Zobrazeno 1 - 10
of 220
pro vyhledávání: '"John P, Higgins"'
Autor:
Daniel C. De Souza, Nicolas Hebert, Erica B. Esrick, M. Felicia Ciuculescu, Natasha M. Archer, Myriam Armant, Étienne Audureau, Christian Brendel, Giuseppe Di Caprio, Frédéric Galactéros, Donghui Liu, Amanda McCabe, Emily Morris, Ethan Schonbrun, Dillon Williams, David K. Wood, David A. Williams, Pablo Bartolucci, John M. Higgins
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract We previously reported initial clinical results of post-transcriptional gene silencing of BCL11A expression (NCT 03282656) reversing the fetal to adult hemoglobin switch. A goal of this approach is to increase fetal hemoglobin (HbF) expressi
Externí odkaz:
https://doaj.org/article/c27e3b0ea4ac4641bfd4b6b6b60347e0
Publikováno v:
IJU Case Reports, Vol 5, Iss 5, Pp 346-349 (2022)
Introduction Isolated seminal vesicle cysts not associated with Zinner syndrome is a rare disorder that can present initially with urinary obstructive symptoms or nonspecific groin pain. Case description We present the uncommon case of a dermoid cyst
Externí odkaz:
https://doaj.org/article/1eebe041d44c4e679d59a04efe7dfc35
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Inflammation is a protective response of the body. Here, authors show that healthy inflammation induces remarkably consistent changes in white cell and platelet populations, regardless of the underlying cause, including heart attack, infection and tr
Externí odkaz:
https://doaj.org/article/ad3c017b14d645ccb4d25d6cedfe0bd3
Autor:
John A. Higgins, Danielle Santiago Ramos, Stefania Gili, Cornelia Spetea, Scott Kanoski, Darren Ha, Alicia A. McDonough, Jang H. Youn
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
As the most abundant cation in archaeal, bacterial, and eukaryotic cells, potassium (K+) is an essential element for life. While much is known about the machinery of transcellular and paracellular K transport–channels, pumps, co-transporters, and t
Externí odkaz:
https://doaj.org/article/6b378dbf9368413786495828c89e6c06
Autor:
Kimberley K. Mayfield, Anton Eisenhauer, Danielle P. Santiago Ramos, John A. Higgins, Tristan J. Horner, Maureen Auro, Tomas Magna, Nils Moosdorf, Matthew A. Charette, Meagan Eagle Gonneea, Carolyn E. Brady, Nemanja Komar, Bernhard Peucker-Ehrenbrink, Adina Paytan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Groundwater discharge is a mechanism that transports chemicals from inland systems to the ocean, but it has been considered of secondary influence compared to rivers. Here the authors assess the global significance of groundwater discharge, finding t
Externí odkaz:
https://doaj.org/article/18dda10878ea4e5f8d911ae2975143cd
Autor:
Harsh Singh, B.A., Inis Isak, B.S., William M. Cregar, M.D., John D. Higgins, M.D., Amar S. Vadhera, B.S., Allison K. Perry, B.S., Gregory P. Nicholson, M.D., Brian J. Cole, M.D., M.B.A., Nikhil N. Verma, M.D.
Publikováno v:
Arthroscopy, Sports Medicine, and Rehabilitation, Vol 3, Iss 6, Pp e1853-e1856 (2021)
Purpose: To establish an infection rate following primary arthroscopic rotator cuff repair (ARCR) from a single institutional database and to ascertain whether there is a relationship between the use of preoperative corticosteroid injection (CSI) and
Externí odkaz:
https://doaj.org/article/77d49ad4d012493bbbc04cc6bc3eff8f
Autor:
Athena C. Geisness, Melissa Azul, Dillon Williams, Hannah Szafraniec, Daniel C. De Souza, John M. Higgins, David K. Wood
Publikováno v:
Haematologica, Vol 107, Iss 6 (2021)
Sickle cell disease (SCD) is characterized by sickle hemoglobin (HbS) which polymerizes under deoxygenated conditions to form a stiff, sickled erythrocyte. The dehydration of sickle erythrocytes increases intracellular HbS concentration and the prope
Externí odkaz:
https://doaj.org/article/2c9bacc87031420c84daa30f5d0874b2
Autor:
John P. Higgins
Publikováno v:
The American Journal of Medicine. 136:355-359
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cf26d4f2b5e1678e64cdefcbf554f82
https://doi.org/10.1016/j.amjmed.2022.12.011
https://doi.org/10.1016/j.amjmed.2022.12.011
Publikováno v:
APL Bioengineering, Vol 3, Iss 4, Pp 046102-046102-9 (2019)
The pathology of sickle cell disease begins with the polymerization of intracellular hemoglobin under low oxygen tension, which leads to increased blood effective viscosity and vaso-occlusion. However, it has remained unclear how single-cell changes
Externí odkaz:
https://doaj.org/article/18179ae6b464457cb523a7cd57bce7f5
Publikováno v:
eLife, Vol 8 (2019)
Low blood count is a fundamental disease state and is often an early sign of illnesses including infection, cancer, and malnutrition, but our understanding of the homeostatic response to blood loss is limited, in part by coarse interpretation of bloo
Externí odkaz:
https://doaj.org/article/68e9fa8fa22a43d7b3c124463c14c9b4