Muscarinic receptors mediate motivation via preparatory neural activity in humans

Autor: John P Grogan, Matthias Raemaekers, Maaike MH van Swieten, Alexander L Green, Martin J Gillies, Sanjay G Manohar

Publikováno v: eLife, Vol 13 (2024)

Motivation depends on dopamine, but might be modulated by acetylcholine which influences dopamine release in the striatum, and amplifies motivation in animal studies. A corresponding effect in humans would be important clinically, since anticholinerg

Externí odkaz: https://doaj.org/article/1f7228fc7f3249e9952f28c5646eeedb

Effects of dopamine on reinforcement learning and consolidation in Parkinson’s disease

Autor: John P Grogan, Demitra Tsivos, Laura Smith, Brogan E Knight, Rafal Bogacz, Alan Whone, Elizabeth J Coulthard

Publikováno v: eLife, Vol 6 (2017)

Emerging evidence suggests that dopamine may modulate learning and memory with important implications for understanding the neurobiology of memory and future therapeutic targeting. An influential hypothesis posits that dopamine biases reinforcement l

Externí odkaz: https://doaj.org/article/1940e4a9601d48b697ae16cab628d21c

Dissociable effects of APOE-ε4 and β-amyloid pathology on visual working memory

Autor: William Coath, Susie M.D. Henley, Jonathan M. Schott, Sarah E Keuss, John P Grogan, Marcus Richards, Masud Husain, Jennifer M. Nicholas, Carole H. Sudre, Nick C. Fox, Ivanna M. Pavisic, Thomas D. Parker, Ian B. Malone, Sebastian J. Crutch, Kirsty Lu, David M. Cash, Christopher A. Lane, Sarah M Buchanan, Ashvini Keshavan, Sarah-Naomi James, Andrew Wong, Yoni Pertzov, Heidi Murray-Smith

Publikováno v: Nature Aging, 1(11), 1002-1009. Springer
Lu, K, Nicholas, J M, Pertzov, Y, Grogan, J, Husain, M, Pavisic, I M, James, S-N, Parker, T D, Lane, C A, Keshavan, A, Keuss, S E, Buchanan, S M, Murray-Smith, H, Cash, D M, Malone, I B, Sudre, C H, Coath, W, Wong, A, Henley, S M D, Fox, N C, Richards, M, Schott, J M & Crutch, S J 2021, ' Dissociable effects of APOE ε4 and β-amyloid pathology on visual working memory ', Nature Aging, vol. 1, no. 11, pp. 1002-1009 . https://doi.org/10.1038/s43587-021-00117-4

Although APOE e4 carriers are at substantially higher risk of developing Alzheimer’s disease than noncarriers1, controversial evidence suggests that APOE e4 might confer some advantages, explaining the survival of this gene (antagonistic pleiotropy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0034c023e0745c88de485b63381af33c
https://researchonline.lshtm.ac.uk/id/eprint/4667456/7/Lu_etal_2021_Dissociable-effects-of-apoe.pdf

Motivation improves working memory by two processes: Prioritisation and retrieval thresholds

Autor: John P. Grogan, Govind Randhawa, Minho Kim, Sanjay G. Manohar

Publikováno v: Cognitive psychology. 135

Motivation can improve performance when the potential rewards outweigh the cost of effort expended. In working memory (WM), people can prioritise rewarded items at the expense of unrewarded items, suggesting a fixed memory capacity. But can capacity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c4c374ea0eca4b58cbd1031dfeac0a
https://pubmed.ncbi.nlm.nih.gov/35364511

APOE‐ε4 carriers have superior recall on the ‘What was where?’ visual short‐term memory binding test at age 70, despite a detrimental effect of β‐amyloid

Autor: Thomas D. Parker, Nick C. Fox, Ashvini Keshavan, Jonathan M. Schott, Andrew Wong, Masud Husain, Marcus Richards, Sarah M Buchanan, Ian B. Malone, Jennifer M. Nicholas, Kirsty Lu, Yoni Pertzov, William Coath, David M. Cash, Sebastian J. Crutch, Christopher A. Lane, Sarah-Naomi James, Sarah E Keuss, John P Grogan, Susie M.D. Henley, Ivanna M. Pavisic, Heidi Murray-Smith

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4f7d5dd3b0e5447b3e7dd0764449775
https://doi.org/10.1002/alz.041090