Zobrazeno 1 - 10
of 86
pro vyhledávání: '"John P Thomson"'
Autor:
Marcus J. Lyall, Jessy Cartier, James A Richards, Diego Cobice, John P Thomson, Richard R Meehan, Stephen M Anderton, Amanda J Drake
Publikováno v:
Wellcome Open Research, Vol 2 (2017)
Background: Non-alcoholic fatty liver disease (NAFLD) is a global health issue. Dietary methyl donor restriction is used to induce a NAFLD/non-alcoholic steatohepatitis (NASH) phenotype in rodents, however the extent to which this model reflects huma
Externí odkaz:
https://doaj.org/article/3e35299004dd4e0a8deca912246023ec
Autor:
Rhoanne C McPherson, Joanne E Konkel, Catriona T Prendergast, John P Thomson, Raffaele Ottaviano, Melanie D Leech, Oliver Kay, Stephanie E J Zandee, Claire H Sweenie, David C Wraith, Richard R Meehan, Amanda J Drake, Stephen M Anderton
Publikováno v:
eLife, Vol 3 (2014)
Clinically effective antigen-based immunotherapy must silence antigen-experienced effector T cells (Teff) driving ongoing immune pathology. Using CD4+ autoimmune Teff cells, we demonstrate that peptide immunotherapy (PIT) is strictly dependent upon s
Externí odkaz:
https://doaj.org/article/75862575f3834eacaa2391d9b4e2cb34
Autor:
Christopher Smith, Gillian Leggett, Anthoor Jayaprakash, Mohammed Khan, John M. Thomson, Balasubramaniam Vijayan, Andrew Fraser, John S. Leeds
Publikováno v:
DEN Open, Vol 4, Iss 1, Pp n/a-n/a (2024)
Abstract Objectives Lower gastrointestinal bleeding is a common presentation with little data concerning risk factors for adverse outcomes. The aim was to derive and validate a scoring system to stratify risk in lower gastrointestinal bleeding and co
Externí odkaz:
https://doaj.org/article/9dba2a25f4dc491dbb1931590b5dcfa4
Autor:
Robert L. Hollis, John P. Thomson, Juliette van Baal, Narthana Ilenkovan, Michael Churchman, Koen van de Vijver, Frederike Dijk, Alison M. Meynert, Clare Bartos, Tzyvia Rye, Ian Croy, Patricia Diana, Mignon van Gent, Helen Creedon, Rachel Nirsimloo, Christianne Lok, Charlie Gourley, C. Simon Herrington
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Low grade serous ovarian carcinoma (LGSOC) demonstrates unique clinical and molecular features compared to other ovarian cancer types. The relationship between common histological features of LGSOC and molecular events, such as hormone recep
Externí odkaz:
https://doaj.org/article/8acb6378ec15437ba487763df432313d
Autor:
Nicholas T. Ventham, Nicholas A. Kennedy, Rahul Kalla, Alex T. Adams, Alexandra Noble, Holly Ennis, Craig Mowat, Malcolm G. Dunlop, Jack Satsangi, Ian Arnott, Aiden Cahill, Malcolm Smith, Tariq Ahmad, Sreedhar Subramanian, Simon Travis, John Morris, John Hamlin, Anjan Dhar, Chuka Nwokolo, Cathryn Edwards, Tom Creed, Stuart Bloom, Mohamed Yousif, Linzi Thomas, Simon Campbell, Stephen J. Lewis, Shaji Sebastian, Sandip Sen, Simon Lal, Chris Hawkey, Charles Murray, Fraser Cummings, Jason Goh, James O. Lindsay, Naila Arebi, Lindsay Potts, Aileen J. McKinley, John M. Thomson, John A. Todd, Mhairi Collie, Ashley Mowat, Daniel R. Gaya, Jack Winter, Graham D. Naismith, Catriona Keerie, Steff Lewis, Robin J. Prescott, Gordan Lauc, Harry Campbell, Dermot P.B. McGovern, Vito Annese, Vlatka Zoldoš, Iain K. Permberton, Manfred Wuhrer, Daniel Kolarich, Daryl L. Fernandes, Evropi Theorodorou, Victoria Merrick Daniel I. Spencer, Richard A. Gardner, Ray Doran, Archana Shubhakar, Ray Boyapati, Igor Rudan, Paolo Lionetti, Irena Trbojević Akmačić, Jasminka Krištić, Frano Vuč ković, Jerko Štambuk, Mislav Novokmet, Maja Pučić-Baković, Olga Gornik, Angelo Andriulli, Laura Cantoro, Giancarlo Sturniolo, Gionata Fiorino, Natalia Manetti, Anna Latiano, Anna Kohn, Renata D’Inca`, Silvio Danese, Ian D. Arnott, Colin L. Noble, Charlie W. Lees, Alan G. Shand, Gwo-Tzer Ho, Lee Murphy, Jude Gibson, Louise Evenden, Nicola Wrobel, Tamara Gilchrist, Angie Fawkes, Guinevere S.M. Kammeijer, Florent Clerc, Noortje de Haan, Aleksandar Vojta, Ivana Samaržija, Dora Markulin, Marija Klasić, Paula Dobrinić, Yurii Aulchenko, Tim van den Heuve, Daisy Jonkers, Marieke Pierik
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 431-450 (2023)
Background & Aims: DNA methylation alterations may provide important insights into gene-environment interaction in cancer, aging, and complex diseases, such as inflammatory bowel disease (IBD). We aim first to determine whether the circulating DNA me
Externí odkaz:
https://doaj.org/article/f32b67ecfa854c6487a3c5196a5070e3
Autor:
Marcus J. Lyall, John P. Thomson, Jessy Cartier, Raffaele Ottaviano, Timothy J. Kendall, Richard R. Meehan, Amanda J. Drake
Publikováno v:
Epigenetics, Vol 15, Iss 1-2, Pp 61-71 (2020)
Non-alcoholic fatty liver disease (NAFLD) is now the commonest cause of liver disease in developed countries affecting 25–33% of the general population and up to 75% of those with obesity. Recent data suggest that alterations in DNA methylation may
Externí odkaz:
https://doaj.org/article/0306e657ff6a4edc950dc78da79355a9
Autor:
Zhaoliang Meng, Yuan Yang, Yong Gao, Shengsheng Ai, Yue Zhang, Yaru Lv, Zetao Zhang, Yang Wen, Lei Wu, Ping Zhang, John Douglas Thomson
Publikováno v:
IEEE Access, Vol 8, Pp 94731-94747 (2020)
An insulated gate bipolar transistor (IGBT) driver is crucial for improving the reliability of a power electronics system. This paper proposes a method for predicting the optimal driving strategy of high-power IGBT module based on backpropagation neu
Externí odkaz:
https://doaj.org/article/2ec12be9d01c45739debf71cc546e4f4
Autor:
Matthew C. Sinton, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Sara Wernig-Zorc, John P. Thomson, Roderick N. Carter, Marcus J. Lyall, Paul D. Walker, Alpesh Thakker, Richard R. Meehan, Gareth G. Lavery, Nicholas M. Morton, Christian Ludwig, Daniel A. Tennant, David C. Hay, Amanda J. Drake
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101931- (2021)
Summary: Nonalcoholic fatty liver disease (NAFLD) is currently the most prevalent form of liver disease worldwide. This term encompasses a spectrum of pathologies, from benign hepatic steatosis to non-alcoholic steatohepatitis, which have, to date, b
Externí odkaz:
https://doaj.org/article/231ee5e1aa334f8c91d6ea963c63a1fc
Autor:
Karin Purshouse, John P Thomson, Mahéva Vallet, Lorna Alexander, Isaac Bonisteel, Maree Brennan, David A Cameron, Jonine D Figueroa, Elizabeth Furrie, Pamela Haig, Mattea Heck, Hugh McCaughan, Paul Mitchell, Heather McVicars, Lorraine Primrose, Ines Silva, Kate Templeton, Natalie Wilson, Peter S Hall
Publikováno v:
Purshouse, K, Thomson, J P, Vallet, M, Alexander, L, Bonisteel, I, Brennan, M, Cameron, D A, Figueroa, J D, Furrie, E, Haig, P, Heck, M, Mccaughan, H, Mitchell, P, Mcvicars, H, Primrose, L, Silva, I, Templeton, K, Wilson, N & Hall, P S 2023, ' The Scottish COVID Cancer Immunity Prevalence Study: A Longitudinal Study of SARS-CoV-2 Immune Response in Patients Receiving Anti–Cancer Treatment ', The Oncologist . https://doi.org/10.1093/oncolo/oyac257, https://doi.org/10.1093/oncolo/oyac257
Background Cancer and anti-cancer treatment (ACT) may be risk factors for severe SARS-CoV-2 infection and limited vaccine efficacy. Long–term longitudinal studies are needed to evaluate these risks. The Scottish COVID cancer immunity prevalence (SC
Autor:
Sophie J. Warlow, Martyna Adamowicz, John P. Thomson, Robert A. Wescott, Christelle Robert, Lara M. Carey, Helen Thain, Kate Cuschieri, Lucy Q. Li, Brendan Conn, Ashley Hay, Iain J. Nixon, Timothy J. Aitman
Publikováno v:
Warlow, S J, Adamowicz, M, Thomson, J P, Wescott, R A, Robert, C, Carey, L M, Thain, H, Cuschieri, K, Li, L Q, Conn, B, Hay, A, Nixon, I J & Aitman, T J 2022, ' Longitudinal measurement of HPV copy number in cell-free DNA is associated with patient outcomes in HPV-positive oropharyngeal cancer ', EJSO-European Journal of Surgical Oncology, vol. 48, no. 6, pp. 1224-1234 . https://doi.org/10.1016/j.ejso.2022.03.232
INTRODUCTION: Oropharyngeal squamous cell carcinoma (OPSCC) is increasing in global prevalence and is divided into two types dependent on association with human papillomavirus (HPV). Assay of HPV copy number in plasma cell-free DNA (cfDNA) provides a