Zobrazeno 1 - 10
of 121
pro vyhledávání: '"John P Dowling"'
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174011 (2017)
Daxx was originally isolated as a Fas-binding protein. However, the in vivo function of Daxx in Fas-induced apoptosis has remained enigmatic. Fas plays an important role in homeostasis in the immune system. Fas gene mutations lead to autoimmune-lymph
Externí odkaz:
https://doaj.org/article/de4c17302c704664a0c7eec47e51a997
Publikováno v:
Frontiers in Ophthalmology, Vol 4 (2024)
IntroductionMacular Telangiectasia type 2 (MacTel), is an uncommon form of late-onset, slowly-progressive macular degeneration. Associated with regional Müller glial cell loss in the retina and the amino acid serine synthesized by Müller cells, the
Externí odkaz:
https://doaj.org/article/e1774c291eeb42c183cf54483b710e31
Autor:
John P. Dowling, Pavel A. Nikitin, Fang Shen, Halley Shukla, James P. Finn, Nirja Patel, Cezary Swider, Jamie L. Bingaman-Steele, Chris Nicolescu, Eden L Sikorski, Evan J. Greenawalt, Michael J. Morin, Matthew K. Robinson, Karen Lundgren, Benjamin C. Harman
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTImmune checkpoint inhibitors that overcome T cell suppressive mechanisms in tumors have revolutionized the treatment of cancer but are only efficacious in a small subset of patients. Targeting suppressive mechanisms acting on innate immune ce
Externí odkaz:
https://doaj.org/article/687ffc074dce4fcdb4a25e4af9665e76
Autor:
Jillian M. DiMuzio, Baron C. Heimbach, Raymond J. Howanski, John P. Dowling, Nirja B. Patel, Noeleya Henriquez, Chris Nicolescu, Mitchell Nath, Antonio Polley, Jamie L. Bingaman, Todd Smith, Benjamin C. Harman, Matthew K. Robinson, Michael J. Morin, Pavel A. Nikitin
Publikováno v:
Vaccine: X, Vol 8, Iss , Pp 100098- (2021)
Patients who recover from SARS-CoV-2 infections produce antibodies and antigen-specific T cells against multiple viral proteins. Here, an unbiased interrogation of the anti-viral memory B cell repertoire of convalescent patients has been performed by
Externí odkaz:
https://doaj.org/article/3838a23d47594e7298ad698becdb3b0c
Autor:
Charles L Zucker, John E Dowling
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 1, Pp 113-114 (2022)
Externí odkaz:
https://doaj.org/article/dd8835895ad24800a915ae0293241f61
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Programmed cell death regulates early development but how various factors (for example, TRADD, FADD and RIPKs) regulate this is unclear. Here, the authors show that a single allele of Tradd is essential for survival, when both Ripk3 and Ripk1 are kno
Externí odkaz:
https://doaj.org/article/87a04eb49a6d4286879173b72990596b
Autor:
James W. van der Wolde, Victor G. Puelles, Luise A. Cullen-McEwen, James A. Armitage, Jan Czogalla, Fabian Haas, Kotaro Haruhara, Leon Tribolet, Yusuke Okabayashi, John F. Bertram, John P. Dowling, Wendy E. Hoy, M. Jane Black, Robert De Matteo, Michael G. Bertram
Publikováno v:
American Journal of Physiology-Renal Physiology. 321:F322-F334
The present study shows, for the first time, that low birth weight as a result of maternal nutrition is associated with low podocyte endowment. However, a mild podocyte deficit at birth did not result in glomerular pathology in adulthood. In contrast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0220604b68b016cba891a1d211f430d0
https://doi.org/10.1152/ajprenal.00029.2021
https://doi.org/10.1152/ajprenal.00029.2021
Autor:
Pavel A. Nikitin, Jillian M. DiMuzio, John P. Dowling, Nirja B. Patel, Jamie L. Bingaman-Steele, Baron C. Heimbach, Noeleya Henriquez, Chris Nicolescu, Antonio Polley, Eden L. Sikorski, Raymond J. Howanski, Mitchell Nath, Halley Shukla, Suzanne M. Scheaffer, James P. Finn, Li-Fang Liang, Todd Smith, Nadia Storm, Lindsay G. A. McKay, Rebecca I. Johnson, Lauren E. Malsick, Anna N. Honko, Anthony Griffiths, Michael S. Diamond, Purnanand Sarma, Dennis H. Geising, Michael J. Morin, Matthew K. Robinson
Publikováno v:
Science Immunology. 7
Monoclonal antibodies are an efficacious therapy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, rapid viral mutagenesis led to escape from most of these therapies, outlining the need for an antibody cocktail with a bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba9c0fe6a471aff9ca68ce2d284df07
https://doi.org/10.1126/sciimmunol.abl9943
https://doi.org/10.1126/sciimmunol.abl9943
Autor:
Pavel A. Nikitin, Jillian M. DiMuzio, John P. Dowling, Nirja B. Patel, Jamie L. Bingaman-Steele, Baron C. Heimbach, Noeleya Henriquez, Chris Nicolescu, Antonio Polley, Eden L. Sikorski, Raymond J. Howanski, Mitchell Nath, Halley Shukla, Suzanne M. Scheaffer, James P. Finn, Li-Fang Liang, Todd Smith, Nadia Storm, Lindsay G. A. McKay, Rebecca I. Johnson, Lauren E. Malsick, Anna N. Honko, Anthony Griffiths, Michael S. Diamond, Purnanand Sarma, Dennis H. Geising, Michael J. Morin, Matthew K. Robinson
Using an unbiased interrogation of the anti-viral memory B cell repertoire of convalescent COVID-19 patients, we identified three human antibodies that when combined demonstrated both robust viral suppressive properties against all tested SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fca46853486ce71107671127e851ce01
https://doi.org/10.1101/2021.10.18.464900
https://doi.org/10.1101/2021.10.18.464900
Autor:
John P Dowling, Pavel A Nikitin, Fang Shen, James P Finn, Nirja Patel, Cezary Swider, Jamie Steele, Halley Shukla, Matthew K Robinson, Karen Lundgren, Benjamin C Harman
Publikováno v:
Molecular Cancer Therapeutics. 20:LBA022-LBA022
Immune checkpoint inhibitors that overcome T cell suppressive mechanisms in tumors have revolutionized the treatment of cancer. However, therapies targeting innate immune cell subsets that orchestrate adaptive immune responses could significantly imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50521b0d8fffba8fe695268fd3568269
https://doi.org/10.1158/1535-7163.targ-21-lba022
https://doi.org/10.1158/1535-7163.targ-21-lba022