Zobrazeno 1 - 10
of 221
pro vyhledávání: '"John P Higgins"'
Publikováno v:
IJU Case Reports, Vol 5, Iss 5, Pp 346-349 (2022)
Introduction Isolated seminal vesicle cysts not associated with Zinner syndrome is a rare disorder that can present initially with urinary obstructive symptoms or nonspecific groin pain. Case description We present the uncommon case of a dermoid cyst
Externí odkaz:
https://doaj.org/article/1eebe041d44c4e679d59a04efe7dfc35
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005734 (2015)
Human kidney function declines with age, accompanied by stereotyped changes in gene expression and histopathology, but the mechanisms underlying these changes are largely unknown. To identify potential regulators of kidney aging, we compared age-asso
Externí odkaz:
https://doaj.org/article/d10e927a70444cf09165dbd5fb4222f3
Autor:
Yohannes T Ghebremariam, Keisuke Yamada, Jerry C Lee, Christine L C Johnson, Dorothee Atzler, Maike Anderssohn, Rani Agrawal, John P Higgins, Andrew J Patterson, Rainer H Böger, John P Cooke
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60653 (2013)
Genetic and pharmacological studies have shown that impairment of the nitric oxide (NO) synthase (NOS) pathway is associated with hypertension and insulin-resistance (IR). In addition, inhibition of NOS by the endogenous inhibitor, asymmetric dimethy
Externí odkaz:
https://doaj.org/article/920ed60c235b4013b2cfdf504836a39c
Autor:
Justin Cuff, Keyan Salari, Nicole Clarke, Ghada E Esheba, Andrew D Forster, Stephanie Huang, Robert B West, John P Higgins, Teri A Longacre, Jonathan R Pollack
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74562 (2013)
Clear cell carcinoma (CCC) is a histologically distinct carcinoma subtype that arises in several organ systems and is marked by cytoplasmic clearing, attributed to abundant intracellular glycogen. Previously, transcription factor hepatocyte nuclear f
Externí odkaz:
https://doaj.org/article/2e96471e6b864911be303228fc7152d3
Autor:
Sameer Malhotra, Jacques Lapointe, Keyan Salari, John P Higgins, Michelle Ferrari, Kelli Montgomery, Matt van de Rijn, James D Brooks, Jonathan R Pollack
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20293 (2011)
Prostate cancer exhibits tremendous variability in clinical behavior, ranging from indolent to lethal disease. Better prognostic markers are needed to stratify patients for appropriately aggressive therapy. By expression profiling, we can identify a
Externí odkaz:
https://doaj.org/article/673a73c048b14e30a7e2a0d43e6b67de
Autor:
Daniel C. De Souza, Nicolas Hebert, Erica B. Esrick, M. Felicia Ciuculescu, Natasha M. Archer, Myriam Armant, Étienne Audureau, Christian Brendel, Giuseppe Di Caprio, Frédéric Galactéros, Donghui Liu, Amanda McCabe, Emily Morris, Ethan Schonbrun, Dillon Williams, David K. Wood, David A. Williams, Pablo Bartolucci, John M. Higgins
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract We previously reported initial clinical results of post-transcriptional gene silencing of BCL11A expression (NCT 03282656) reversing the fetal to adult hemoglobin switch. A goal of this approach is to increase fetal hemoglobin (HbF) expressi
Externí odkaz:
https://doaj.org/article/c27e3b0ea4ac4641bfd4b6b6b60347e0
Autor:
John A. Higgins, Danielle Santiago Ramos, Stefania Gili, Cornelia Spetea, Scott Kanoski, Darren Ha, Alicia A. McDonough, Jang H. Youn
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
As the most abundant cation in archaeal, bacterial, and eukaryotic cells, potassium (K+) is an essential element for life. While much is known about the machinery of transcellular and paracellular K transport–channels, pumps, co-transporters, and t
Externí odkaz:
https://doaj.org/article/6b378dbf9368413786495828c89e6c06
Autor:
Kimberley K. Mayfield, Anton Eisenhauer, Danielle P. Santiago Ramos, John A. Higgins, Tristan J. Horner, Maureen Auro, Tomas Magna, Nils Moosdorf, Matthew A. Charette, Meagan Eagle Gonneea, Carolyn E. Brady, Nemanja Komar, Bernhard Peucker-Ehrenbrink, Adina Paytan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Groundwater discharge is a mechanism that transports chemicals from inland systems to the ocean, but it has been considered of secondary influence compared to rivers. Here the authors assess the global significance of groundwater discharge, finding t
Externí odkaz:
https://doaj.org/article/18dda10878ea4e5f8d911ae2975143cd
Autor:
Harsh Singh, B.A., Inis Isak, B.S., William M. Cregar, M.D., John D. Higgins, M.D., Amar S. Vadhera, B.S., Allison K. Perry, B.S., Gregory P. Nicholson, M.D., Brian J. Cole, M.D., M.B.A., Nikhil N. Verma, M.D.
Publikováno v:
Arthroscopy, Sports Medicine, and Rehabilitation, Vol 3, Iss 6, Pp e1853-e1856 (2021)
Purpose: To establish an infection rate following primary arthroscopic rotator cuff repair (ARCR) from a single institutional database and to ascertain whether there is a relationship between the use of preoperative corticosteroid injection (CSI) and
Externí odkaz:
https://doaj.org/article/77d49ad4d012493bbbc04cc6bc3eff8f
Autor:
Athena C. Geisness, Melissa Azul, Dillon Williams, Hannah Szafraniec, Daniel C. De Souza, John M. Higgins, David K. Wood
Publikováno v:
Haematologica, Vol 107, Iss 6 (2021)
Sickle cell disease (SCD) is characterized by sickle hemoglobin (HbS) which polymerizes under deoxygenated conditions to form a stiff, sickled erythrocyte. The dehydration of sickle erythrocytes increases intracellular HbS concentration and the prope
Externí odkaz:
https://doaj.org/article/2c9bacc87031420c84daa30f5d0874b2