Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)

Autor: Pamela Warner, Lucy Harriet Ravenscroft Whitaker, Richard Anthony Parker, Christopher John Weir, Anne Douglas, Christian Holm Hansen, Mayank Madhra, Stephen Gilbert Hillier, Philippa Tansy Kemp Saunders, John Peter Iredale, Scott Semple, Ov Daniel Slayden, Brian Robert Walker, Hilary Octavia Dawn Critchley

Publikováno v: EBioMedicine, Vol 69, Iss , Pp 103434- (2021)

Background: The symptom of heavy menstrual bleeding (HMB) diminishes quality-of-life for many mid-age women and imposes substantial societal burden. We investigated our hypothesis that HMB reflects impaired endometrial vasoconstriction due to endomet

Externí odkaz: https://doaj.org/article/248e215dd7644bcb8dcb87937967ee1f

CCR Translation on this Article from The Desmoplastic Reaction Surrounding Hepatic Colorectal Adenocarcinoma Metastases Aids Tumor Growth and Survival via αv Integrin Ligation

Autor: John P. Iredale, R. Christopher Benyon, John N. Primrose, Graham Packham, Qian Xu, Andrew Papa-Adams, Thomas A. Armstrong, Adrian Bateman, Timothy J. Kendall, John A. Conti

CCR Translation on this Article from The Desmoplastic Reaction Surrounding Hepatic Colorectal Adenocarcinoma Metastases Aids Tumor Growth and Survival via αv Integrin Ligation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8f2b2dc61bbd5b30087689dd4ef700
https://doi.org/10.1158/1078-0432.22439599

Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial.

Autor: Victoria K Snowdon, Neil J Lachlan, Anna M Hoy, Patrick W F Hadoke, Scott I Semple, Dilip Patel, Will Mungall, Timothy J Kendall, Adrian Thomson, Ross J Lennen, Maurits A Jansen, Carmel M Moran, Antonella Pellicoro, Prakash Ramachandran, Isaac Shaw, Rebecca L Aucott, Thomas Severin, Rajnish Saini, Judy Pak, Denise Yates, Neelesh Dongre, Jeremy S Duffield, David J Webb, John P Iredale, Peter C Hayes, Jonathan A Fallowfield

Publikováno v: PLoS Medicine, Vol 14, Iss 2, p e1002248 (2017)

BackgroundChronic liver scarring from any cause leads to cirrhosis, portal hypertension, and a progressive decline in renal blood flow and renal function. Extreme renal vasoconstriction characterizes hepatorenal syndrome, a functional and potentially

Externí odkaz: https://doaj.org/article/ab7417500a97421588c9af8b777a3c6d

Resolving the fibrotic niche of human liver cirrhosis at single cell level

Autor: Mirjana Efremova, Ross Dobie, Jonathan A. Fallowfield, Prakash Ramachandran, Stephen J. Wigmore, John P. Iredale, Ewen M Harrison, Kylie P. Matchett, John C. Marioni, David R. Mole, Christopher J. Weston, John A. Marwick, John R. Wilson-Kanamori, Roser Vento-Tormo, Philip N. Newsome, Sarah A. Teichmann, Neil C. Henderson, Neil O. Carragher, Richard S Taylor, Jordan R. Portman, Elena Dora, N T Luu, Frank Tacke, Chris P. Ponting, Jeffrey W. Pollard, Beth E. P. Henderson, Timothy J. Kendall, M Brice

Publikováno v: Nature
Ramachandran, P, Dobie, R, Wilson-Kanamori, J R, Dora, E F, Henderson, B E P, Luu, N T, Portman, J R, Matchett, K P, Brice, M, Marwick, J A, Taylor, R S, Efremova, M, Vento-Tormo, R, Carragher, N O, Kendall, T J, Fallowfield, J A, Harrison, E M, Mole, D J, Wigmore, S J, Newsome, P N, Weston, C J, Iredale, J P, Tacke, F, Pollard, J W, Ponting, C P, Marioni, J C, Teichmann, S A & Henderson, N C 2019, ' Resolving the fibrotic niche of human liver cirrhosis at single-cell level ', Nature, vol. 575, no. 7783, pp. 512–518 . https://doi.org/10.1038/s41586-019-1631-3

Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular mechanisms involved in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3362c457a2a6d54f3fadf6498190b2
http://europepmc.org/articles/PMC6876711

Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells

Autor: Marie Goepp, Konstantinos Gkikas, Konstantinos Gerasimidis, Luke C. Davies, Stephen M. Anderton, Jürgen Schwarze, Xue-Feng Li, Calum T. Robb, Valerie B. O'Donnell, Sarah E. M. Howie, Gwo-Tzer Ho, Victoria J. Tyrrell, Bin-Zhi Qian, Chengcan Yao, Alexander Adima, Hatti X. Yao, Shuh Narumiya, Richard M. Breyer, Adriano G. Rossi, John P. Iredale, Robert Andrews, Xiaozhong Zheng, Danielle J. Smyth, Amil Mair, Sonja Vermeren, Rick M. Maizels, Damian J. Mole, Richard A. O’Connor, You Zhou, Jolinda Pollock, Siobhan Crittenden, Mark J. Arends

Publikováno v: Crittenden, S, Goepp, M, Pollock, J, Robb, C, Smyth, D J, Zhou, Y, Andrews, R, Tyrrell, V, Gkikas, K, Adima, A, O'Connor, R A, Davies, L, Li, X-F, Yao, H X, Ho, G-T, Zheng, X, Mair, A, Vermeren, S, Qian, B-Z, Mole, D J, Gerasimidis, K, Schwarze, J, Breyer, R M, Arends, M J, O'donnell, V B, Iredale, J P, Anderton, S M, Narumiya, S, Maizels, R M, Rossi, A G, Howie, S E M & Yao, C 2021, ' Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells ', Science Advances . https://doi.org/10.1126/sciadv.abd7954
Science Advances

PGE2 inhibits Tregs and promotes intestinal inflammation through actions on mononuclear phagocytes and the gut microbiota.
The gut microbiota fundamentally regulates intestinal homeostasis and disease partially through mechanisms that involve mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fb977eba431e0466ac7c8a07e70cc7
https://orca.cardiff.ac.uk/id/eprint/138622/1/eabd7954.full.pdf