Zobrazeno 1 - 10
of 595
pro vyhledávání: '"John P, Cooke"'
Autor:
Anna Laura Nelson, Chiara Mancino, Xueqin Gao, Joshua A. Choe, Laura Chubb, Katherine Williams, Molly Czachor, Ralph Marcucio, Francesca Taraballi, John P. Cooke, Johnny Huard, Chelsea Bahney, Nicole Ehrhart
Publikováno v:
Bioactive Materials, Vol 39, Iss , Pp 273-286 (2024)
Fractures continue to be a global economic burden as there are currently no osteoanabolic drugs approved to accelerate fracture healing. In this study, we aimed to develop an osteoanabolic therapy which activates the Wnt/β-catenin pathway, a molecul
Externí odkaz:
https://doaj.org/article/81cdecd9e4f146d3b17d47743564e65b
Autor:
Khanh M. Chau, Abishai Dominic, Eleanor L. Davis, Sivareddy Kotla, Estefani Turcios Berrios, Arsany Fahim, Ashwin Arunesh, Shengyu Li, Dongyu Zhao, Kaifu Chen, Alan R. Davis, Minh T. H. Nguyen, Yongxing Wang, Scott E. Evans, Guangyu Wang, John P. Cooke, Jun-ichi Abe, David P. Huston, Nhat-Tu Le
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2024)
BackgroundTraf2 and Nck-interacting kinase (TNIK) is known for its regulatory role in various processes within cancer cells. However, its role within endothelial cells (ECs) has remained relatively unexplored.MethodsLeveraging RNA-seq data and Ingenu
Externí odkaz:
https://doaj.org/article/8f5bf8c0dfad4de7bc1d2a5c762d2c0e
Autor:
Jie Lv, Shu Meng, Qilin Gu, Rongbin Zheng, Xinlei Gao, Jun-dae Kim, Min Chen, Bo Xia, Yihan Zuo, Sen Zhu, Dongyu Zhao, Yanqiang Li, Guangyu Wang, Xin Wang, Qingshu Meng, Qi Cao, John P. Cooke, Longhou Fang, Kaifu Chen, Lili Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract A comprehensive understanding of endothelial cell lineage specification will advance cardiovascular regenerative medicine. Recent studies found that unique epigenetic signatures preferentially regulate cell identity genes. We thus systematic
Externí odkaz:
https://doaj.org/article/14928c9950cd4eacb8762efe2e68b9ba
Autor:
Ashita Jain, Diego Casanova, Alejandra Valdivia Padilla, Angelica Paniagua Bojorges, Sivareddy Kotla, Kyung Ae Ko, Venkata S. K. Samanthapudi, Khanh Chau, Minh T. H. Nguyen, Jake Wen, Selina L. Hernandez Gonzalez, Shaefali P. Rodgers, Elizabeth A. Olmsted-Davis, Dale J. Hamilton, Cielito Reyes-Gibby, Sai-Ching J. Yeung, John P. Cooke, Joerg Herrmann, Eduardo N. Chini, Xiaolei Xu, Syed Wamique Yusuf, Momoko Yoshimoto, Philip L. Lorenzi, Brain Hobbs, Sunil Krishnan, Efstratios Koutroumpakis, Nicolas L. Palaskas, Guangyu Wang, Anita Deswal, Steven H. Lin, Jun-ichi Abe, Nhat-Tu Le
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality, especially among the aging population. The “response-to-injury” model proposed by Dr. Russell Ross in 1999 emphasizes inflammation as a critical factor in atherosclerosis
Externí odkaz:
https://doaj.org/article/f88dfe27f863446b91fe021a59c753ff
Autor:
Minh T. H. Nguyen, Masaki Imanishi, Shengyu Li, Khanh Chau, Priyanka Banerjee, Loka reddy Velatooru, Kyung Ae Ko, Venkata S. K. Samanthapudi, Young J. Gi, Ling-Ling Lee, Rei J. Abe, Elena McBeath, Anita Deswal, Steven H. Lin, Nicolas L. Palaskas, Robert Dantzer, Keigi Fujiwara, Mae K. Borchrdt, Estefani Berrios Turcios, Elizabeth A. Olmsted-Davis, Sivareddy Kotla, John P. Cooke, Guangyu Wang, Jun-ichi Abe, Nhat-Tu Le
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundThe deSUMOylase sentrin-specific isopeptidase 2 (SENP2) plays a crucial role in atheroprotection. However, the phosphorylation of SENP2 at T368 under disturbed flow (D-flow) conditions hinders its nuclear function and promotes endothelial c
Externí odkaz:
https://doaj.org/article/b6f1e08e085d437dabddc7e3719fecfb
Autor:
Priyanka Banerjee, Julia Enterría Rosales, Khanh Chau, Minh T. H. Nguyen, Sivareddy Kotla, Steven H. Lin, Anita Deswal, Robert Dantzer, Elizabeth A. Olmsted-Davis, Hung Nguyen, Guangyu Wang, John P. Cooke, Jun-ichi Abe, Nhat-Tu Le
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Cancer survivors undergone treatment face an increased risk of developing atherosclerotic cardiovascular disease (CVD), yet the underlying mechanisms remain elusive. Recent studies have revealed that chemotherapy can drive senescent cancer cells to a
Externí odkaz:
https://doaj.org/article/cec1f71c867b45be903698f6ffeae7b5
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Electrical stimulation, the application of an electric field to cells and tissues grown in culture to accelerate growth and tight junction formation among endothelial cells, could be impactful in cardiovascular tissue engineering, allot
Externí odkaz:
https://doaj.org/article/b7ab0624e7064e1191e08c638bd729c9
Autor:
John P. Cooke, Li Lai
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Tissue repair requires the orchestration of multiple processes involving a multiplicity of cellular effectors, signaling pathways, and cell-cell communication. The regeneration of the vasculature is a critical process for tissue repair and involves a
Externí odkaz:
https://doaj.org/article/81c2db06451041a29d4ff2a82589f3a8
Autor:
Xiaofang Tang, Yingjun Luo, Dongqiang Yuan, Riccardo Calandrelli, Naseeb Kaur Malhi, Kiran Sriram, Yifei Miao, Chih-Hong Lou, Walter Tsark, Alonso Tapia, Aleysha T. Chen, Guangyu Zhang, Daniel Roeth, Markus Kalkum, Zhao V. Wang, Shu Chien, Rama Natarajan, John P. Cooke, Sheng Zhong, Zhen Bouman Chen
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Impaired angiogenesis in diabetes is a key process contributing to ischemic diseases such as peripheral arterial disease. Epigenetic mechanisms, including those mediated by long noncoding RNAs (lncRNAs), are crucial links connecting diabetes and the
Externí odkaz:
https://doaj.org/article/17124107ddb64a87bca90326d3684d5f
Autor:
Gianfranco Matrone, Sung Yun Jung, Jong Min Choi, Antrix Jain, Hon-Chiu Eastwood Leung, Kimal Rajapakshe, Cristian Coarfa, Julie Rodor, Martin A. Denvir, Andrew H. Baker, John P. Cooke
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The role of the post-translational modifications in tissue regeneration is still not clearly understood. Here, the authors show that many nuclear proteins change S-nitrosylation state in the regenerating zebrafish tailfin, highlighting the importance
Externí odkaz:
https://doaj.org/article/adfe028e44264c2b8db2eceb6959bc23