Zobrazeno 1 - 10
of 100
pro vyhledávání: '"John P, Konhilas"'
Autor:
Rinku S. Skaria, Marissa A. Lopez‐Pier, Brij S. Kathuria, Christian J. Leber, Paul R. Langlais, Shravan G. Aras, Zain I. Khalpey, Pamela G. Hitscherich, Evangelia Chnari, Marc Long, Jared M. Churko, Raymond B. Runyan, John P. Konhilas
Publikováno v:
Physiological Reports, Vol 11, Iss 20, Pp n/a-n/a (2023)
Abstract Cardiac ischemic reperfusion injury (IRI) is paradoxically instigated by reestablishing blood‐flow to ischemic myocardium typically from a myocardial infarction (MI). Although revascularization following MI remains the standard of care, ef
Externí odkaz:
https://doaj.org/article/1914eda30e2946a1b3561fc74669f95e
Autor:
Christina Hoyer-Kimura, John P. Konhilas, Heidi M. Mansour, Robin Polt, Kristian P. Doyle, Dean Billheimer, Meredith Hay
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Background Decreased cerebral blood flow and systemic inflammation during heart failure (HF) increase the risk for vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer disease-related dementias (ADRD). We previous
Externí odkaz:
https://doaj.org/article/1f581aace31e48588560b1ea25934274
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 587 (2022)
Heart failure (HF) causes decreased brain perfusion in older adults, and increased brain and systemic inflammation increases the risk of cognitive impairment and Alzheimer’s disease (AD). Glycosylated Ang-(1-7) MasR agonists (PNA5) has shown improv
Externí odkaz:
https://doaj.org/article/c1ba98e2d7d141afb2d236efee83736a
Autor:
Preston R. Harris, Douglas A. Keen, Eleni Constantopoulos, Savanna N. Weninger, Eric Hines, Matthew P. Koppinger, Zain I. Khalpey, John P. Konhilas
Publikováno v:
Journal of the International Society of Sports Nutrition, Vol 16, Iss 1 (2019)
Background Exercise and heat trigger dehydration and an increase in extracellular fluid osmolality, leading to deficits in exercise performance and thermoregulation. Evidence from previous studies supports the potential for deep-ocean mineral water t
Externí odkaz:
https://doaj.org/article/88bcb6c9f92a4c20b7c1430f88f7a043
Autor:
Thomas G. Beach, Geidy E. Serrano, Christina Hoyer-Kimura, John P. Konhilas, Lee Ryan, Henrik Zetterberg, Kaj Blennow, Matthew J. Huentelman, Sairam Parthasarathy, Meredith Hay, Eric M. Reiman
Publikováno v:
Cardiology and cardiovascular medicine
In critically ill COVID-19 patients, the risk of long-term neurological consequences is just beginning to be appreciated. While recent studies have identified that there is an increase in structural injury to the nervous system in critically ill COVI
Autor:
Xiaoyun Wang, G.L. Kinney, Maor Sauler, Duo Zhang, Michael Tomchaney, Tianshi David Wu, Bartolome R. Celli, Jaroslaw W. Zmijewski, Rick G. Schnellmann, Elizabeth Córdoba-Lanús, Kristan H. Cleveland, Jonathan Mayo, Craig P. Hersh, Judy Tram, John P. Konhilas, Paul R. Langlais, Ciro Casanova, Nadia N. Hansel, Yohannes Tesfaigzi, Samuel Packard, Joselyn Rojas-Quintero, Kevin Doubleday, Ashraf Fawzy, Meredith C. McCormack, Francesca Polverino, Irfan Rahman, Caroline A. Owen, Julie G. Ledford
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Am J Respir Crit Care Med
Am J Respir Crit Care Med
Rationale: Cigarette smoke (CS) inhalation triggers oxidative stress and inflammation, leading to accelerated lung aging, apoptosis, and emphysema, as well as systemic pathologies. Metformin is beneficial for protecting against aging-related diseases
Autor:
Natalie K. Barker, John M. Streicher, Attila Keresztes, Ryan Hecksel, Keith M. Olson, Marissa A. Lopez-Pier, Paul R. Langlais, Victor J. Hruby, John P. Konhilas, Paul L. Nguyen, Zekun Liu
Publikováno v:
Pain. 163:146-158
The opioid receptors are important regulators of pain, reward, and addiction. Limited evidence suggests the mu and delta opioid receptors form a heterodimer (MDOR), which may act as a negative feedback brake on opioid-induced analgesia. However, evid
Autor:
Jessica N Sanchez, Danielle K. Cannon, Hao Chen, Yulia Lipovka, Dennis P Pollow, Eleni Constantopoulos, Jessica A. Regan, John P. Konhilas, Rinku Skaria, Laurel A. McKee, Marissa A. Lopez-Pier, Heddwen L. Brooks
Publikováno v:
Am J Physiol Heart Circ Physiol
There is a sharp rise in cardiovascular disease (CVD) risk and progression with the onset of menopause. The 4-vinylcyclohexene diepoxide (VCD) model of menopause recapitulates the natural, physiological transition through perimenopause to menopause.
Autor:
Dalan R. Jensen, Leslie A. Knaub, John P. Konhilas, Leslie A. Leinwand, Paul S. MacLean, Robert H. Eckel
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 4, Pp 870-879 (2008)
LPL is an enzyme involved in the breakdown and uptake of lipoprotein triglycerides. In the present study, we examined how the transgenic (Tg) overexpression of human LPL in mouse skeletal muscle affected tolerance to cold temperatures, cold-induced t
Externí odkaz:
https://doaj.org/article/348bd9307a17413b98462235061ba1b0
Autor:
Meredith Hay, Robin Polt, Christina Hoyer-Kimura, John P. Konhilas, Heidi M. Mansour, Kristian P. Doyle, Dean Billheimer
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Decreased cerebral blood flow and systemic inflammation during heart failure (HF) increase the risk for vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer disease-related dementias (ADRD). We previously demons