Zobrazeno 1 - 10
of 369
pro vyhledávání: '"John P, Lydon"'
Autor:
Sangappa B. Chadchan, Pooja Popli, Zian Liao, Eryk Andreas, Michelle Dias, Tianyuan Wang, Stephanie J. Gunderson, Patricia T. Jimenez, Denise G. Lanza, Rainer B. Lanz, Charles E. Foulds, Diana Monsivais, Francesco J. DeMayo, Hari Krishna Yalamanchili, Emily S. Jungheim, Jason D. Heaney, John P. Lydon, Kelle H. Moley, Bert W. O’Malley, Ramakrishna Kommagani
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are governed by their cognate receptor’s transcriptional output. However, the feed-forward mechanisms that shape cell-type-specific transcriptional fulcrums f
Externí odkaz:
https://doaj.org/article/116dab8ea7be413e937452d604e585f3
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Estrogen and progesterone, acting through their cognate receptors the estrogen receptor α (ERα) and the progesterone receptor (PR) respectively, regulate uterine biology. Using rapid immunoprecipitation and mass spectrometry (RIME) and co-
Externí odkaz:
https://doaj.org/article/f1d18940f90c41139b4b1583edd5eab3
Autor:
Seung Chel Yang, Mira Park, Kwon-Ho Hong, Hyeonwoo La, Chanhyeok Park, Peike Wang, Gaizhen Li, Qionghua Chen, Youngsok Choi, Francesco J. DeMayo, John P. Lydon, David G. Skalnik, Hyunjung J. Lim, Seok-Ho Hong, So Hee Park, Yeon Sun Kim, Hye-Ryun Kim, Haengseok Song
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Progesterone (P4) is required for the preparation of the endometrium for a successful pregnancy. P4 resistance is a leading cause of the pathogenesis of endometrial disorders like endometriosis, often leading to infertility; however, the und
Externí odkaz:
https://doaj.org/article/6444b23feea846438ea6b8cd5143100b
Autor:
Matthew Brown, Alicia Leon, Katarzyna Kedzierska, Charlotte Moore, Hayley L Belnoue‐Davis, Susanne Flach, John P Lydon, Francesco J DeMayo, Annabelle Lewis, Tjalling Bosse, Ian Tomlinson, David N Church
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 10, Pp n/a-n/a (2023)
Abstract High‐risk endometrial cancer has poor prognosis and is increasing in incidence. However, understanding of the molecular mechanisms which drive this disease is limited. We used genetically engineered mouse models (GEMM) to determine the fun
Externí odkaz:
https://doaj.org/article/5c8f6de2c4ae45eeb10187d03d135ae1
Autor:
Yeongseok Oh, Elvis Quiroz, Tianyuan Wang, Yassmin Medina-Laver, Skylar Montague Redecke, Francisco Dominguez, John P. Lydon, Francesco J. DeMayo, San-Pin Wu
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Endometrial function is dependent on a tight crosstalk between the epithelial and stromal cells of the endometrium. This communication is critical to ensure a fertile uterus and relies on progesterone and estrogen signaling to prepare a receptive ute
Externí odkaz:
https://doaj.org/article/0fa7791da6b044fb83b2d6338c0b99db
Autor:
Vineet K. Maurya, Maria M. Szwarc, David M. Lonard, William E. Gibbons, San-Pin Wu, Bert W. O’Malley, Francesco J. DeMayo, John P. Lydon
Publikováno v:
Frontiers in Reproductive Health, Vol 4 (2022)
Steroid receptor coactivator-3 (SRC-3; also known as NCOA3 or AIB1) is a member of the multifunctional p160/SRC family of coactivators, which also includes SRC-1 and SRC-2. Clinical and cell-based studies as well as investigations on mice have demons
Externí odkaz:
https://doaj.org/article/52e567cba52d40b295aa29f38efea790
Autor:
Xinzhe Yu, Ping Yi, Anil K. Panigrahi, Lance Edward V. Lumahan, John P. Lydon, David M. Lonard, Steven J. Lutdke, Zhao Wang, Bert W. O’Malley
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105321- (2022)
Summary: We report the quaternary structure of core transcriptional complex for the full-length human progesterone receptor-B (PR-B) homodimer with primary coactivator steroid receptor coactivator-2 (SRC-2) and the secondary coactivator p300/CREB-bin
Externí odkaz:
https://doaj.org/article/f16f61a190c24044a867d72e40402e48
Autor:
Soo Hyun Ahn, Sean L. Nguyen, Tae Hoon Kim, Jae-Wook Jeong, Ripla Arora, John P. Lydon, Margaret G. Petroff
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/d168b91766544c9a9579251da0893562
Autor:
Soo Hyun Ahn, Sean L. Nguyen, Tae Hoon Kim, Jae-Wook Jeong, Ripla Arora, John P. Lydon, Margaret G. Petroff
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Progesterone is a gonadal pro-gestational hormone that is absolutely necessary for the success of pregnancy. Most notable actions of progesterone are observed in the female reproductive organs, the uterus and the ovary. Acting through the nuclear pro
Externí odkaz:
https://doaj.org/article/5461c4abbba14e4c9ca7422ce24c3542
Autor:
Mubeen Goolam, Maria-Eleni Xypolita, Ita Costello, John P. Lydon, Francesco J. DeMayo, Elizabeth K. Bikoff, Elizabeth J. Robertson, Arne W. Mould
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The transcriptional repressor Blimp1/PRDM1 regulates cell fate decisions in the developing embryo and adult tissues. Here the authors show that conditional inactivation within maternal uterine tissues results in a defective primary decidual zone barr
Externí odkaz:
https://doaj.org/article/28a1cda4aae6436bbc84b29955a20204