Zobrazeno 1 - 10
of 64
pro vyhledávání: '"John P Rooney"'
Autor:
John P Rooney, Brian Chorley, Steven Hiemstra, Steven Wink, Xuting Wang, Douglas A Bell, Bob van de Water, J Christopher Corton
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239367 (2020)
Nuclear factor erythroid-2 related factor 2 (NRF2) encoded by the NFE2L2 gene is a transcription factor critical for protecting cells from chemically-induced oxidative stress. We developed computational procedures to identify chemical modulators of N
Externí odkaz:
https://doaj.org/article/4f6e9e8850314c27a65cda7e60d89875
Autor:
Ramiya Kumar, Linda C Mota, Elizabeth J Litoff, John P Rooney, W Tyler Boswell, Elliott Courter, Charles M Henderson, Juan P Hernandez, J Christopher Corton, David D Moore, William S Baldwin
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174355 (2017)
Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption, metabolism, distribution, or elimination (ADME) of chemicals from individuals. Key models include those for xenosensing transcription factors and cy
Externí odkaz:
https://doaj.org/article/c116c926bd81428a80c52e51f7ed9696
Autor:
Anthony L Luz, John P Rooney, Laura L Kubik, Claudia P Gonzalez, Dong Hoon Song, Joel N Meyer
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168738 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0130940.].
Externí odkaz:
https://doaj.org/article/cf89159ec82345ac909a4adf187ac507
Autor:
Anthony L Luz, John P Rooney, Laura L Kubik, Claudia P Gonzalez, Dong Hoon Song, Joel N Meyer
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130940 (2015)
Mitochondrial dysfunction has been linked to myriad human diseases and toxicant exposures, highlighting the need for assays capable of rapidly assessing mitochondrial health in vivo. Here, using the Seahorse XFe24 Analyzer and the pharmacological inh
Externí odkaz:
https://doaj.org/article/8242486b4b634ace947218568e578f4f
Supplementary Tables S1-S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c152671c61ecb05654e7f0caaf82d61
https://doi.org/10.1158/1541-7786.22518474
https://doi.org/10.1158/1541-7786.22518474
Protein synthesis and degradation are posttranscriptional pathways used by cells to regulate protein levels. We have developed a systems biology approach to identify targets of posttranscriptional regulation and we have employed this system in Saccha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4696c3e95f92287c62a4270469b6b2cb
https://doi.org/10.1158/1541-7786.c.6541932.v1
https://doi.org/10.1158/1541-7786.c.6541932.v1
Autor:
Scott S. Auerbach, Nicole Kleinstreuer, Eugene N. Muratov, John P. Rooney, Charles Schmitt, Ivan Rusyn, Alexander Tropsha, Vinicius M. Alves
Publikováno v:
Alternatives to Laboratory Animals. 49:73-82
New Approach Methodologies (NAMs) that employ artificial intelligence (AI) for predicting adverse effects of chemicals have generated optimistic expectations as alternatives to animal testing. However, the major underappreciated challenge in developi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8312682993504a83e6a5794977bb58d4
https://doi.org/10.1177/02611929211029635
https://doi.org/10.1177/02611929211029635
Autor:
J. Christopher Corton, Shiuan Chen, Gregory Chang, Natalia Ryan, Rinie van Beuningen, John P. Rooney, Jui-Hua Hsieh, René Houtman, Jie Liu
Publikováno v:
Chemical Research in Toxicology. 34:313-329
Identification of chemicals that affect hormone-regulated systems will help to predict endocrine disruption. In our previous study, a 46 gene biomarker was found to be an accurate predictor of estrogen receptor (ER) α modulation in chemically treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7335da66dc54adf425d28066e4be2c32
https://doi.org/10.1021/acs.chemrestox.0c00243
https://doi.org/10.1021/acs.chemrestox.0c00243
Thresholds Derived From Common Measures in Rat Studies Are Predictive of Liver Tumorigenic Chemicals
Autor:
J. Christopher Corton, Hisham A. El-Masri, Katharine L Korunes, John P. Rooney, Shihan He, Cari Martini, Jason M. Brown, Ying Liu, Katie Paul-Friedman, Jaleh Abedini
Publikováno v:
Toxicol Pathol
We hypothesized that typical tissue and clinical chemistry (ClinChem) end points measured in rat toxicity studies exhibit chemical-independent biological thresholds beyond which cancer occurs. Using the rat in vivo TG-GATES study, 75 chemicals were e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109534ce11b1c5e443c4b8b86111b301
https://doi.org/10.1177/0192623320960412
https://doi.org/10.1177/0192623320960412
Autor:
Charles E. Wood, J. Christopher Corton, Thomas A. Hill, Jaleh Abedini, Hisham A. El-Masri, John P. Rooney
Publikováno v:
Toxicol Sci
Traditional methods for cancer risk assessment are resource-intensive, retrospective, and not feasible for the vast majority of environmental chemicals. In this study, we investigated whether quantitative genomic data from short-term studies may be u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1660890f26d35b0766ea70dabf383c
https://doi.org/10.1093/toxsci/kfaa102
https://doi.org/10.1093/toxsci/kfaa102