Zobrazeno 1 - 10
of 22
pro vyhledávání: '"John P Parisot"'
Autor:
Tony S Cardno, Yosuke Shimaki, Brad E Sleebs, Kurt Lackovic, John P Parisot, Rebecca M Moss, Caillan Crowe-McAuliffe, Suneeth F Mathew, Christina D Edgar, Torsten Kleffmann, Warren P Tate
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139036 (2015)
Frameshifting during translation of viral or in rare cases cellular mRNA results in the synthesis of proteins from two overlapping reading frames within the same mRNA. In HIV-1 the protease, reverse transcriptase, and integrase enzymes are in a secon
Externí odkaz:
https://doaj.org/article/20a5de53f7ec45b591411810ac7d69b1
Autor:
John J McNeil, Paula Lorgelly, Stephen F. Fox, Michael Wright, John P Parisot, Gary Richardson, Lara Lipton, Mark Lucas, David M. Ashley, David Thomas
Publikováno v:
Drug Discovery Today. 20:1429-1432
Genomic cancer medicine promises revolutionary change in oncology. The impacts of 'personalized medicine', based upon a molecular classification of cancer and linked to targeted therapies, will extend from individual patient outcomes to the health ec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f3ec4af242eb1b25ed857f07d2b2e9
https://doi.org/10.1016/j.drudis.2015.10.009
https://doi.org/10.1016/j.drudis.2015.10.009
Autor:
Ian P. Street, Erinna F. Lee, Brad E. Sleebs, Andrew H. Wei, Rebecca M Moss, Peter M. Colman, Effie Hatzis, Guillaume Lessene, John P Parisot, Jerry M. Adams, David C.S. Huang, Mark F. van Delft, Keith G. Watson, Wilhelmus J A Kersten, Sanjitha Kulasegaram, Hong Yang, Peter E. Czabotar, Jonathan B. Baell, George Nikolakopoulos, Kym N Lowes, Lin Chen, W. Douglas Fairlie
Publikováno v:
Journal of Medicinal Chemistry. 56:5514-5540
Developing potent molecules that inhibit Bcl-2 family mediated apoptosis affords opportunities to treat cancers via reactivation of the cell death machinery. We describe the hit-to-lead development of selective Bcl-XL inhibitors originating from a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677936ab828328fb7f66e0e2d4cd230e
https://doi.org/10.1021/jm400556w
https://doi.org/10.1021/jm400556w
Autor:
Ken Doig, Thomas John, Alexander Dobrovic, Stephen B. Fox, John J McNeil, Theresa M. Hayes, David Thomas, Heather Thorne, Paul J. McMurrick, John P Parisot, Paula Lorgelly, Lara Lipton, Mark Lucas, David M. Ashley, Andrew Fellowes, Paul A. James, Brett Doble, Gary Richardson
Publikováno v:
Journal of Personalized Medicine
Volume 5
Issue 4
Pages 354-369
BASE-Bielefeld Academic Search Engine
Journal of Personalized Medicine, Vol 5, Iss 4, Pp 354-369 (2015)
Volume 5
Issue 4
Pages 354-369
BASE-Bielefeld Academic Search Engine
Journal of Personalized Medicine, Vol 5, Iss 4, Pp 354-369 (2015)
“Cancer 2015” is a longitudinal and prospective cohort. It is a phased study whose aim was to pilot recruiting 1000 patients during phase 1 to establish the feasibility of providing a population-based genomics cohort. Newly diagnosed adult patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e1f4e59331c33389ba219b12887933
Autor:
Warren P. Tate, John P Parisot, Rebecca M Moss, Suneeth F. Mathew, Torsten Kleffmann, Tony S. Cardno, Brad E. Sleebs, Yosuke Shimaki, Caillan Crowe-McAuliffe, Kurt Lackovic, Christina D. Edgar
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 10, p e0139036 (2015)
PLoS ONE, Vol 10, Iss 10, p e0139036 (2015)
Frameshifting during translation of viral or in rare cases cellular mRNA results in the synthesis of proteins from two overlapping reading frames within the same mRNA. In HIV-1 the protease, reverse transcriptase, and integrase enzymes are in a secon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1307c68b2ad27c614da560754eed9eb
https://pubmed.ncbi.nlm.nih.gov/26447468
https://pubmed.ncbi.nlm.nih.gov/26447468
Autor:
Alexander Dobrovic, Ravikiran Vedururu, Grant A. McArthur, Jia-Min B Pang, Jason Ellul, Andrew Fellowes, David Thomas, Stephen Q. Wong, Angela Y-C Tan, Stephen B. Fox, John P Parisot, Anthony Bell, Hongdo Do, Ken Doig, Jason Li
Publikováno v:
BMC Medical Genomics
Background Clinical specimens undergoing diagnostic molecular pathology testing are fixed in formalin due to the necessity for detailed morphological assessment. However, formalin fixation can cause major issues with molecular testing, as it causes D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a376e580c8ddbe63822d46b62c240a
https://doi.org/10.1186/1755-8794-7-23
https://doi.org/10.1186/1755-8794-7-23
Autor:
David C.S. Huang, Nathan Toovey, Ian P. Street, Amelia Vom, M.J. Roy, Brian J. Smith, Jonathan B. Baell, Hong Yang, Effie Hatzis, Rebecca M Moss, Guillaume Lessene, Peter E. Czabotar, Peter M. Colman, John P Parisot, Ryan Brady
Publikováno v:
Journal of medicinal chemistry. 57(4)
The prosurvival BCL-2 proteins are attractive yet challenging targets for medicinal chemists. Their involvement in the initiation and progression of many, if not all, tumors makes them prime targets for developing new anticancer therapies. We present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9386f449878ccfa73efa4dc6c05983f9
https://pubmed.ncbi.nlm.nih.gov/24456288
https://pubmed.ncbi.nlm.nih.gov/24456288
Autor:
Xiu F. Hu, John P. Parisot, John Zalcberg, A. E. Wakeling, Robert L. Sutherland, Mario Deluise
Publikováno v:
International Journal of Cancer. 62:480-484
Both estrogen receptor-positive (ER + ), tamoxifen-sensitive (5-21) and tamoxifen-resistant (5-23) subclones of the parental MCF-7 breast cancer cell line were used in competitive ligand binding studies involving either [ 3 H]lcl 182,780 or 4-OH-[ 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d563624f215130329d401bf16cd6b080
https://doi.org/10.1002/ijc.2910620420
https://doi.org/10.1002/ijc.2910620420
Autor:
Ian P. Street, Patrick O. Humbert, Samuel A. Manning, Helena E. Richardson, Tanja Schlosser, Lee F. Willoughby, John P Parisot, Anthony M. Brumby
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 6, Iss 2, Pp 521-529 (2013)
Disease Models & Mechanisms, Vol 6, Iss 2, Pp 521-529 (2013)
Summary Anti-cancer drug development involves enormous expenditure and risk. Key to the rapid and economic identification of novel, bioavailable anti-tumor chemicals is the use of appropriate in vivo tumor models suitable for large-scale screening. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2c21665aad384f55f7e6765891f318
https://pubmed.ncbi.nlm.nih.gov/22996645
https://pubmed.ncbi.nlm.nih.gov/22996645
Autor:
John D. Bentley, Ian P. Street, Karen J Loft, John P Parisot, Jonathan B. Baell, Hong Yang, Hendrik Falk, Brendon J. Monahan, Meghan Hattarki, Regina Surjadi, Thomas S. Peat, Olan Dolezal, Joanne L Alcindor, Tim Thomas, George Nikolakopoulos, Theresa Connor, James M. Murphy
Publikováno v:
Journal of biomolecular screening. 16(10)
Epigenetic aberrations are increasingly regarded as key factors in cancer progression. Recently, deregulation of histone acetyltransferases (HATs) has been linked to several types of cancer. Monocytic leukemia zinc finger protein (MOZ) is a member of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c45791853f66b64a40876067c803e29
https://pubmed.ncbi.nlm.nih.gov/22086725
https://pubmed.ncbi.nlm.nih.gov/22086725