Zobrazeno 1 - 9
of 9
pro vyhledávání: '"John P Zepecki"'
Autor:
John P Zepecki, David Karambizi, J Eduardo Fajardo, Kristin M Snyder, Charlotte Guetta-Terrier, Oliver Y Tang, Jia-Shu Chen, Atom Sarkar, Andras Fiser, Steven A Toms, Nikos Tapinos
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009086 (2021)
Within the glioblastoma cellular niche, glioma stem cells (GSCs) can give rise to differentiated glioma cells (DGCs) and, when necessary, DGCs can reciprocally give rise to GSCs to maintain the cellular equilibrium necessary for optimal tumor growth.
Externí odkaz:
https://doaj.org/article/0007be1e0d444154b35e4996ec091839
Autor:
Margot Martinez-Moreno, Timothy Mark O’Shea, John P. Zepecki, Alexander Olaru, Jennifer K. Ness, Robert Langer, Nikos Tapinos
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1950-1963 (2017)
Precise regulation of Egr2 transcription is fundamentally important to the control of peripheral myelination. Here, we describe a long non-coding RNA antisense to the promoter of Egr2 (Egr2-AS-RNA). During peripheral nerve injury, the expression of E
Externí odkaz:
https://doaj.org/article/677e14f952c54f5aa8432b8b790c7841
Autor:
Charlotte Guetta-Terrier, David Karambizi, Bedia Akosman, John P. Zepecki, Jia-Shu Chen, Suchitra Kamle, J. Eduardo Fajardo, Andras Fiser, Ritambhara Singh, Steven A. Toms, Chun Geun Lee, Jack A. Elias, Nikos Tapinos
Publikováno v:
Cancer Research.
Chi3l1 (chitinase 3-like 1) is a secreted protein that is highly expressed in glioblastoma. Here, we show that Chi3l1 alters the state of glioma stem cells (GSCs) to support tumor growth. Exposure of patient-derived GSCs to Chi3l1 reduced the frequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::618b7700eb3d01f7b7259322367a45f6
https://doi.org/10.1158/0008-5472.can-21-3629
https://doi.org/10.1158/0008-5472.can-21-3629
Autor:
Steven A. Toms, Nikos Tapinos, Atom Sarkar, Kristin M. Snyder, Andras Fiser, J. Eduardo Fajardo, Oliver Y. Tang, Jia-Shu Chen, David Karambizi, John P. Zepecki, Charlotte Guetta-Terrier
Within the glioblastoma cellular niche, glioma stem cells (GSCs) can give rise to differentiated glioma cells (DGCs) and, when necessary, DGCs can reciprocally give rise to GSCs to maintain the cellular equilibrium necessary for optimal tumor growth.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c0bdf6ad726c3a8c45c60ae27315de6
https://doi.org/10.1101/2020.08.28.271536
https://doi.org/10.1101/2020.08.28.271536
Autor:
Eduardo Fajardo, John P. Zepecki, Nikos Tapinos, Andras Fiser, M. M. Moreno, J. Ness, Kristin M. Snyder, Steven A. Toms, Atom Sarkar
Publikováno v:
Oncogene
Migration of human glioma cells (hGCs) within the brain parenchyma makes glioblastoma one of the most aggressive and lethal tumors. Studies of the cellular and molecular mechanisms underlying hGC migration are hindered by the limitations of existing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b65e3155be030a685d768f44ed599d
https://doi.org/10.1038/s41388-018-0546-z
https://doi.org/10.1038/s41388-018-0546-z
Autor:
Alexander Olaru, Margot Martinez-Moreno, John P. Zepecki, Nikos Tapinos, Timothy M. O’Shea, Jennifer K. Ness, Robert Langer
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1950-1963 (2017)
Summary Precise regulation of Egr2 transcription is fundamentally important to the control of peripheral myelination. Here, we describe a long non-coding RNA antisense to the promoter of Egr2 (Egr2-AS-RNA). During peripheral nerve injury, the express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cbf2e22066b8b73d9e9433e327fc80
http://www.sciencedirect.com/science/article/pii/S2211124717310616
http://www.sciencedirect.com/science/article/pii/S2211124717310616
Publikováno v:
European Journal of Cancer. 138:S42-S43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc2f234dacfa3943c01dd077af0c9d99
https://doi.org/10.1016/s0959-8049(20)31188-6
https://doi.org/10.1016/s0959-8049(20)31188-6
Publikováno v:
Journal of Visualized Experiments.
Glioblastoma is one of the most aggressive human cancers due to extensive cellular heterogeneity and the migration properties of hGCs. In order to better understand the molecular mechanisms underlying glioma cell migration, an ability to study the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814dcd4880506247dcf20176480146a3
https://doi.org/10.3791/59744
https://doi.org/10.3791/59744
Autor:
Richard J. Gilbert, Nikos Tapinos, Derek Merck, Owen P. Leary, John P. Zepecki, Steven A. Toms
Publikováno v:
Neuro Oncol
BACKGROUND Invasion of glioblastoma tumor cells beyond the visible margins is hypothesized to mediate tumor spread and recurrence, and thereby affect poor survival. Radiomic biomarkers associated with the extent of tumor infiltration are virtually no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b78a22357681646ee2315b475453c8f
https://europepmc.org/articles/PMC6847375/
https://europepmc.org/articles/PMC6847375/