Zobrazeno 1 - 10
of 147
pro vyhledávání: '"John P Rooney"'
Publikováno v:
Frontiers in Marine Science, Vol 8 (2022)
Mesophotic reefs (30–150 m) occur in the tropics and subtropics at depths beyond most scientific diving, thereby making conventional surveys challenging. Towed cameras, submersibles, and mixed-gas divers were used to survey the mesophotic reef fish
Externí odkaz:
https://doaj.org/article/06a2b48596ee481bb53a61a50c040a8b
Autor:
Kathleen A. Hershberger, John P. Rooney, Elena A. Turner, Lauren J. Donoghue, Rakesh Bodhicharla, Laura L. Maurer, Ian T. Ryde, Jina J. Kim, Rashmi Joglekar, Jonathan D. Hibshman, Latasha L. Smith, Dhaval P. Bhatt, Olga R. Ilkayeva, Matthew D. Hirschey, Joel N. Meyer
Publikováno v:
Redox Biology, Vol 43, Iss , Pp 102000- (2021)
The consequences of damage to the mitochondrial genome (mtDNA) are poorly understood, although mtDNA is more susceptible to damage resulting from some genotoxicants than nuclear DNA (nucDNA), and many environmental toxicants target the mitochondria.
Externí odkaz:
https://doaj.org/article/b4cfc3d8ec28428e988509c328dc431a
Autor:
John P Rooney, Brian Chorley, Steven Hiemstra, Steven Wink, Xuting Wang, Douglas A Bell, Bob van de Water, J Christopher Corton
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239367 (2020)
Nuclear factor erythroid-2 related factor 2 (NRF2) encoded by the NFE2L2 gene is a transcription factor critical for protecting cells from chemically-induced oxidative stress. We developed computational procedures to identify chemical modulators of N
Externí odkaz:
https://doaj.org/article/4f6e9e8850314c27a65cda7e60d89875
Supplementary Tables S1-S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c152671c61ecb05654e7f0caaf82d61
https://doi.org/10.1158/1541-7786.22518474
https://doi.org/10.1158/1541-7786.22518474
Protein synthesis and degradation are posttranscriptional pathways used by cells to regulate protein levels. We have developed a systems biology approach to identify targets of posttranscriptional regulation and we have employed this system in Saccha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4696c3e95f92287c62a4270469b6b2cb
https://doi.org/10.1158/1541-7786.c.6541932.v1
https://doi.org/10.1158/1541-7786.c.6541932.v1
Autor:
Ramiya Kumar, Linda C Mota, Elizabeth J Litoff, John P Rooney, W Tyler Boswell, Elliott Courter, Charles M Henderson, Juan P Hernandez, J Christopher Corton, David D Moore, William S Baldwin
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174355 (2017)
Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption, metabolism, distribution, or elimination (ADME) of chemicals from individuals. Key models include those for xenosensing transcription factors and cy
Externí odkaz:
https://doaj.org/article/c116c926bd81428a80c52e51f7ed9696
Autor:
Scott S. Auerbach, Nicole Kleinstreuer, Eugene N. Muratov, John P. Rooney, Charles Schmitt, Ivan Rusyn, Alexander Tropsha, Vinicius M. Alves
Publikováno v:
Alternatives to Laboratory Animals. 49:73-82
New Approach Methodologies (NAMs) that employ artificial intelligence (AI) for predicting adverse effects of chemicals have generated optimistic expectations as alternatives to animal testing. However, the major underappreciated challenge in developi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8312682993504a83e6a5794977bb58d4
https://doi.org/10.1177/02611929211029635
https://doi.org/10.1177/02611929211029635
Autor:
J. Christopher Corton, Shiuan Chen, Gregory Chang, Natalia Ryan, Rinie van Beuningen, John P. Rooney, Jui-Hua Hsieh, René Houtman, Jie Liu
Publikováno v:
Chemical Research in Toxicology. 34:313-329
Identification of chemicals that affect hormone-regulated systems will help to predict endocrine disruption. In our previous study, a 46 gene biomarker was found to be an accurate predictor of estrogen receptor (ER) α modulation in chemically treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7335da66dc54adf425d28066e4be2c32
https://doi.org/10.1021/acs.chemrestox.0c00243
https://doi.org/10.1021/acs.chemrestox.0c00243
Autor:
Anthony L Luz, John P Rooney, Laura L Kubik, Claudia P Gonzalez, Dong Hoon Song, Joel N Meyer
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168738 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0130940.].
Externí odkaz:
https://doaj.org/article/cf89159ec82345ac909a4adf187ac507
Autor:
Andrew E Gray, Ivor D Williams, Kostantinos A Stamoulis, Raymond C Boland, Kevin C Lino, Brian B Hauk, Jason C Leonard, John J Rooney, Jacob M Asher, Keolohilani H Lopes, Randall K Kosaki
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167724 (2016)
Visual survey by divers using open-circuit (OC) SCUBA is the most widely used approach to survey coral reef fishes. Therefore, it is important to quantify sources of bias in OC surveys, such as the possibility that avoidance of OC divers by fishes ca
Externí odkaz:
https://doaj.org/article/0ad74b117377456da2021751596b7ae3