, Mohammadreza Azimi, Simon McDade, Jochen HM Prehn
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Objective Inducing tumour cell apoptosis is a primary objective of chemotherapy but, to date, there are no validated biomarkers of apoptosis sensitivity or resistance. Our objective was to image multiple apoptosis pathway proteins at single cell leve
Externí odkaz:
https://doaj.org/article/59942d4fee7b4e8199fc8767f377b824
Autor:
Timothy A Bates, Mila Trank-Greene, Xammy Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew AH Parson, Jessica R Ingram, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse
Publikováno v:
eLife, Vol 12 (2024)
Mycobacterium tuberculosis (Mtb) is known to survive within macrophages by compromising the integrity of the phagosomal compartment in which it resides. This activity primarily relies on the ESX-1 secretion system, predominantly involving the protein
Externí odkaz:
https://doaj.org/article/02546070fb4649659e3251bb6aab7254
Publikováno v:
eJHaem, Vol 4, Iss 4, Pp 912-920 (2023)
Abstract Pediatric non‐Hodgkin lymphoma includes over 30 histologies (many with subtypes), with approximately 800 cases per year in the US, compared to >60,000 cases of adult NHL annually. Improvements in survival in pediatric and adolescent mature
Externí odkaz:
https://doaj.org/article/7d5ff98091504603b95b733003cf5798
Autor:
Carolyn M. Boudreau, John S. Burke, Ashraf S. Yousif, Maya Sangesland, Sandra Jastrzebski, Chris Verschoor, George Kuchel, Daniel Lingwood, Harry Kleanthous, Iris De Bruijn, Victoria Landolfi, Saranya Sridhar, Galit Alter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Antibodies play a critical role in protection against influenza; yet titers and viral neutralization represent incomplete correlates of immunity. Instead, the ability of antibodies to leverage the antiviral power of the innate immune system
Externí odkaz:
https://doaj.org/article/60ac7790d439465f88919dbc719bf04c
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
Autor:
Yong Mi Choi, Dalila Ajjaji, Kaelin D. Fleming, Peter P. Borbat, Meredith L. Jenkins, Brandon E. Moeller, Shaveen Fernando, Surita R. Bhatia, Jack H. Freed, John E. Burke, Abdou Rachid Thiam, Michael V. Airola
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated proteins called perilipins (PLINs). During LD biogenesis, perilipin
Externí odkaz:
https://doaj.org/article/88d19ef3aa294ad58ab797d027080ed5
Autor:
Linlin Xu, Mazyar Shadman, Ian W. Flinn, Moshe Y. Levy, Ryan Porter, John M. Burke, Syed F. Zafar, Jennifer L. Cultrera, Jamal Misleh, Edwin C. Kingsley, Habte A. Yimer, Benjamin Freeman, Arvind Chaudhry, Praveen K. Tumula, Mitul D. Gandhi, Rocco Crescenzo, Kunthel By, Aileen Cohen, Dih-Yih Chen, Adam Idoine, Sudhir Manda, Jeff P. Sharman, Vanitha Ramakrishnan
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Not available.
Externí odkaz:
https://doaj.org/article/1c2ee5ac31c545ed8f557348df39cf33